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| 1 | Assessment of drug-induced hepatotoxicity in clinical practice: A challenge for gastroenterologists显示文摘Currently, pharmaceutical preparations are serious contributors to liver disease; hepatotoxicity ranking as the most frequent cause for acute liver failure and post-commercialization regulatory decisions. The diagnosis of hepatotoxicity remains a difficult task because of the lack of reliable markers for use in general clinical practice. To incriminate any given drug in an episode of liver dysfunction is a step-by-step process that requires a high degree of suspicion, compatible chronology, awareness of the drug’s hepatotoxic potential, the exclusion of alternative causes of liver damage and the ability to detect the presence of subtle data that favors a toxic etiology. This process is time-consuming and the final result is frequently inaccurate. Diagnostic algorithms may add consistency to the diagnostic process by translating the suspicion into a quantitative score. Such scales are useful since they provide a framework that emphasizes the features that merit attention in cases of suspected hepatic adverse reaction as well. Current efforts in collecting bona fide cases of drug-induced hepatotoxicity will make refinements of existing scales feasible. It is now relatively easy to accommodate relevant data within the scoring system and to delete low-impact items. Efforts should also be directed toward the development of an abridged instrument for use in evaluating suspected drug-induced hepatotoxicity at the very beginning of the diagnosis and treatment process when clinical decisions need to be made. The instrument chosen would enable a confident diagnosis to be made on admission of the patient and treatment to be fine-tuned as further information is collected. | Raúl J Andrade Mercedes Robles Alejandra Fernández-Castaer Susana López-Ortega M Carmen López-Vega M Isabel Lucena | 2007 | World Journal of Gastroenterology2007，13，3： | 18 |
| 2 | drug-induced autoimmune liver disease:a diagnostic dilemma of an increasingly reported disease显示文摘The aetiology of autoimmune hepatitis(AIH) is uncer-tain but the disease can be triggered in susceptible patients by external factors such as viruses or drugs.AIH usually develops in individuals with a genetic back-ground mainly consisting of some risk alleles of the major histocompatibility complex(HLA).Many drugs have been linked to AIH phenotypes,which sometimes persist after drug discontinuation,suggesting that they awaken latent autoimmunity.At least three clini-cal scenarios have been proposed that refers to drug- induced autoimmune liver disease(DIAILD):AIH with drug-induced liver injury(DILI); drug induced-AIH(DI-AIH); and immune mediated DILI(IM-DILI).In addi-tion,there are instances showing mixed features of DI-AIH and IM-DILI,as well as DILI cases with positive autoantibodies.Histologically distinguishing DILI from AIH remains a challenge.Even more challenging is the differentiation of AIH from DI-AIH mainly relying in histological features; however,a detailed standard-ised histologic evaluation of large cohorts of AIH and DI-AIH patients would probably render more subtle features that could be of help in the differential diag-nosis between both entities.Growing information on the relationship of drugs and AIH is being available,being drugs like statins and biologic agents more fre-quently involved in cases of DIAILD.In addition,there is some evidence on the fact that patients diagnosed with DIAILD may have had a previous episode of hepa-totoxicity.Further collaborative studies in DIAILD will strengthen the knowledge and understanding of this intriguing and complex disorder which might represent different phenotypes across the spectrum of | Agustin Castiella Eva Zapata M Isabel Lucena Raúl J Andrade | 2014 | World Journal of Hepatology2014，6，4： | 13 |
| 3 | Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy: Is there still a role for these drugs?显示文摘四乙秋兰姆化二硫和钙 carbimide 是二白酒威慑然而,广泛地在那里在酒精中毒治疗使用的狂言存在对他们的安全的大担心。hepatotoxicity 上的报告主要与四乙秋兰姆化二硫治疗有关,被出版了。钙 carbimide 的肝毒素的潜力是很好描绘的更少。这里,我们描述与被提交到 hepatotoxicity 的一张注册表并且当规定这些混合物时,指出我们面对的限制的这个治疗学的组有关的肝损坏的四个案例。对在白酒依赖的管理的这些混合物的角色的重估清楚地被需要。 | Carmen Verge M Isabel Lucena Enrique López-Torres M José Puche-García Enrique Fraga Manuel Romero-Gomez Raúl J Andrade | 2006 | World Journal of Gastroenterology2006，12，31： | 2 |
| 4 | Heavy metal sorption and desorption capacity of soils containing endogenous contaminants 显示文摘 | COVELO E F VEGA F A ANDRADE M L | 2007 | Journal of Hazardous Materials2007，143，： | 1 |
| 5 | Effects of tillage method and crop rotation on the population sizes and diversity of bradyrhizobia nodulating soybean显示文摘 | FERREIRA M C ANDRADE D S CHUEIRE L M O | 2000 | Soil Biology Biochemistry2000，32，： | 1 |
| 6 | Successful preservation of fertility subsequent to a complete pathologic response of a squamous cell carcinama of the uterine cervix treated with primary systemic chemotherapy显示文摘 | Andrade J M Marana H R Mangieri L F | 2000 | Gynecol Oncol2000，77，1： | 1 |
| 7 | Catalytic Effect of Magnetic Nanoparticles Over the H202 Decomposition Reaction显示文摘 | Andrade A L Souza D M Pereira M C | 2009 | J NanosciNanotechnol2009，9，5： | 1 |
| 8 | Competitive sorption and desorption of heavy metals by individual soil components显示文摘 | Covelo E F Vega F A Andrade M L | 2007 | Journal of Hazardous Materials2007，140，1： | 1 |
| 9 | Synthesis of aNiFe204 catalyst for the preferential oxidation of carbon monoxide (PROX)显示文摘 | SANTOS P T A COSTA A C F M KIMINAMI R H G A ANDRADE H M C LIRA H L GAMA L | 2009 | Journal of Alloy and Compounds2009，483，12： | 1 |
| 10 | Drug-induced liver injury: Interactions between drug properties and host factors显示文摘 | Minjun Chen Ayako Suzuki Jürgen Borlak Raúl J. Andrade M Isabel Lucena | 2015 | Journal of Hepatology2015，，2： | 1 |
| 11 | Competitive sorption and desorption of heavy metals by individual soil components 显示文摘 | Covelo E F Vega F A Andrade M L | 2007 | Journal of Hazardous Materials2007，140，： | 1 |
| 12 | Chronic inter- mittent hypoxia increases sympathetic control of blood pressure: role of neuronal activity in the hypothalamic paraventricular nucle- us显示文摘 | Sharpe A L Calderon A S Andrade M A | 2013 | Am J Physiol Heart Circ Physiol2013，305，12： | 1 |
| 13 | Light microenvironments ? growth and photosynthesisfor pitahaya ( Hylocereus undatus ) in an agrosystemof Yucatan, Mexico 显示文摘 | ANDRADE J L RENGIFO E’RICALDE M F | 2006 | Agrociencia ( Montecillo)?20062006，，： | 1 |
| 14 | Friedel-Crafts acylaiton of anisole with acetic anhydride over silica-supported hetempolyphostungstic acid (HPW/SiO2 )显示文摘 | CARDOSO L A M ALVES W It GONZAGA A R E AGUIAR L M G ANDRADE H M C | 2004 | J Mol Catal A2004，209，12： | 1 |
| 15 | Varietal identification of coffee seeds by RAPD technique显示文摘 | Croehemore M L Nunes L M Andrade G A | 2004 | Brazilian Archives of Biology and Technology2004，47，1： | 1 |
| 16 | Tree vegetation and waste amendments to improve the physical condition of copper mine soils显示文摘 | ASENSIO V VEGA F A ANDRADE M L COVELO E F | 2013 | Chemosphere2013，90，2： | 1 |
| 17 | Competitive sorption and desorption of heavy metals by individual soil components显示文摘 | Covelo E F Vega F A Andrade M L | 2007 | Journal of Hazardous Materials2007，140，： | 1 |
| 18 | Effect of molybdenum, niobium,and vanadium on static recovery and recrystallization and on solute strengtheningand microalloyed steels 显示文摘 | Andrade H L Akben M G Jonas J J | 1983 | Metallurgical Transactions A1983，14，： | 1 |
| 19 | Zn adsorption by different fractions of Galician soils显示文摘 | COVELO E F ALVAREZ N ANDRADE M L | 2004 | J Colloid Interface Sci2004，280，： | 1 |
| 20 | Potential errors in measurement of nonuniform sap flow using heat dissipation probes显示文摘 | CLEARWATER M J MEINZER F C ANDRADE J L | 1999 | Tree Physiology1999，19，10： | 1 |
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