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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Levels of Expression of P-Selectin, E-Selectin, and Intercellular Adhesion Molecule-1 in Coronary Atherectomy Specimens from Patients With Stable and Unstable Angina Pectoris显示文摘 | Alan N Tenaglia MD Andrew J Buda MD Robert G Wilkins MD Michael K Barron MD Paul R Jeffords BS Khoa Vo BS Maureen O Jordan BS Barry A Kusnick MD David J Lefer PhD | 1997 | The American Journal of Cardiology1997，，6： | 1 |
| 3 | The CRE-binding protein dCREB-A is required for Drosophila embryonic devel- opment显示文摘 | Rose R E Gallaher N M Andrew D J | 1997 | Genetics1997，146，2： | 1 |
| 4 | Crop production during conversion from conventional to low- input methods显示文摘 | Liebhardt W C Andrews R W Culik M N | 1989 | Agronomy1989，81，： | 1 |
| 5 | Enzymatic Hydrolysis of Flavonoids and Pectic Oligosaccha- rides from Bergamot (Citrus bergamia Risso) Peel 显示文摘 | GIUSEPPINA M RICHARD N B ANDREW R K | 2006 | J Agric Food Chem2006，，54： | 1 |
| 6 | Diversity and assemblage structure of phytophagous Hemiptera along a latitudinal gradient: predicting the potential impacts of climate change 显示文摘 | ANDREW N R HUGHES L | 2005 | Global Ecology and Biogeography2005，14，3： | 1 |
| 7 | Nanoscale hydrodynamics : Enhanced flow in carbon nanotubes 显示文摘 | Majumder M Chopra N Andrews R | 2005 | Nature2005，438，： | 1 |
| 8 | The genomic and epidemiologica dynamics of human influenza A virus显示文摘 | Andrew R Oliver G P Martha I N etal | 2008 | Nature2008，453，： | 1 |
| 9 | A philosophy of environmental impact assessment显示文摘 | ANDREWS R N L | 1973 | Journal of Soil and Water Conservation1973，，28： | 1 |
| 10 | Acoustic and Ion Sensing of Lean Blowout in an Aircraft Combustor Simulator显示文摘 | SURAJ N RAJESH R ANDREW J M | 2005 | American Institute of Aeronautics and Astronautics2005，32，5： | 1 |
| 11 | Nanoscale hydrodynamics: Enhanced flow in carbon nanotubes显示文摘 | Majumder M Chopra N Andrews R | 2005 | Nature2005，438，7064： | 1 |
| 12 | The seroepidemiology of herpes simpex virus type 1in Europe显示文摘 | Pebody RG Andrews N Brown D Gopal R De Melker H Francois G | 2004 | Sex Transm Infect2004，80，3： | 1 |
| 13 | Effect of gabapentin-like compounds on development and maintenance of morphine-induced conditioned place preference显示文摘 | Andrews N Loomis S Blake R | 2001 | Psychopharmacology2001，157，4： | 1 |
| 14 | Serological basis for use of meningococcal semgroup C conjugate vaccines in the United Kingdom: reevaluation of correlates of protection 显示文摘 | Borrow R Andrews N Goldblatt D | 2001 | Infect Im- mun2001，69，3： | 1 |
| 15 | Fluorescent labels, confocal microscopy, and quantitative image analysis in study of fungal biology显示文摘 | Spear R N Cullen D Andrews J H | 1999 | Methods Enzymol1999，307，： | 1 |
| 16 | Chronic restraint stress during early Theiler's virus infection exacerbates the subsequent demyelinating disease in SJL mice 显示文摘 | Amy N S Andrew J S Colin R Y | 2004 | J Neuroimmunol2004，155，： | 1 |
| 17 | Relationship between CO2 assimilations, photosynthetic electron transport, and active O2 metabolism in leaves of maize in the field during periods of low temperature 显示文摘 | FRYER M J ANDREWS J R OXBOROUGH K Blowers D A Baker N R | 1998 | Plant Physiol1998，116，： | 1 |
| 18 | Storage effects on anthocyanins, phenolics and antioxidant activity of thermally processed conventional and organic blueberries 显示文摘 | Syamaladevi R M Andrews P K Davies N M | 2012 | Journal of the Science of Food and Agriculture2012，92，4： | 1 |
| 19 | Breslow, Russell Ross ApoE-Deficient Mice develop lesions of all phases of atherosclerosis throughout the arterial tree 显示文摘 | YUTAKA N ANDREW S P ELAINE W R | 1994 | Arterioscler And thrombosis1994，14，1： | 1 |
| 20 | The impacts of temperature forecast un- certainty on Bayesian load forecasting显示文摘 | ANDREW P SOUGLAS ARTHUR M BREIPOHL FRED N LEE ADAPA R | 1998 | IEEE Trans On Power Systems1998，13，4： | 1 |
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