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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Ovarian autoimmune disease: clinical concepts and anima models显示文摘卵巢不是一个 immunologically 给予优惠的机关,但是在为卵巢特定的抗原的 tolerogenic 机制的一个故障在生育力上有灾难性的后果在里面女人,和这在自体免疫的疾病的鼠科的模型被复制。孤立的卵巢的自体免疫的疾病在女人是稀罕的,由于疾病和无能到的严厉可能播送越过代授与卵巢的疾病的基因信息。尽管如此,自体免疫的卵巢炎经常与另外的自体免疫的疾病联合被观察,特别地自体免疫的肾的疾病,并且在社会和单个健康上拿使用费。在老鼠的研究揭示了保护卵巢免受自体免疫的攻击的伤害的至少二机制。这些机制为自体免疫的管理者(亚耳河) 由导出胸腺的规章的 T 房间,以及一个角色包括 autoreactive T 房间的控制,在髓的 thymic 导致限制织物的抗原的表示的一个 transcriptional 管理者上皮的房间在 T 房间的开发期间。尽管后者机制不完全地被定义,也的失败导致自体免疫调停指向和卵巢的滤泡的弄空,这很好被建立。在这评论,我们将探讨自体免疫调停的临床的特征和后果在女人的卵巢的不孕,以及由动物揭示了的疾病的可能的机制当模特儿。 | Bryce D Warren William K Kinsey Lynda K McGinnis Lane K Christenson Susmita Jasti Anne M Stevens Brian K Petroff Margaret G Petroff | 2014 | Cellular & Molecular Immunology2014，11，6： | 3 |
| 3 | The impact of low cost airline operations toMalta显示文摘 | Anne G Nigel D | 2010 | Journal of Air Transport Management2010，，16： | 1 |
| 4 | Characterization of the AMPA2 Acti2 vated Receptors Present on Motoneurons显示文摘 | Ann G Sean D Donevan | 2007 | Journal of Neurochemistry2007，74，1： | 1 |
| 5 | Processing of a graded ceramic cutting tool in the Al2O3-ZrO2-Ti(C,N) system by electrophoretic deposition显示文摘 | VANMEENSEL K ANNE G JIANG D VLEUGELS J VAN DER BLEST O | 2005 | Functionally Graded Materials Viii2005，492，8： | 1 |
| 6 | Caspase- 2 induces apoptosis by releasing proapoptotic proteins from mitochondria显示文摘 | Yin G Srinivasa MS Anne D | 2002 | J Biol Chem2002，277，13： | 1 |
| 7 | Pathogenesis and Current Ap- proaches to Control of Varicella-Zoster Virus Infections 显示文摘 | Anne A G Michael D G | 2013 | Clin Microbiol Rev2013，26，4： | 1 |
| 8 | The response ot sod ero- sion and sediment export to land-use change in four areas of Europe : the importance of landscape pattern 显示文摘 | Martha M B Gerard G Anne V D | 2008 | Geomorphology2008，98，34： | 1 |
| 9 | A peroxidase gene promoter induced by phytopathogens and Methyl Jasmonate in transgenic plant显示文摘 | Mark D C Anne L R Anca G R | 1997 | Molecular Plant-Microbe Interactions1997，10，： | 1 |
| 10 | The impact of lowcost airline operations to Malta 显示文摘 | Anne G Nigel D | 2010 | Journal of Air Transport Management2010，，16： | 1 |
| 11 | Fractionation of wheat and wheat flour into starch and gluten: overview of the main processes and the factors involved显示文摘 | Van D B Anne G Hans V | 2005 | Journal of Cereal Science2005，41，3： | 1 |
| 12 | Synthesis ,stereochemistry and antitetrabenazne activity of bicycle analogues of 2-phenylmorpholines 显示文摘 | BOSWELL G E DAVID L M ANN O D | 1997 | J Heterocycl Chem1997，34，： | 1 |
| 13 | Cardiac aldosterone production and ventricular remodeling显示文摘 | Claude D Jean SS Anne G Hoff JT | 2000 | Kidney Int2000，57，： | 1 |
| 14 | A short synthesis of (±) -epiasarinin 显示文摘 | David J A Anne J D Patrick G S | 2002 | Organic Letters2002，7，4： | 1 |
| 15 | The allocation of in tan gile msoumes;the analytic hiermchy process and linemr program m ing显示文摘 | Saaty T L V ragas L G D ellm ann K | | 0，，37： | 1 |
| 16 | Vitreous hemorrhage in diabetic eyes previously treated with panretinal photoeoagulation显示文摘 | Kleinm ann G Hauser D Schechtm an E | 2008 | Int Ophthalmol2008，28，1： | 1 |
| 17 | Neissefial pofin (PorB) canses rapid calcium influx in target ceils and induces apoptesis by the activation of cysteine proteases显示文摘 | Anne M Dirk G Frank D | 1999 | EMBO J1999，18，2： | 1 |
| 18 | Enhanced cellular oxidant stress by the interaction of AGE with their receptors/binding proteins显示文摘 | Shi D Ann M Anderson G | 1994 | J Biol Chem1994，269，13： | 1 |
| 19 | A peroxidase gene promoter induced by phytopathogens and Methyl Jasmonate in transgenic plant 显示文摘 | Mark Curtis D Anne Rae L Anca Rusu G | 1997 | Molecular Plant Microbe interactions1997，，10： | 1 |
| 20 | Spatial structures of soil organic carbon in tropical forcst-A case study of southeastern Tanza-nia 显示文摘 | Joni R Annelies G Bruno D | 2009 | Catena2009，77，： | 1 |
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