|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cholangiocarcinoma, gone without the Wnt?显示文摘Cholangiocarcinoma(CCA) is a relatively rare malignancy of the intra- or extra-hepatic bile ducts that is classified according to its anatomical localization as intrahepatic, perihilar or distal. Overall, CCA has a dismal prognosis due to typical presentation at an advanced irresectable stage, lack of effective non-surgical treatments, and a high rate of disease recurrence. CCA frequently arises on a background of chronic liver inflammation and cholestasis. Chronic inflammation is accompanied by enhanced cell turnover with generation of additional inflammatory stimuli, and a microenvironment rich in pro-inflammatory mediators and proliferative factors that enable accumulation of mutations, transformation and expansion of mutated cells. A recent study by Boulter et al implicates the Wnt signaling cascade in cholangiocarcinogenesis. Wnt ligands Wnt7 B and Wnt10 A were found to be highly overexpressed in human CCA tissue. Wnt7 B protein was present throughout the tumor stroma, and often co-localized with a subset of CD68+ macrophages. To address in a direct manner whether Wnt signaling is engaged in development of CCA, Boulter et al explored the Wnt signaling pathway in an experimental model that recapitulates the multi-stage progression of human CCA.Wnt ligands found to be elevated in human CCA were also upregulated during the course of CCA development following thioacetamide treatment. Wnt10 a increased during the(pre-cancerous) regenerative phase, while Wnt7 b induction paralleled tumor growth. Along with upregulation of target genes, the findings demonstrate that the canonical Wnt pathway is progressively activated during cholangio-carcinogenesis. Macrophage depletion,eliminating a major source of Wnt7 b, prevented activation of the canonical Wnt cascade, and resulted in reduced number and volume of tumors in this model. Moreover,specific inhibitors of the canonical Wnt pathway(ICG-001 and C-59) caused reduction of tumor area and number,in xenograft and thioacetamide models of CCA. The aggregated findings show that experimental, and presumably human CCA, is a Wnt-driven tumor. Modulation of Wnt signaling, alone or in combination with surgicalor chemotherapy approaches, holds promise in the management of this fatal malignancy. | Anne T R Noll Thorsten Cramer Steven W M Olde Damink Frank G Schaap | 2016 | World Journal of Hepatology2016，8，26： | 3 |
| 2 | No Significant Association of 14 Candidate Genes With Schizophrenia in a Large European Ancestry Sample: Implications for Psychiatric Genetics显示文摘 | Sanders Alan R Duan Jubao Levinson Douglas F Shi Jianxin He Deli Hou Cuiping Burrell Gregory J Rice John P Nertney Deborah A Olincy Ann Rozic Pablo Vinogradov Sophia Buccola Nancy G Mowry Bryan J Freedman Robert Amin Farooq Black Donald W | 2008 | The American Journal of Psychiatry2008，，4： | 1 |
| 3 | Sc FOS a prebiotic for synbiotic associations:Recent studies in humans显示文摘 | Céline H Anne W Frédérique R | 2010 | Nutrafoods2010，9，1： | 1 |
| 4 | Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile显示文摘 | Anne W Schmidt Lorraine A Lebel Harry R Howard Stevin H Zorn | 2001 | European Journal of Pharmacology2001，，： | 1 |
| 5 | Atrial fibrillation after radiofrequency ablation of atrial flutter: preventive effect of angiotensin converting enzyme inhibitors, angiotensin Ⅱ receptor blockers, and diuretics显示文摘 | ANNE W WILLEMS R VAN DER MERWE N | 2004 | Heart2004，90，： | 1 |
| 6 | Characterization and comparison of hydrophilic and hydrophobic room temperature ionic liquids incorporating the imidazolium cation 显示文摘 | Jonathan G H Ann E V Matthew R W | 2001 | Green Chem2001，3，： | 1 |
| 7 | Matrix metalloproteinases and atrial remodeling in patients with mitral valve disease and atrial fibrillation显示文摘 | Anné W Willems R Roskams T | 2005 | Cardiovasc Res2005，67，4： | 1 |
| 8 | TGF - α - induced apoptosis is mediated by the adapter protein Daxx that facilitates NK activation 显示文摘 | Perlman R Schiem ann W P Brooks M W | 2001 | Nature Cell Biol2001，3，8： | 1 |
| 9 | Cross-language Informa- tion Retrieval 显示文摘 | Douglas W Oard Anne R Diekema | 1998 | Annual Review of Information Science and Technolo1998，，6： | 1 |
| 10 | ScFOS a prebiotic forsynbiotic associations: recent studies in humans 显示文摘 | CELINE H ANNE W FRfiD^RIQUE R | 2010 | 9(1): 23-272010，9，1： | 1 |
| 11 | Measuring optimism-pessimism from beliefs about future显示文摘 | Anne S R | 2000 | Personality and Individual Differ-ence2000，，28： | 1 |
| 12 | Measuring optimism-pessimism from beliefs about future显示文摘 | Leif W Anne S R | 2000 | Personality and Individual Difference2000，28，： | 1 |
| 13 | Phytoremediation of contaminated soils and groundwater: lessons from the field显示文摘 | Jaco V Rolf H Nele W Jana B Kristin A Ann R | 2009 | Environmental Science and Pollution Research2009，16，7： | 1 |
| 14 | Spectrocopic study of 1 : 1 copper( Ⅱ )complexes with Schiff base ligands derived from salicyaldehyde and L-histidine and its analogues显示文摘 | Machael R W Ann W | 1983 | Inorg Chem1983，22，： | 1 |
| 15 | Meta-Analysis of Calcium Supplementation for the Prevention of Postmenopausal Osteoporosis显示文摘 | Beverley S George W Ann C Nicole Z Vivian R Lauren G Zulma O Joan P Jonathan A Peter T Gordon G | 2002 | Endocrine Reviews2002，23，4： | 1 |
| 16 | Meta-Analysis of the Efficacy of Hormone Replacement Therapy in Treating and Preventing Osteoporosis in Postmenopausal Women显示文摘 | George W Peter T Beverley S Gordon G Joan P Nicole Z Vivian R David H Diane O Ann C | 2002 | Endocrine Reviews2002，23，4： | 1 |
| 17 | Atrial fibrillation after radiofrequency ablation of atrial flutter: preventive effect of angiotensin converting enzyme inhibitors,angiotensin Ⅱ receptor blockers, and diuretics显示文摘 | Anne W Willems R Van der Merwe N | 2004 | Heart2004，90，10： | 1 |
| 18 | DNA polymorphisms amplified by arbitrary primers are useful as genetic markers显示文摘 | JOHN G K W ANNE R K KENNETH J L | 1990 | Nucleic Acids Research1990，18，22： | 1 |
| 19 | Meta-Analysis of Raloxifene for the Prevention and Treatment of Postmenopausal Osteoporosis显示文摘 | Ann C Peter T Nicole Z Vivian R Bruce W Jonathan A George W Beverley S Gordon G | 2002 | Endocrine Reviews2002，23，4： | 1 |
| 20 | Terminal complement proteins C56-9 released basic fibroblast growth factor and platelet derived growth factor from endothelial cells显示文摘 | Laura R B Anne N W | 1994 | J Exper Med1994，179，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员