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| 1 | Treatment-related gastrointestinal toxicities and advanced colorectal or pancreatic cancer:A critical update显示文摘Gastrointestinal toxicities(GIT), including oral mucositis,nausea and vomiting, and diarrhea, are common side effects of chemotherapy and targeted agents in patients with advanced colorectal cancer and pancreatic cancer. Being often underreported, it is still difficult to precisely establish their burden in terms of both patient's quality of life and cancer care costs. Moreover, with the use of more intensive upfront combination regimens, the frequency of these toxicities is rapidly growing with a potential negative effect also on patient's outcome, as a result of dose reductions, delays or even discontinuation of active treatments. Thus, identifying patients at higher risk of developing GIT as well as an optimal management are paramount in order to improve patient's compliance and outcome. After the description of the main treatment-induced GIT, we discuss the current knowledge on the pathophysiology of these side effects and comment the scales commonly used to assess and grade them. We then provide a critical update on GIT incidence based on the results of key randomized trials conducted in patients with metastatic colorectal cancer and advanced pancreatic cancer. | Giuseppe Aprile Karim Rihawi Elisa De Carlo Stephen T Sonis | 2015 | World Journal of Gastroenterology2015，21，41： | 7 |
| 2 | 'Make or buy' decisions in the production of health care goods and services: new insights from institutional economics and organizational theory显示文摘 | Alexander S April H Phyllida T | 2000 | Bulletin of the World Health Organization2000，78，6： | 1 |
| 3 | 'Make or buy' decisions in the production of health care goods and services: new insights from institutional economics and organizational theory显示文摘 | Alexander S April H Phyllida T | 2000 | Bulletin of the World Health Organization2000，78，6： | 1 |
| 4 | Genomic organization and expression analyses of putrescine pathway genes in soybean显示文摘 | H E APRIL L W HALLNA T K | 2006 | Plant Physiolory and Biolchemistry2006，44，1： | 1 |
| 5 | Effect of practice on brain activity: An investigation in top-level rifle shooters 显示文摘 | Di R F Pitzalis S Aprile T | 2005 | Medicine and Science in Sports and Exercise2005，37，9： | 1 |
| 6 | Existence, multiplicity and profile of sign-changing clustered solutions of a semiclassical nonlinearSchr6dinger equation显示文摘 | D'Aprile T Pistoia A | 2009 | Ann Inst H Poincar''e Anal Non Lin''eaire2009，26，： | 1 |
| 7 | American college of rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee 显示文摘 | HOCHBERG M C ALTMAN R D APRIL K T | 2012 | Arthritis Care Res( Hoboken)2012，64，4： | 1 |
| 8 | Existence of Solitary Waves for the Nonlinear Klein-Koedon-Maxwell and Schro dinger-Maxwell Equations显示文摘 | APRILE T D MUGNAI D | 2004 | Proc Roy Soc Edinburgh Sect A2004，，134： | 1 |
| 9 | On Bound States Concentrating on Spheres for the Maxwell-Schrodinger Equations 显示文摘 | APRILE T D WEI J C | 2005 | SIAM J Math Anal2005，，37： | 1 |
| 10 | Factors that affect func- tional status in patients with cancer related pain显示文摘 | April HV Thomas T Susan MH el al | 2007 | I''ain2007，132，12： | 1 |
| 11 | 查看详情显示文摘 | D'Aprile T Pistoia A | | 0，，： | 1 |
| 12 | American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoar- thrifts of the hand, hip, and knee显示文摘 | Hochberg M C Aitman R D April K T eZ aZ | 2012 | Arthritis Care Res2012，64，4： | 1 |
| 13 | American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee 显示文摘 | HOCHBERG M C ALTMAN R D APRIL K T | 2012 | Arthritis care & research2012，64，4： | 1 |
| 14 | Effect of practice on brain activity:an investigation in top-level rifle shooters显示文摘 | Di Russo F Pitzalis S Aprile T | 2005 | Med Sci Sports Exerc2005，37，： | 1 |
| 15 | Existence of solitary waves for the nonlinear Klein - Kordon - Maxwell and Schodinger - Maxwell equations显示文摘 | Aprile T D Mugnai D | 2004 | Proc Roy Soc Edinburgh2004，134，： | 1 |
| 16 | Functional genomic analysis of the A UXIN/INDOLE-3-ACET1C ACID gene family members in Arabidopsis thaliana显示文摘 | Paul J O Yoko O Jos6 M A April C Chang C Joseph R E Beth H Liu A Courtney O Hong Q Alison S Yu G X Athanasios T | 2005 | Plant Cell2005，，17： | 1 |
| 17 | On bound states concentrating on spheres for the Maxwell- Sehrtidinger equation 显示文摘 | Aprile T D Wei J C | 2005 | SIAM J Math Anal2005，37，： | 1 |
| 18 | Standing waves in the Schrsdinger- Maxwell equation and an optimal configuration problem 显示文摘 | Aprile T D Wei J C | 2006 | Calc Var Partial Diff Eqns2006，25，： | 1 |
| 19 | Solitary Waves for Nonlinear Klein-Gordon-Maxwell and Schr6dinger Maxwell Equations 显示文摘 | APRILE T D MUGNAI D | 2004 | Proceedings of the Royal Society of Edinburgh2004，134，5： | 1 |
| 20 | Non-existence results for the coupled Klein-Gordon-Maxwell equations显示文摘 | D' Aprile T Mugnai D | 2004 | Advanced Nonlinear Studies2004，4，： | 1 |
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