|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of innate immunity in the development of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most common form of liver cancer worldwide.It is caused by a variety of risk factors,most common ones being infection with hepatitis viruses,alcohol,and obesity.HCC often develops in the background of underlying cirrhosis,and even though a number of interventional treatment methods are currently in use,recurrence is fairly common among patients who have had a resection.Therefore,whole liver transplantation remains the most practical treatment option for HCC.Due to the growing incidence of HCC,intense research efforts are being made to understand cellular and molecular mechanisms of the disease so that novel therapeutic strategies can be developed to combat liver cancer.In recent years,it has become clear that innate immunity plays a critical role in the development of a number of liver diseases,including HCC.In particular,the activation of Toll-like receptor signaling results in the generation of immune responses that often results in the production of proinflammatory cytokines and chemokines,and could cause acute inflammation in the liver.In this review,the current knowledge on the role of innate immune responses in the development and progression of HCC is examined,and emerging therapeutic strategies based on molecular mechanisms of HCC are discussed. | Rajagopal N Aravalli | 2013 | World Journal of Gastroenterology2013，19，43： | 8 |
| 2 | Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing显示文摘AIM:To identify the genes induced and regulated by the MYC protein in generating tumors from liver stem cells.METHODS:In this study,we have used an immortal porcine liver stem cell line,PICM-19,to study the role of c-MYC in hepatocarcinogenesis.PICM-19 cells were converted into cancer cells(PICM-19-CSCs)by overexpressing human MYC.To identify MYC-driven differential gene expression,transcriptome sequencing was carried out by RNA sequencing,and genes identified by this method were validated using real-time PCR.In vivo tumorigenicity studies were then conducted by injecting PICM-19-CSCs into the flanks of immunodeficient mice.RESULTS:Our results showed that MYC-overexpressing PICM-19 stem cells formed tumors in immunodeficient mice demonstrating that a single oncogene was sufficient to convert them into cancer cells(PICM-19-CSCs).By using comparative bioinformatics analyses,we have determined that>1000 genes were differentially expressed between PICM-19 and PICM-19-CSCs.Gene ontology analysis further showed that the MYCinduced,altered gene expression was primarily associated with various cellular processes,such as metabolism,cell adhesion,growth and proliferation,cell cycle,inflammation and tumorigenesis.Interestingly,six genes expressed by PICM-19 cells(CDO1,C22orf39,DKK2,ENPEP,GPX6,SRPX2)were completely silenced after MYC-induction in PICM-19-CSCs,suggesting that the absence of these genes may be critical for inducingtumorigenesis.CONCLUSION:MYC-driven genes may serve as promising candidates for the development of hepatocellular carcinoma therapeutics that would not have deleterious effects on other cell types in the liver. | Rajagopal N Aravalli Neil C Talbot Clifford J Steer | 2015 | World Journal of Gastroenterology2015，21，7： | 3 |
| 3 | Toll like receptor 2 signa ling is a mediator of apoptosis in herpes simplex virus-infected mi croglia显示文摘 | Aravalli RN Hu S Lokensgard JR | 2007 | J Neuroinflammation2007，4，： | 1 |
| 4 | Osmotic and cytotoxic study of vitr- ification of immature bovine oocytes显示文摘 | ARAV A SHEHU D MATYIOLI M | 1993 | Reprod Fertil1993，99，： | 1 |
| 5 | A new device and method for vitrification increases the cooling rate and allows successful cryopreservation of bovineoocytes 显示文摘 | Arav A Zeron Y Ocheretny A | 2000 | Theriogenology2000，53，3： | 1 |
| 6 | Phase transition temperature and chilling sensitivity of bovine oocytes 显示文摘 | Arav A Zeron Y Leslie S B | 1996 | Clyobiology1996，33，： | 1 |
| 7 | Current progress in oocyte and embryo cryopreservation by slow freezing and vitrification 显示文摘 | Saragusty J Arav A | 2011 | Reproduction2011，141，： | 1 |
| 8 | Hypotherma protection: a fundamental property of antifreeze proteins显示文摘 | Rubinsky B Arav A Fletcher G L | 1991 | Biochem Biophys Res Comm1991，，： | 1 |
| 9 | Cytomegalovirus (HCMV) -encoded UL144 (truncated tumor necrosis factor receptor) arid outcome of congenital HCMV infection显示文摘 | Arav - Boger R Battaglia CA Lazzarotto T | 2006 | J Infect Dis2006，194，4： | 1 |
| 10 | Vitrification of oocytes : from basic sci- ence to clinical application 显示文摘 | Arav A Natan Y | 2013 | Adv Exp Med Biol2013，761，： | 1 |
| 11 | Cryopreservation of oocytes and embryos显示文摘 | Arav A | 2014 | Theriogenology2014，81，： | 1 |
| 12 | Differential apoptotic signaling in primary glial cells infected with herpes simplex virus 1 显示文摘 | Aravalli RN Hu S Rowen TN | 2006 | J Neurovirol2006，12，6： | 1 |
| 13 | Twin pregnancy after vitrification of 2-pronuelei human embryos显示文摘 | Jelinkova L Selman H A Arav A | 2002 | Fertil Steril2002，76，2： | 1 |
| 14 | Effect of treatment with follicle-stimulating hormone or bovine so-matotropin on the quality of oocytes aspirated in the autumn from previously heat-stressed cows 显示文摘 | Roth Z Arav A Braw-Tai R | 2002 | J Dairy Sci2002，85，： | 1 |
| 15 | Twin pregnancy after vitrification of 2-pronuclei human embryos显示文摘 | Jelinkova L Selman H A Arav A | 2002 | Fertil Steril2002，76，2： | 1 |
| 16 | Growth of Gram-negative bacteria in the presence of organic solvents显示文摘 | Rajagopal | 1996 | Enzyme & Microb technology1996，19，： | 1 |
| 17 | Membrane lipid ther- mobehavior of IVE and parthenogenetic bovine embryos 显示文摘 | ARAV A ZERON Y OCHERTNY A | 1999 | Ther- iogenology1999，51，： | 1 |
| 18 | Number of oocytes obtained from cows by OPU in early,but not late lactation inc~ased with plasma insulin and estradiol concentrations and expression of mRNA of the FSH receptor in granulosa calls显示文摘 | Argov N Arav A Sklan D | 2004 | Theriogenolo- gy2004，61，5： | 1 |
| 19 | A new device and method for vitrification increase the cooling rate and allows successful cryopreservation of bovine oocytes 显示文摘 | Arav A Zeron Y Ocheretny A | 2000 | Theriogenology2000，53，： | 1 |
| 20 | Molecular mechanisms of hepatocellular Carcinoma 显示文摘 | ARAVALLI R N STEER C J CRESSMAN E N | 2008 | Hepatology2008，48，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员