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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Transarterial chemoembolization for liver metastases from solid pseudopapillary epithelial neoplasm of pancreas: A case report显示文摘Solid pseudo-papillary epithelial neoplasm(SPEN) is a rare epithelial tumor of pancreas with a low malignant potential occurs most commonly in young females. We report a case of 40 years old woman presented withextensive liver metastasis from SPEN of pancreatic body for which she was operated four years ago. Due to the extensive nature of metastatic disease she was offered Transarterial chemoembolisation(TACE) using gemcitabine as chemotherapeutic agent. Short term follow up after a month of TACE with multiphase computed tomography showed > 90% resolution in the viable tumor with significant clinical improvement. TACE ensures targeted delivery of chemotherapeutic drugs in higher doses with least systemic toxicity and is more effective and safe than systemic chemotherapy. TACE with gemcitabine was found to be very effective in our patient with numerous liver metastasis. | TV Prasad KS Madhusudhan Deep N Srivastava Nihar R Dash Arun K Gupta | 2015 | World Journal of Radiology2015，7，3： | 5 |
| 3 | Climate change adaptation, greenhouse gas mitigation and economic profitability of conservation agriculture: Some examples from cereal systems of Indo-Gangetic Plains显示文摘Achieving sustainability of the cereal system in the Indo-Gangetic Plains(IGP)of India under progressive climate change and variability necessitates adoption of practices and technologies that increase food production,adaptation and mitigation in a sustainable way.This paper examines conservation agriculture(CA)from the perspective of:(i)increased yield and farm income,(ii)adaptation to heat and water stresses,and(iii)reduction in greenhouse gas(GHGs)emissions.The analyses and conclusions are based on the literature and evidences from a large number of on-station as well as farmers’field trials on CA in the cereal systems of IGP.Our analyses show that CA-based system substantially reduces the production cost(up to 23%)but produces equal or even higher than conventional system;thereby increasing economic profitability of production system.CA-based production systems also moderated the effect of high temperature(reduced canopy temperature by 1–4°C)and increased irrigation water productivity by 66–100%compared to traditional production systems thus well adapting to water and heat stress situations of IGP.Our continuous monitoring of soil flux of CO2,N2O and CH4 revealed that CA-based rice-wheat systems emit 10–15%less GHGs than conventional systems.This is the first time that CA and its components are synthesized and analyzed from food security-climate change nexus.From this holistic analysis,we suggest that wide-scale promotion of suitable CA practices by integrating into national agriculture development strategy is a way forward to address food security,climate change adaptation and mitigation challenges faced by present agriculture. | Tek B Sapkota M L Jat Jeetendra P Aryal R K Jat Arun Khatri-Chhetri | 2015 | Journal of Integrative Agriculture2015，14，8： | 4 |
| 4 | Shock wave mitigation using zig-zag structures and cylindrical obstructions显示文摘The present study focuses on the mitigation of shock wave using novel geometric passages in the flow field.The strategy is to produce multiple shock reflections and diffractions in the passage with minimum flow obstruction,which in turn is expected to reduce the shock wave strength at the target location.In the present study the interaction of a plane shock front(generated from a shock tube)with various geometric designs such as,1)zig-zag geometric passage,2)staggered cylindrical obstructions and 3)zigzag passage with cylindrical obstructions have been investigated using computational technique.It is seen from the numerical simulation that,among the various designs,the maximum shock attenuation is produced by the zig-zag passage with cylindrical obstructions which is then followed by zig-zag passage and staggered cylindrical obstructions.A comprehensive investigation on the shock wave reflection and diffraction phenomena happening in the proposed complex passages have also been carried out.In the new zig-zag design,the initial shock wave undergoes shock wave reflection and diffraction process which swaps alternatively as the shock front moves from one turn to the other turn.This cyclic shock reflection and diffraction process helps in diffusing the shock wave energy with practically no obstruction to the flow field.It is found that by combining the shock attenuation ability of zig-zag passage(using shock reflection and diffraction)with the shock attenuation ability of cylindrical blocks(by flow obstruction),a drastic attenuation in shock strength can be achieved with moderate level of flow blocking. | Arun Kumar R Vaibhav Pathak | 2021 | Defence Technology(防务技术)2021，17，6： | 2 |
| 5 | Structural and luminescence enhancement properties of Eu^(3+)/Ag nanocrystallites doped SiO_2-TiO_2 matrices显示文摘We reported here the structural and optical characterisation of silver nanocrystallites/Eu3+ :SiO2-TiO2 matrices synthesised through sol-gel route. Structural characterisations were done by using energy dispersive spectroscopy (EDX), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), atomic force microscope (AFM) and transmission electron microscopy (TEM) measurements and optical characterisations were performed by absorption and emission spectroscopy. The TEM and XRD measurements confirmed the presence of nanocrystals. A broad absorption band was observed due to surface plasmon resonance of silver nanocrystals. The effect of silver nanocrystals on the emission spectrum of Eu3+ doped SiO2-TiO2 matrices was discussed. An attempt was made to explain this fluorescence enhancement by invoking phenomena such as energy transfer, asymmetry ratio, surface plasmon, surface roughness, crystallinity and grain boundary. Our analysis, based on the experimental results, suggested that all the phenomena except crystallinity and grain boundary had favourable effects on fluorescence enhancement. We also estimated the relevant parameters associated with the phenomena that affected the fluorescence emission from the Eu3+ ions in the matrix. It was seen that the theoretical estimate of fluorescence enhancement agreed well with the experimental estimate. | Arun Kumar K V Revathy K P Prathibha Vasudevan Sunil Thomas Biju P R Unnikrishnan N V | 2013 | Journal of Rare Earths2013，31，5： | 2 |
| 6 | Pain management in mice using methanol extracts of three plants belongs to family Amaranthaceae显示文摘Objective:To investigate the analgesic activity of methanolic extract of Amaranthus viridis(A. viridis),Amaranthus caudatus(A.caudatus) and Amaranthus spinosus(A.spinosus).Methods:In this study,the analgesic activity of methanol extracts of all three plants at doses of 200 and 400 mg/kg were investigated by acetic acid-induced writhings test,hot plate test and tail immersion test for mice.Results:It was found that all the three plants showed significant pain management effect(P<0.01) at a dose of 400 mg/kg,but showed a less significant effect at a dose of 20 mg/kg in the entire tests used for evaluation of analgesic activities(P<0.05).Conclusions:Methanol extracts of A.viridis,A.caudatus and A.spinosus show potent analgesic activities,and this study provides the scientific proof for their traditional claims. | Ashok Kumar BS Lakshman K Jayaveera KN Vel Murgan C Arun Kumar PA Vinod Kumar R Meghda Hegade Sridhar SM | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，7： | 2 |
| 7 | 碱炉高效运行与维护实践显示文摘随着当前能源需求量的急速增长以及对环保要求的不断增强,造纸厂已经将安全和环保问题纳入到方针和行动的各个方面,如造纸厂着力于探索一些能够增强碱炉安全、环保、高效、高开机率的全局性改善措施。探索实践的内容如:熔融物抽取系统、自动清理风口系统、利用安全检修平台进行检修、有味气体的处理和焚烧、先进的工艺控制、先进的安全联锁等都在本文中有相关介绍。 | 于英民 Chandrasekaran R Arun A Mishra Anshul Raju R Ravishangar P S | 2013 | 中华纸业2013，34，14： | 2 |
| 8 | Economic incentives for agricultural nonpoint source pollution control显示文摘 | Bruce A L Marc R | 1994 | Water Resources Bulletin1994，30，3： | 1 |
| 9 | Tensile and elastic properties of tri-block copolymer based on aramide end-segments and po!yethermid- segments显示文摘 | Arun A Gaymans R J | 2009 | Journal of Applied Polymer Science2009，111，4： | 1 |
| 10 | Distinct patterns of expression of traumatic brain injury biomarkers after blast exposure: role of compromised cell membrane integrity显示文摘 | Arun P Abu-Taleb R Oguntayo S | 2013 | Neurosci Lett2013，27，552： | 1 |
| 11 | A safe controlled instrumented reduc-tion technique for cervical osteotomy in ankylosing spondyli- tis显示文摘 | Mehdian S Arun R | 2011 | Spine2011，36，9： | 1 |
| 12 | Breeding crops for reduced-tillage management in the intensive,rice-wheat systems of South Asia显示文摘 | JOSHI A K CHAND R ARUN B | 2007 | Euphytica2007，153，： | 1 |
| 13 | Correlation for cylinder-to-bed heat transfer in aerated vibrated beds of small particles 显示文摘 | ECCLES E R MUJUMDAR A ARUN S | 1992 | Drying Technology1992，10，1： | 1 |
| 14 | Kellgren-Lawrence (K-L) scores and arthroscopic findings in the degenerative knee 显示文摘 | Arun J Ramappa J Steadman R | 2006 | J Bone Joint Surg Br2006，88，1： | 1 |
| 15 | Defective N - acety- laspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease 显示文摘 | Madhavarao C N Arun P Moffett J R | 2005 | Proc Natl Acad Sci U S A2005，102，14： | 1 |
| 16 | Nuclear NF-κB p65 Phos-phorylationat Serine 276 by Protein KinaseA Contributes to the MalignantPhenotype of Head and Neck Cancer显示文摘 | ARUN P BROWN M B EHSANIAN R | 2009 | Clin Cancer Res2009，15，： | 1 |
| 17 | Liquid -liquid equilibria measurement of systems involving alkanes (heptane and dodecane ), aromatics (benzene or toluene) and furfural显示文摘 | Arun Kumar U K Mohan R | 2011 | Journal of Chemical and Engineering Data2011，56，： | 1 |
| 18 | Unusual presentation of warthin variant of papillary thyroid carcinoma with lymph nodal metastases in a patient of graves’ disease显示文摘 | Padma S Sundaram P S Arun B R | 2015 | J Cancer Res Ther2015，11，3： | 1 |
| 19 | Performance analysis of WDM optical networks with wavelength usage constraint 显示文摘 | Jing Fang Srinivasan R Somani Arun K | 2003 | Photonic Network Communications2003，5，2： | 1 |
| 20 | Quinary and eight-component liquid-liquid equilibria of mixtures of alkanes, aromatics, and solvent (furfural) 显示文摘 | Arun Kumar U K Mohan R | 2013 | Journal of Chemical and Engineering Data2013，58，： | 1 |
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