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| 1 | Pathophysiology and prevention of postoperative peritoneal adhesions显示文摘Peritoneal adhesions represent an important clinical challenge in gastrointestinal surgery. Peritoneal adhesions are a consequence of peritoneal irritation by infection or surgical trauma, and may be considered as the pathological part of healing following any peritoneal injury, particularly due to abdominal surgery. The balance between fi brin deposition and degradation is critical in determining normal peritoneal healing or adhesion formation. Postoperative peritoneal adhesions are a major cause of morbidity resulting in multiple complications, many of which may manifest several years after the initial surgical procedure. In addition to acute small bowel obstruction, peritoneal adhesions may cause pelvic or abdominal pain, and infertility. In this paper, the authors reviewed the epidemiology, pathogenesis and various prevention strategies of adhesion formation, using Medline and PubMed search. Several preventive agents against postoperative peri-toneal adhesions have been investigated. Their role aims in activating fi brinolysis, hampering coagulation, diminishing the inflammatory response, inhibiting col-lagen synthesis or creating a barrier between adjacentwound surfaces. Their results are encouraging but most of them are contradictory and achieved mostly in animal model. Until additional fi ndings from future clinical researches, only a meticulous surgery can be recommended to reduce unnecessary morbidity and mortality rates from these untoward effects of surgery. In the current state of knowledge, pre-clinical or clini-cal studies are still necessary to evaluate the effective-ness of the several proposed prevention strategies of postoperative peritoneal adhesions. | Willy Arung Michel Meurisse Olivier Detry | 2011 | World Journal of Gastroenterology2011，17，41： | 46 |
| 2 | Effects of parecoxib on the prevention of postoperative peritoneal adhesions in rats 显示文摘 | Arung W Jehaes F Cheramy JP | 2013 | J Invest Surg2013，26，6： | 1 |
| 3 | Inhibitory effect of artocarpanone from Artocarpus heterophyllus on melanin biosynthesis 显示文摘 | Arung E T Shimizu K Kondo R | 2006 | Biol Pharm Bull2006，29，： | 1 |
| 4 | 3-Prenylluteolin, a new prenylated flavone with melanin biosynthesis inhibitory activity from wood of Artoearpus heterophyllus 显示文摘 | Arung E T Shimizu K Tanaka H | 2010 | Fitoterapia2010，81，： | 1 |
| 5 | Isoprenoid-substituted flavonoids from wood of Artocarpus heterophyllus on B16 melanoma celis: Cytotoxicity and structural criteria 显示文摘 | Enos Tangke Arung Keisuke Yoshikawa Kuniyoshi Shimizu | 2010 | Fitoterapia2010，81，2： | 1 |
| 6 | Inhibitory effect of isoprenoid- substituted flavonoids isolated from Artocarpus heterophylluson melanin biosynthesis显示文摘 | Arung E T Shimizu K Kondo R | 2006 | Planta Med2006，72，： | 1 |
| 7 | 3-Prenyl luteolin, a new prenylated flavone with melanin biosynthesis inhibitory activity from wood of Artocarpus heterophyllus 显示文摘 | Arung E T Shimizu K Tanaka H | 2010 | Fitoterapia2010，81，6： | 1 |
| 8 | Cytotoxic effect of artocarpin on T47D cells显示文摘 | Arung E T Wicaksono B D Handoko Y A | 2010 | J Nat Med2010，64，： | 1 |
| 9 | Pathophysiology and prevention of postoperative peritoneal adhesions 显示文摘 | Arung W Meurisse M Detry O | 2011 | World journal of gastroenterology : WJG2011，，17： | 1 |
| 10 | Inhibitory components from the buds of clove (Syzygium aromaticum ) on melanin formation in B16 melanoma cells 显示文摘 | ARUNG E T MATSUBARA E KUSUMA I W | 2011 | Fitoterapia2011，82，2： | 1 |
| 11 | Antiproliferative effect of the methanol extract of Piper crocatum ruiz &pav leaves on human breast (T47D) cells in vitro 显示文摘 | Wicaksono BD Handoko YA Arung ET | 2009 | Trop J Pharm Res2009，8，4： | 1 |
| 12 | Effeets of pareeoxib on the prevention of postoperative peritoneal adhesions in rats 显示文摘 | Arung W Jehaes F Cheramy JP | 2013 | Journal of Investigative Surgery2013，26，6： | 1 |
| 13 | Structure-activity relationship of prenyl-substituted polyphenols from Artocarpus heterophyllus as inhibitors of melanin biosynthesis in cultured melanoma cells 显示文摘 | Arung ET Shimizu K Kondo R | 2007 | Chem Biodivers2007，4，9： | 1 |
| 14 | Correction of duplex sonography with arteriography in patients with erectile dysfunction显示文摘 | Benson CB Arung JE Vickers MA | 1993 | AJR1993，160，1： | 1 |
| 15 | Inhibitory effect of isoprenoid-substituted flavonoids isolated from Artocarpus heterophyllus on melanin biosynthesis显示文摘 | Arung ET Shimizu K Kondo R | 2006 | Planta Med2006，72，9： | 1 |
| 16 | Inhibitory effect of artocarpanone from Artocarpus heterophyllus on melanin biosynthesis 显示文摘 | Arung ET Shimizu K Kondo R | 2006 | Biol Pharm Bull2006，29，9： | 1 |
| 17 | Inhibitory effect of artocarpanone from A rtocarpus heterophyllus on melanin biosynthesis显示文摘 | Arung E T Shimizu K Kondo R | 2006 | Biol Pharm Bull2006，29，9： | 1 |
| 18 | Inhibitory components from the buds of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells显示文摘 | Arung ET Matsubara E Kusuma IW Sukaton E Shimizu K Kondo R | 2011 | Fitoterapia2011，82，2： | 1 |
| 19 | Antidennatophyte and antimel- anogenesis compound from Eleutherine americana grown in Indonesia 显示文摘 | Kusuma I W Arung E T Rosamah E | 2010 | J Nat Med2010，64，2： | 1 |
| 20 | Effects of Parecoxib on ThePrevention of Postoperative Peritoneal Adhesions in Rats显示文摘 | Arung W Jehaes F5Cheramy JP | 2013 | J InvestSuig2013，8，2： | 1 |
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