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| 1 | Role of polyethylene particles in peri-prosthetic osteolysis:A review显示文摘There is convincing evidence that particles produced by the wear of joint prostheses are causal in the periprosthetic loss of bone,or osteolysis,which,if it progresses,leads to the phenomenon of aseptic loosening.It is important to fully understand the biology of this bone loss because it threatens prosthesis survival,and loosened implants can result in peri-prosthetic fracture,which is disastrous for the patient and presents a difficult surgical scenario.The focus of this review is the bioactivity of polyethylene(PE)particles,since there is evidence that these are major players in the development and progression of osteolysis around prostheses which use PE as the bearing surface.The review describes the biological consequences of interaction of PE particles with macrophages,osteoclasts and cells of the osteoblast lineage,including osteocytes.It explores the possible cellular mechanisms of action of PE and seeks to use the findings to date to propose potential nonsurgical treatments for osteolysis.In particular,a nonsurgical approach is likely to be applicable to implants containing newer,highly cross-linked PEs(HXLPEs),for which osteolysis seems to occur with much reduced PE wear compared with conventional PEs.The caveat here is that we know little as yet about the bioactivity of HXLPE particles and addressing this constitutes our next challenge. | Gerald J Atkins David R Haynes Donald W Howie David M Findlay | 2011 | World Journal of Orthopedics2011，2，10： | 11 |
| 2 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | The Lancet2010，，9726： | 4 |
| 3 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | 2010 (9726)2010，，9726： | 3 |
| 4 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | The Lancet . 2010 (9726)2010，，： | 2 |
| 5 | Influence of the carrier on the catalytic performance of impregnated phosphoric acid in the hydration of ethylene显示文摘 | atkins M P Wolderich W F | 1999 | Applied catalysis A:general1999，181，1： | 1 |
| 6 | A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis显示文摘 | JONKER Johan W MYOUNG SUH Jae ATKINS Annette R | | 0，，7398： | 1 |
| 7 | Protection in animal models of brain and spinal cord injury with mild to moderate hypothermia 显示文摘 | DIETRICH W D ATKINS C M Bramlett H M | 2009 | J Neurotranma2009，26，3： | 1 |
| 8 | Information consensus in mul- tivehicle cooperative control: Collective group behavior through lo- cal interaction 显示文摘 | WRen R W Beard E M Atkins | 2007 | IEEE Control Systems Magazine2007，27，2： | 1 |
| 9 | Intraeardlae trans- plantation of skeletal myoblasts yields two populations of striat- ed cells in situ显示文摘 | Atkins B Z Lewis C W Kraus W E | 1999 | Ann Thorac Surg1999，67，1： | 1 |
| 10 | Information consensus in multivehicle cooperative control 显示文摘 | REN W BEARD R W ATKINS E M | 2007 | IEEE Control Systems Maga- zine2007，27，2： | 1 |
| 11 | Distributed multi-vehicle coordinated con- trol via local information exchange显示文摘 | REN W ATKINS E M | 2007 | International Journal of Ro- bust and Nonlinear Control2007，17，1011： | 1 |
| 12 | The impact of a shock wave on porous compressible foams 显示文摘 | Skews B W Atkins M D Seitz M W | 1993 | Journal of Fluid Mechanics1993，253，1： | 1 |
| 13 | Colorectal cancer显示文摘 | CUNNINGHAM D ATKIN W LENZ H J | 2010 | Lancet2010，375，10： | 1 |
| 14 | Characteristics andoutcomes of patients who SeIf-extubate from ventilatow suppart : acasecontml study显示文摘 | Atkins PM Mion LC Mendelson W et a1 | 1997 | Chest1997，112，5： | 1 |
| 15 | &99mTc-gelatin:a 'compound'with high renal specificity显示文摘 | Lebowitz E Atkins HL Hauser W | 1971 | Int J Appl Radiat Isot1971，22，12： | 1 |
| 16 | Distributed multi-vehicle Coordina- ted control via local Information exchange 显示文摘 | REN W ATKINS E | 2007 | Robust Nonlinear Control2007，17，1011： | 1 |
| 17 | A PPAR-FGF1 axis is re- quired for adaptive adipose remodelling and metabolic homeostasis 显示文摘 | Jonker J W Suh J M Atkins A R | 2012 | Nature2012，485，7398： | 1 |
| 18 | The proliferation and phenotypic expression of human osteoblasts on tantalum metal显示文摘 | David M Findlay Katie Welldon Gerald J Atkins Donald W Howie Andrew C.W Zannettino Dennis Bobyn | 2003 | Biomaterials2003，，12： | 1 |
| 19 | Randomized Phase Ⅱ study of multiple does levels of CCI -779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinomas显示文摘 | ATKINS M B HIDALGO M STADLER W M | 2004 | J Clin Oncol2004，22，： | 1 |
| 20 | Consensus seeking in multiagent systems under dynamically changing interaction topologies显示文摘 | Ren W Atkins E | | 0，，50： | 1 |
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