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| 1 | Depression in patients with irritable bowel syndrome in Jos,Nigeria显示文摘AIM: To study the brain-gut interaction and the effect of behavioral or psychiatric conditions on irritable bowel syndrome (IBS) in an African population. METHODS: IBS was diagnosed using the Rome Ⅱ diagnostic criteria. The entry of each patient was confirmed following detailed explanations of the questions. Four hundred and eighteen patients were studied. Subjects satisfying the Rome Ⅱ criteria for IBS were physically examined and stool microscopy was done to identify the presence of “alarm factors”. Depression was diagnosed using the symptom-check list adapted from the Research Diagnostic Criteria (DSM-Ⅳ) of the American Psychiatric Association. RESULTS: Seventy-five (56.8%) of the 132 IBS patients were depressed whereas only 54 (20.1%) of the 268 non-IBS patients were depressed. There was a significant relationship between IBS and depression (χ2 = 54.29, Odds ratio = 5.21, 56.8 ± 8.4 vs 20.1 ± 5.2, P = 0.001). Even though constipation predominant IBS patients were more likely to be depressed, no significant relationship was found between the subtype of IBS and depression (χ2 = 0.02, OR = 0.95, P = 0.68). CONCLUSION: IBS is significantly associated with major depression but not gender and bowel subtypes of the patients. Patients with IBS need to be evaluated for depression due to the highly significant relationship between the two conditions. | Nimzing G Ladep Taiwo J Obindo Moses D Audu Edith N Okeke Abraham O Malu | 2006 | World Journal of Gastroenterology2006，12，48： | 22 |
| 2 | Formulation and evaluation the bioadhesive properties of drug delivery system based on PEGylated mucin matrices显示文摘Objective:To formulate and evaluate the application of PEGylated mucin in oral bioadhesive drug(OBD) delivery system.Methods:The bioadhesive strength of different formulation ratios of polyethylene glycol(PEG) and mucin was evaluated by tensiometry.Co polymer matrices containing mucin and PEG(PEGylated mucin) in the following ratios of 1:1(A),2:1(B),1:2(C), 0:1(D) and 1:0(E) were prepared by co-precipitation.Microparticles were prepared from the matrices using a size reduction technique.Five different samples were prepared using direct mixtures in the appropriate solvenfs having mucin and PEG ratios of 1:1,2:1,1:2,0:1, 1:0 and labeled as(A-E).The matrices were evaluated for their flow properties and the in vitro bioadhesion characteristics of the samples were examined.Results:The range of flow rates of the matrices was 1.35-2.23 g/sec.The angle of repose was in the range of 37.3-39.9 degree.The bulk and tapped densities were within the ranges of 0.41- 0.49.The Hausner’s quotient(HQ) were 1.12, 1.24,1.14,1.25 and 1.2 for matrix batches A-E respectively,The bioadhesive strength of polymer matrices appeared to be directly related to amount of mucin.The order of bioadhesive strength is 2:1>1:1>1:0>1:2>0:1 of PEG:mucin in both simulated intestine fluid(SEP) and simulated gastrointestinal fluid(SGF).The physical properties of the micrometrics properties of the matrices were within the accepted values.Conclusions:OBD preparation containing PEGylated mucin can be prepared by direct compression and be used in drug delivery to the oral cavity. | Momohmumuni Audu Adikwu Michael Umale Ibezim Emmanuel Chinnedu | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，6： | 3 |
| 3 | Effects of poly(ethylene glycol) on efflux transporter activity in Caco-2 cell monolayem显示文摘 | Audus KL Borehardt RT | 2002 | J Pharm Sci2002，91，9： | 1 |
| 4 | Magnetotropism: a new plant growth response显示文摘 | AUDUS L J | 1960 | Nature1960，185，： | 1 |
| 5 | Asymmetric postoperative visual loss after spine surgery in the lateral decubitus position 显示文摘 | Heitz JW Audu PB | 2008 | Br J Anesth2008，101，3： | 1 |
| 6 | Reevaluation of surgery for the treatment of brain metastases: review of 208 patients with single or multiple brain metastases treated at one institution with modern neurosurgical techniques显示文摘 | Paek SH Audu PB Sperling MR | 2005 | Neurosurgery2005，56，5： | 1 |
| 7 | Controlling drug delivery across the placenta显示文摘 | Audus K L | 1999 | Eur J Pharm Sci1999，8，3： | 1 |
| 8 | Nitric oxide and blood-brain barrier integrity 显示文摘 | Thiel VE Audus KL | 2001 | Antloxid Redox Signal2001，3，： | 1 |
| 9 | Expression and functional activities of selected sulfotransferase isoforms in BeWo cells and primary cytotrophoblast cells 显示文摘 | Mitra P Audus KL | 2009 | Biochem Pharmacol2009，78，12： | 1 |
| 10 | Comparison of the effect of potential parenteral vehicles for poorly water soluble anticaneer drugs on cultured endothelial cells显示文摘 | Medlicott NJ Foster KA Audus KL | 1998 | J Pharm Sci1998，87，9： | 1 |
| 11 | Microbial isolates and antibiogram from endocervical swabs of patients with pelvic inflammatory disease 显示文摘 | Audu BM Kudi AA | 2004 | J Obstet Gynaecol2004，24，2： | 1 |
| 12 | Nitric oxide and blood-brain barrier integrity显示文摘 | Thiel VE Audus KL | 2001 | Antioxid Redox Signal2001，3，2： | 1 |
| 13 | Modulation of P-glycoprotein activity in Calu-3 cells using steroids and beta-ligands显示文摘 | Yazdanian M A Audus K L | 2001 | Int J Pharm2001，228，12： | 1 |
| 14 | Efflux transporter of the human placenta显示文摘 | A M Young C E Allen K L Audus | | 0，，： | 1 |
| 15 | Effect of bisphenol A on drug efflux in BeWo, a human trophoblast - like cell line 显示文摘 | Jin H Audus KL | 2005 | Placenta2005，，： | 1 |
| 16 | Permeability properties of monolayers of the human trophoblast cell line BeWo显示文摘 | Fei Liu Michael J Soares Kenneth L Audus | | 0，，： | 1 |
| 17 | Leucine enkephalin effects on paracellular and transcdlular permeation pathwaysacross brain microvessd endothelial cell monolayers 显示文摘 | Thompson SE Cavitt J Audus KI | 1994 | Cardivase Pharma Col1994，34，24： | 1 |
| 18 | Nitric oxide and blood-brain barrier integrity 显示文摘 | Thiel VE Audus KL | 2001 | Antioxid Redox Signal2001，3，2： | 1 |
| 19 | Nitric oxide and blood - brain barrier integrity显示文摘 | Thiel VE Audus KL | 2001 | Antioxid Redox Signal2001，3，2： | 1 |
| 20 | Evidence for 21 - aminosteroid association with the hydrophobic domains of brain microvessel endothelial cells显示文摘 | Audus KL Guillot FL Brauglder JM | 1991 | Free Radic Bio Med1991，11，： | 1 |
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