|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | X-ray interactions: photabsorption, scattering, transmission, and reflection at E-50-30000 eV, Z=1-92显示文摘 | HENKE B L GULLIKSON E M DAVIS J C | 1993 | Atomic Data and Nuclear Tables1993，54，： | 2 |
| 3 | Distribution of volcanic sediments in the Golf coastal Province-significance to petroleum geology显示文摘 | Davis D K | 1979 | Transactions Golf Coast Association of Geological Societies1979，29，1： | 1 |
| 4 | Seasonal variations of trace metal chemical forms in bed sediments of a karstic river in Lebanon: implications for self-purification 显示文摘 | Korfali S I Davies B E | 2005 | Environmental Geochemistry and Health2005，27，： | 1 |
| 5 | Elastin is an essential determinant of arterial morphogenesis显示文摘 | D Y Li B Brooke E C Davis | 1998 | Nature1998，393，21： | 1 |
| 6 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 7 | X-ray interactions: photoabsorption scattering, transmission and reflection at E=50-30000 eV, Z=1-92显示文摘 | HENKE B L GULLIKSON E M DAVIS J C | 1993 | Atomic Data and Nuclear Data Tables1993，54，： | 1 |
| 8 | Improved recovery of coarse Floridaphosphate显示文摘 | Davis B E Hood G D | 1993 | Mining Engineering1993，45，6： | 1 |
| 9 | The autonomous underwater glider 'Spray' 显示文摘 | Sherman J Davis R E Owens W B | 2001 | IEEE Journal of Oceanic Engineering2001，26，4： | 1 |
| 10 | An exploratory study investiga- ting children's perceptions of dental behavioral management techniques 显示文摘 | DAVIES E B BUCHANAN H | 2013 | Int J Paediatr Dent2013，23，4： | 1 |
| 11 | Calcium anidotrihydroborate:a hydrogen storage material显示文摘 | Diyabalanage H V K Shrestha R P Semelsberger TA Scott B L Bowden M E Davis B L Burrell A K | | 0，，47： | 1 |
| 12 | Application of the Australian river bioassessmentsystem ( AUSRIVAS) in the Brantas River, East Java,Indonesia 显示文摘 | Hart B T Davies P E Humphrey C L | | Journal of Environmental Management0，，： | 1 |
| 13 | Chemoprevention of aflatoxin B1 induced genotoxicity and hepatic oxidative damage in rats by kolaviron, a natural biflavonoid of Garcinia kola seeds显示文摘 | Farombi E O Adepoju B F Ola Davies O E | 2005 | Eur J Cancer Prey2005，14，3： | 1 |
| 14 | Fluorescent methods for measuring and imaging cytosolic free Ca^2+ in neutrophils显示文摘 | Hallett M B Davies E V Pettit E J | 1996 | Methods1996，9，3： | 1 |
| 15 | Development of a flux compression power unit for milli-second ETC pulsed power application 显示文摘 | Goldman E B Davies F Bickford J | 1999 | IEEE Trans on Magnetics1999，35，1： | 1 |
| 16 | X-ray interaction:photoabsorption,scattering,transmission and reflection at E=50-30000eV,Z=1-92显示文摘 | HENKE B L GULLIKSEN E M DAVIS J C | 1993 | Atomic Data and Nuclear Data Tables1993，54，2： | 1 |
| 17 | Pharma-cokinetics of oral terbinafine in horses and Greyhound dogs显示文摘 | WILLIAMS M M DAVIS E G KUKANICH B | 2011 | J Vet Pharmacol Ther2011，34，3： | 1 |
| 18 | Cathelicidins: Microbicidal activity, mechanisms of action, and roles in in- nate immunity显示文摘 | Ramanathan B Davis E G Ross C R et a l | 2002 | Microb Infect2002，4，： | 1 |
| 19 | Tackling antibiotic resistance显示文摘 | Bush K Courvalin P Dantas G Davies J Eisenstein B Huovinen P Jacoby GA Kishony R Kreiswirth BN Kutter E Lerner SA Levy S Lewis K Lomovskaya O Miller JH Mobashery S Piddock LJ Projan S Thomas CM Tomasz A Tulkens PM Walsh TR Watson JD Witkowski J Witte W Wr | | 0，，： | 1 |
| 20 | The autonomous underwater glider 'spray' 显示文摘 | SHERMAN J DAVIS R E OWENS W B | 2001 | IEEE Journal of Oceanic Engineering2001，126，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员