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| 1 | Endoscopic balloon catheter dilatation via retrograde or static technique is safe and effective for cricopharyngeal dysfunction显示文摘AIM To evaluate the safety and efficacy of upper esophageal sphincter(UES) dilatation for cricopharyngeal(CP) dysfunction. To determine if:(1) indication for dilatation; or(2) technique of dilatation correlated with symptom improvement.METHODS All balloon dilatations performed at our institution from over a 3-year period were retrospectively analyzed for demographics, indication and dilatation site. All dilatations involving the UES underwent further review to determine efficacy, complications, and factors that predict success. Dilatation technique was separated into static(stationary balloon distention) and retrograde(brusque pull-back of a fully distended balloon across the UES).RESULTS Four hundred and eighty-eight dilatations were reviewed. Thirty-one patients were identified who underwent UES dilatation. Median age was 63 years(range 27-81)and 55% of patients were male. Indications included dysphagia(28 patients), globus sensation with evidence of UES dysfunction(2 patients) and obstruction to echocardiography probe with cricopharyngeal(CP)bar(1 patient). There was evidence of concurrent oropharyngeal dysfunction in 16 patients(52%) and a small Zenker's diverticula(≤ 2 cm) in 7 patients(23%). Dilator size ranged from 15 mm to 20 mm. Of the 31 patients, 11 had dilatation of other esophageal segments concurrently with UES dilatation and 20 had UES dilatation alone.Follow-up was available for 24 patients for a median of 2.5 mo(interquartile range 1-10 mo), of whom 19 reported symptomatic improvement(79%). For patients undergoing UES dilatation alone, follow-up was available for 15 patients, 12 of whom reported improvement(80%).Nineteen patients underwent retrograde dilatation(84%response) while 5 patients had static dilatation(60%response); however, there was no significant difference in symptom improvement between the techniques(P = 0.5).Successful symptom resolution was also not significantly affected by dilator size, oropharyngeal dysfunction,Zenker's diverticulum, age or gender(P > 0.05). The only complication noted was uvular edema and a shallow ulcer after static dilatation in one patient, which resolved spontaneously and did not require hospital admission.CONCLUSION UES dilatation with a through-the-scope balloon by either static or retrograde technique is safe and effective for the treatment of dysphagia due to CP dysfunction. To our knowledge, this is the first study evaluating retrograde balloon dilatation of the UES. | Vinay Chandrasekhara Joyce Koh Lakshmi Lattimer Kerry B Dunbar William J Ravich John O Clarke | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，4： | 6 |
| 2 | Strong association of de novo eopy number mutations with antism显示文摘 | Sebat J Lakshmi B Malhotra D | 2007 | Seience2007，，5823： | 1 |
| 3 | Sol-gel template synthesis of semiconductor nanostructures 显示文摘 | Lakshmi Peter K | 1997 | Chem Mater1997，9，： | 1 |
| 4 | Coexpression of Notchl and NF- kappaB signaling pathway components in human cervical cancer progression 显示文摘 | Ramdass B Maliekal rIFT Lakshmi S | 2007 | Gynecologic Oncology2007，104，2： | 1 |
| 5 | Coexpression of Notchl and NF-kappaB signaling pathway components in human cervical cancer progression显示文摘 | RAMDASS B MALIEKAL TT LAKSHMI S | 2007 | Gynecol Oncol2007，104，2： | 1 |
| 6 | Carbon nanotubule membranes for electrochemical energy storage and production显示文摘 | Che G L Lakshmi B B Fisher E R | | 0，，： | 1 |
| 7 | State of the art report on steel-concrete composite columns显示文摘 | Shanmugam N E Lakshmi B | 2001 | Journal of Construc- tional Steel Research2001，57，10： | 1 |
| 8 | Single-agent arsenic trioxide in the treatment of newly diagnosed aeute myelocytic leukemia:dura-ble remissins with minimal toxicity显示文摘 | Mathews V George B Lakshmi KM | 2006 | {H}Blood2006，，： | 1 |
| 9 | Selection and characterization of β-lactam-β-lactamase inactivator-resistant mutants following PCR mutagenesis of the TEM-1 β-lactamase gene显示文摘 | Sergei B V Bruce G Lakshmi P K | 1998 | Antimicrob Agents Chemother1998，42，： | 1 |
| 10 | Strong association of de novo copy number mutations with autism显示文摘 | Sebat J Lakshmi B Malhotra D | | 0，，5823： | 1 |
| 11 | State of the art report on steel-concrete composite columns显示文摘 | Shanmugam N E Lakshmi B | 2001 | Journal of Constructional Steel Research2001，57，： | 1 |
| 12 | The templated-synthesis of poly nanotubes显示文摘 | Lakshmi B B Patrissi C J Martin C R | 1997 | Chem Mater1997，9，： | 1 |
| 13 | Carbon nanotuble membranes for electrochemical energy storage and production显示文摘 | Che G Lakshmi B B Fisher E R | 1998 | Nature1998，393，： | 1 |
| 14 | Coexpression of Notchl and NF-kappaB signaling pathway components in human cervical progression 显示文摘 | Ramdass B Malickal TT Lakshmi S ct al | 2007 | Gynecol 0ncol2007，104，2： | 1 |
| 15 | Enhanced thermal stability and structural characteristics of different MMT-clay/epoxy nanocomposite materials显示文摘 | Suguna Lakshmi M Narmadha B Reddy B S R | 2008 | Polymer Degra- dation and Stability2008，93，1： | 1 |
| 16 | Sol-Gel Template Synthesis of Semiconductor Nanostructures显示文摘 | Lakshmi B B Dorhout P K Martin C R | 1997 | Chem Mater1997，9，3： | 1 |
| 17 | Carbon Nanotubes Membranes for Electrochemical Energy Storage and Production显示文摘 | Che Guangli Lakshmi B B Fisher E R | 1998 | Nature1998，393，6683： | 1 |
| 18 | Chemistry of sitoxane amide as a new curing agent for epoxy resins: material characterization and properties显示文摘 | Srividhya M Lakshmi M S Reddy B S R | 2005 | Macromo- lecular Chemistry and Physics2005，206，24： | 1 |
| 19 | Studies on Docking Dynamics Using ADAMS' 显示文摘 | Lakshmi N B Ranganath R Nataraju B S | 2000 | Journal of Spacecraft Technology (ISRO Satellite Center)2000，10，1： | 1 |
| 20 | Application of ionic liquid polymeric microsphere inoil field scale control process显示文摘 | LAKSHMI D S SENTHILMURUGAN B DRIOLI E etal | 2013 | Journal of PetroleumScience and Engineering2013，112，： | 1 |
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