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| 1 | Role of PRMTs in cancer: Could minor isoforms be leaving a mark?显示文摘Protein arginine methyltransferases(PRMTs) catalyze the methylation of a variety of protein substrates, many of which have been linked to the development, progression and aggressiveness of different types of cancer. Moreover, aberrant expression of PRMTs has been observed in several cancer types. While the link between PRMTs and cancer is a relatively new area of interest, the functional implications documented thus far warrant further investigations into its therapeutic potential. However, the expression of these enzymes and the regulation of their activity in cancer are still significantly understudied. Currently there are nine main members of the PRMT family. Further, the existence of alternatively spliced isoforms for several of these family members provides an additional layer of complexity. Specifically, PRMT1, PRMT2, CARM1 and PRMT7 have been shown to have alternative isoforms and others may be currently unrealized. Our knowledge with respect to the relative expression and the specific functions of these isoforms is largely lacking and needs attention. Here we present a review of the current knowledge of theknown alternative PRMT isoforms and provide a rationale for how they may impact on cancer and represent potentially useful targets for the development of novel therapeutic strategies. | R Mitchell Baldwin Alan Morettin Jocelyn C té | 2014 | World Journal of Biological Chemistry2014，5，2： | 14 |
| 2 | Hydrogen-oxygen proton-exchange membrane FC and electrolyzres 显示文摘 | Baldwin R | 1990 | Journal of Power Sources1990，29，： | 2 |
| 3 | A quantitative comparison of three grolishing techniques for the precessions TM process显示文摘 | WALKER D D BALDWIN A EVANS R | 2007 | SPIE2007，6671，： | 1 |
| 4 | Temperature of water heat treatments influences tomato fruit quality following low-temperature storage显示文摘 | MEDONALD R E MECOLLUM T G BALDWIN E A | 1999 | Postharvest Biology and Technology1999，16，： | 1 |
| 5 | Aroma perception of individual volatile compounds in fresh tomatoes as affected by the medium of evaluation显示文摘 | Tandon K S Baldwin E A Shewfelt R L | 2000 | Postharv Biol Technol2000，20，： | 1 |
| 6 | Preliminary experience with high-volume hemofiltration in human septic shock显示文摘 | Bellomo R Baldwin I Cole L | 1998 | Kidney Inter1998，53，166： | 1 |
| 7 | Effects of amino acids and peptides on rumen microbial growth yields显示文摘 | ARGYLE J L BALDWIN R L | 1989 | J Dairy Sci1989，72，： | 1 |
| 8 | Estrogen and progesterone receptor subtype expression in normal and malignant ovarian epithelial cell cultures显示文摘 | Li A J Baldwin R L Karlan B Y | 2003 | Am J Obstet Gynecol2003，189，1： | 1 |
| 9 | Stimulation of feeding in the satiated pig by intracerebroventricular injection of NPY显示文摘 | Parrott R T Heavens R P Baldwin B A | 1986 | Physiology and Behavori1986，36，： | 1 |
| 10 | An effective method for evaluating the accuracy of power hardware in-the-loop simulations显示文摘 | WEI R STEURER M BALDWIN T L | 2009 | IEEE Trans on Industry Applications2009，45，4： | 1 |
| 11 | Information - seeking behavior of securities analysts individual and institutional influences, information sources and channels, and outcomes 显示文摘 | Baldwin N S Rice E R | 1997 | Journal of the American Society for Information Science1997，48，8： | 1 |
| 12 | Measurable dynamic gains from trade 显示文摘 | Baldwin R E | 1992 | Journal of Political Economy1992，100，1： | 1 |
| 13 | Is subcortical disease associated with a poor response to antidepressants? Neurological,neuropsychological and neuroradiological findings in late-life depression显示文摘 | Simpson S Baldwin R C Jackson A | 1998 | Psychol Med1998，28，5： | 1 |
| 14 | Tillage effects on sediment and solute nutrient losses from a Maury silt loam soil显示文摘 | Blevins R L Frye W W Baldwin P L | 1990 | Journal of Environmental Quality1990，19，： | 1 |
| 15 | Preliminary experience with high2 volume hemofilt ration in human septic shock 显示文摘 | Bellomo R Baldwin I Cole L | 1998 | Kidney Int1998，，： | 1 |
| 16 | Global Income Divergence, Trade, and Industrialization: The Geogra phy of Growth Take-offs显示文摘 | Baldwin R E Martin P Ottaviano G I P | 2001 | Journal of Economic Growth2001，6，1： | 1 |
| 17 | Oxidation of glucose,glu- tamate, and glutamine by isolated ovine enterocytes in vitro is decreased by the presence of other metabolic fuels 显示文摘 | Oba M Baldwin R L Bequette B J | 2004 | J Ani- mal Sci2004，82，2： | 1 |
| 18 | A pilot randomized controlled comparison of extended daily dialysis with filtration and continu- ous veno-venous hemofiltration:fluid removal and hemodynamics显示文摘 | Baldwin I Bellomo R Naka T | 2007 | The International journal of artificial organs2007，30，12： | 1 |
| 19 | Communication between plant: induced resistance in wild tobacco plant following clipping of neighboring sagebrush显示文摘 | KARBAN R BALDWIN I T BAXTER K J | 2000 | Oecologia2000，125，： | 1 |
| 20 | Continuous veno-venous hemofiltration without anticoagulation in high-risk patients显示文摘 | Tan HK Baldwin I Bellomo R | 2000 | Intensive Care Med2000，26，11： | 1 |
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