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| 1 | p21-activated kinase signalling in pancreatic cancer: New insights into tumour biology and immune modulation显示文摘Pancreatic cancer is one of the most aggressive and lethal malignancies worldwide, with a very poor prognosis and a five-year survival rate less than 8%. This dismal outcome is largely due to delayed diagnosis, early distant dissemination and resistance to conventional chemotherapies. Kras mutation is a well-defined hallmark of pancreatic cancer, with over 95% of cases harbouring Kras mutations that give rise to constitutively active forms of Kras. As important down-stream effectors of Kras, p21-activated kinases(PAKs) are involved in regulating cell proliferation, apoptosis, invasion/migration and chemo-resistance. Immunotherapy is now emerging as a promising treatment modality in the era of personalized anti-cancer therapeutics. In this review, basic knowledge of PAK structure and regulation is briefly summarised and the pivotal role of PAKs in Kras-driven pancreatic cancer is highlighted in terms of tumour biology and chemoresistance. Finally, the involvement of PAKs in immune modulation in the tumour microenvironment is discussed and the potential advantages of targeting PAKs are explored. | Kai Wang Graham S Baldwin Mehrdad Nikfarjam Hong He | 2018 | World Journal of Gastroenterology2018，24，33： | 7 |
| 2 | Aroma perception of individual volatile compounds in fresh tomatoes as affected by the medium of evaluation显示文摘 | Tandon K S Baldwin E A Shewfelt R L | 2000 | Postharv Biol Technol2000，20，： | 1 |
| 3 | Series Introduction:the Transcription Factor NF-kappa B and Human Disease显示文摘 | BALDWIN A S Jr | 2001 | J Clin Investig2001，107，： | 1 |
| 4 | Comparing seeded organic-fiber mat with direct soil seeding for warm-season turf grass establishment显示文摘 | Hensler K L Baldwin B S Goatley J M Jr | 2001 | Hort Technology2001，11，2： | 1 |
| 5 | Phylogenetic utility of the external transcribed spacer (ETS) of 18S-26S rDNA: congruence of ETS and ITS trees of Calycadenia (Compositae) 显示文摘 | Baldwin B G Markos S | 1998 | Mol Phylogen Evol1998，10，3： | 1 |
| 6 | Information - seeking behavior of securities analysts individual and institutional influences, information sources and channels, and outcomes 显示文摘 | Baldwin N S Rice E R | 1997 | Journal of the American Society for Information Science1997，48，8： | 1 |
| 7 | Hyperurlcemia as a media- tor of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome 显示文摘 | Baldwin W McRae S Marek G | 2011 | Diabetes2011，60，4： | 1 |
| 8 | Sublethal effects of copper on coho salmon : impacts on nonoverlapping receptor pathways in the peripheral olfactory nervous system显示文摘 | BALDWIN D H SANDAHL J F LABENIA J S | 2003 | Environ Toxicol Chem2003，22，10： | 1 |
| 9 | DNA assembly for synthetic biology: from parts to pathways and beyond 显示文摘 | Ellis T Adie T Baldwin G S | 2011 | Integrative Biology2011，3，2： | 1 |
| 10 | Is subcortical disease associated with a poor response to antidepressants? Neurological,neuropsychological and neuroradiological findings in late-life depression显示文摘 | Simpson S Baldwin R C Jackson A | 1998 | Psychol Med1998，28，5： | 1 |
| 11 | Usefull synthesis of 4-substituted indoles显示文摘 | Ponticello G S Baldwin J J | 1979 | J Org Chem1979，44，22： | 1 |
| 12 | Pharmacotherapeutic options for thetreatment of preeclampsia显示文摘 | McCoy S Baldwin K | 2009 | Am J Health Syst Pharm2009，66，4： | 1 |
| 13 | Stability Evaluation of High Initial Response Excitation of Turbo-generator 显示文摘 | Hurley J D Baldwin M S | 1982 | IEEE Trans1982，11，： | 1 |
| 14 | Regulation of midgut growth,development,and metamorphosis显示文摘 | Hakim R S Baldwin K Smagghe G | 2010 | Annual Review of Entomology2010，55，1： | 1 |
| 15 | In vivo optical coherence tomography imaging of preinvasive bronchial lesions 显示文摘 | Lain S Standish B Baldwin C | 2008 | Clin Cancer Res2008，14，7： | 1 |
| 16 | Reactive-power compensation for voltage control at resistance welders显示文摘 | BALDWIN T L HOGANS T JR HENRY S D | 2005 | IEEE Transactions on Industry Applications2005，41，6： | 1 |
| 17 | Scapula fractures : a marker for concomitant injury? A retrospective review of data in the National Trauma Database 显示文摘 | Baldwin KD Ohman-Strickland P Mehta S | 2008 | J Trauma2008，65，2： | 1 |
| 18 | Computer simulation of semisynchronous start of hydroelectricpumped storage units显示文摘 | Gonzalez A Baldwin M S Kilgore L A | 1983 | IEEE Transactions on Power Apparatus and Systems1983，102，： | 1 |
| 19 | Mathematical modeling of the zinc pressure leach process显示文摘 | BALDWIN S A DEMOPOULOS G P PARANGELAKIS V G | 1995 | Metallurgical and Materials Transactions B1995，26，： | 1 |
| 20 | The transcription factor NF-kB and human disease 显示文摘 | Albert S Baldwin J | 2001 | J Clin Invest2001，107，1： | 1 |
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