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| 1 | Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates显示文摘Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)pandemic.Plant-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against influenza.Here,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)1018.Although a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted CoVLP.Fifteen micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T cells.Animals were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of SARS-CoV-2.Lower viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with AS03.No clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated animals.The CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials. | Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward | 2022 | Cellular & Molecular Immunology2022，19，2： | 2 |
| 2 | Prognostic value of ischaemia-medified albumin in patients with non-ST-segment elevation acute coronary syndromes显示文摘 | BALI L CUISSET T GIORGI R | 2008 | Arch Cardiovasc Dis2008，101，10： | 1 |
| 3 | Workflow management systems: The healthcare technology of the future annual 显示文摘 | Dwivedi A Bali R K James A E | 2001 | Reports of the Research Reactor Institute2001，，4： | 1 |
| 4 | Maxing out: stocks as lotteries and the cross - section of expected returns 显示文摘 | Bali T G Cakici N Whitelaw R F | 2011 | Journal of Financial Economics2011，99，2： | 1 |
| 5 | Bioavailability and toxicity of antimony 显示文摘 | Shtangeeva I Bali R Harris A | 2011 | Journal of Geochemical Exploration2011，110，1： | 1 |
| 6 | Estimating evaporation from bare soil using soil moisture data 显示文摘 | Ventura F Snyder R L Bali K M | 2006 | Journal of Irrigation and Drainage Engineering2006，132，2： | 1 |
| 7 | Maxing out:Stocks as lotteries and the cross-section of expected returns 显示文摘 | Bali T G Cakici N Whitelaw R F | 2011 | Journal of Financial Economics2011，99，2： | 1 |
| 8 | Prevalence of diabetes mellitus and hypertension among Indian glaucoma patients and evaluation of systemic therapy显示文摘 | Dave A Bali SJ Sharrna R | 2013 | lnt Ophthalmol2013，33，5： | 1 |
| 9 | Novel Microbially Triggered Colon Specifi c Delivery System of 5-Fluorouracil:Statistical Optimization,in Vitro,in Vivo,Cytotoxic and Stability Assessment显示文摘 | Dev R K Bali V Pathak K | 2011 | Int J Pharm2011，411，12： | 1 |
| 10 | Interventions to reduce HIV transmission related to injeoting drug use in prison显示文摘 | Jurgens R Bali A Verster A | 2009 | Lancet Infect Dis2009，9，1： | 1 |
| 11 | Oral submucous fibrosis: A review article on etiopathogenesis显示文摘 | Tak J Gupta N Bali R | 2014 | Kathmandu Uni versity Medical Journal2014，12，5： | 1 |
| 12 | Prognostic value of is- chemia modified albumin in patients with non-ST-segment el- evation acute coronary syndromes 显示文摘 | BALI L CUISSET T GIORGI R | 2008 | Arch Cardiovasc Dis2008，101，10： | 1 |
| 13 | Maxing out:Stocks as Lotteries and the Cross-Section of Expected Returns显示文摘 | BALI T G CAKICI N WHITELAW R F | 2011 | Journal of Financial Economics2011，99，2： | 1 |
| 14 | Coronary wall character- istics after myocardial infarction without significant coro- nary angiographic lesion:an intravascular ultrasound study显示文摘 | Poyet R Cuisset T Bali L et a/ | 2010 | Acta Cardiol2010，65，6： | 1 |
| 15 | The Intertemporal Capital Asset Pricing Model with Dynamic Conditional Correlations 显示文摘 | Bali T G R F Engle | 2010 | Joumal of Monetary Economics2010，57，4： | 1 |
| 16 | Activity of suberoylanilide hydroxamic acid against human breast cancer cells with amplification of her-2显示文摘 | Bali P Pranpat M Swaby R | 2005 | Clin Cancer Res2005，11，17： | 1 |
| 17 | Novel microbially triggered colon specific delivery system of 5-fluorouracil : statistical optimization, in vitro, in vi- vo, cytotoxic and stability assessment 显示文摘 | Dev R K Bali V Pathak K | 2011 | Int J Pharm2011，411，12： | 1 |
| 18 | Loading red blood cells with trehalose: a step towards biostabilization显示文摘 | Satpathy GR Torok Z Bali R | 2004 | Cryobiology2004，49，2： | 1 |
| 19 | Novel microbially triggered colon specific delivery system of 5 fluorouracil: Statistical optimization, in vitro, in vivo, eytotoxie and stability assessment 显示文摘 | Dev R Kumar Bali V | 2011 | International Journal of Pharmaceutics2011，411，12： | 1 |
| 20 | Noncoding RNAs; key molecules inunderstanding and treating pain 显示文摘 | BALI K K KUNER R | 2014 | Trends Mol Med2014，20，8： | 1 |
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