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| 1 | Alcohol dehydrogenase: A potential new marker for diagnosis of intestinal ischemia using rat as a model显示文摘AIM: Intestinal ischemia (Ii) is an abdominal emergency due to blockade of the superior mesenteric artery resulting in 60-100% mortality if diagnosed late. Changes in several biochemical parameters such as D (-)-lactate, Creatinine kinase isoenzymes and lactate dehydrogenase suggested for early diagnosis, lack specificity and sensitivity. Therefore a biochemical parameter with greater sensitivity needs to be identified.METHODS: Wistar male rats were randomly assigned into two groups; control sham operated (n = 24) and ischemic test (n = 24) group. Superior mesenteric arterial occlusion was performed in the ischemic test group for 1 h. Alcohol dehydrogenase (ADH) was estimated in blood from portal vein, right ventricle of heart, dorsal aorta (DA) and inferior vena cava (IVC). The Serum glutamic acid pyruvate transaminase (SGPT) was also estimated in blood from portal vein and right ventricle of heart.RESULTS: A significant increase (P<0.001) in the levels of ADH in both portal blood as well as heart blood of the test group (232.72±99.45 EU and 250.85±95.14 EU, respectively)as compared to the control group (46.39±21.69 EU and 65.38±30.55 EU, respectively) were observed. Similarly,increased levels of ADH were observed in blood samples withdrawn from DA and IVC in test animals (319.52±80.14EU and 363.90±120.68 EU, respectively) as compared to the control group (67.68±63.22 EU and 72.50±58.45 EU,respectively). However, in test animals there was significant increase in SGPT in portal blood (P = 0.054) without much increase in heart blood.CONCLUSION: Significant increase in the levels of ADH in portal and heart blood within 1 h of SMA occlusion without increase in SGPT in heart blood, suggests that the origin of ADH is from ischemic intestine and not from liver. Similarly, raised ADH levels were found in DA and IVC as well. IVC blood does represent peripheral blood sample. A raised level of ADH in test animals confirms it to be a potential marker in the early diagnosis of Ii. | Upendra R Gumaste Mukund M Joshi Devendra T Mourya Pradip V Barde Ghanshyam K Shrivastav Vikram S Ghole | 2005 | World Journal of Gastroenterology2005，11，6： | 9 |
| 2 | Lipoprotein (a) as a predictor of coronary heart disease: the PRIME Study显示文摘 | LUC G BARD J M ARVEILER D | 2001 | Atherosclerosis2001，163，2： | 2 |
| 3 | Hydrogen peroxide pro- duction in the oxygen reduction reaction at different eleetrocatalysts as quantified by scanning electrochemical microscopy 显示文摘 | SANCHEZ-SANCHEZ C M BARD A J | 2009 | Anal Chem2009，81，19： | 1 |
| 4 | ELectrochemical in-vestigation of the energetics of particulate titanium dioxide photocatalysts: the methyl viologen-acetate system 显示文摘 | Ward M D White J R Bard A J | 1983 | Journal of American Chemical Society1983，105，： | 1 |
| 5 | Plasma cystatipment of cornary heart disease:The PRIME Study显示文摘 | Luc G Bard J M Lesuer C | | 0，，2： | 1 |
| 6 | IntCal09 and Marine09 radiocarbon age calibration cmwes, 0-50,000 years cal BP显示文摘 | REIMER P J BAILLIE M G L BARD E BAYLISS A BECK J W BLACKWELL P G | 2009 | Radiocarbon2009，51，4： | 1 |
| 7 | Quality of life research in oncology-past achievements and future priorities显示文摘 | Aronson NK Meyerowitz BE Bard M | 1991 | Cancer1991，67，3： | 1 |
| 8 | Marine04 marine radio-carbon age calibration, 26~0ka BP显示文摘 | Hughen K A Bailtie M G L Bard E | 2004 | Radiocarbon2004，46，： | 1 |
| 9 | C-reactive protein, interleukin-6 and fibrinogen as predictors of coronary heart disease:the PRIME study 显示文摘 | Luc G Bard J M Juhan-Vague I | 2003 | Arterioscler Thromb Vasc Biol2003，23，7： | 1 |
| 10 | Intcal04 terrestrial radiocarbon age calibration, 0 -26 cal kyr BP 显示文摘 | Reimer P Baillie M G L Bard E | 2004 | Radiocarbon2004，46，3： | 1 |
| 11 | Community based innovation: How to integrate members of virtual communities into new product development 显示文摘 | Fuller J Bard M Ernst H | 2006 | Electron Commerce Res2006，6，1： | 1 |
| 12 | A GRASP for aircraft routing in response to groundings and delays显示文摘 | Arguello M F Bard J F Yu G | 1997 | Journal of Combinatorial Optimization1997，5，： | 1 |
| 13 | Do Servant-leaders Help Satisfy Follower Needs? An Organizational Justice Perspective 显示文摘 | Mayer D M Bardes M Piccolo R F | 2008 | European Journal of Work and Organizational Psychology2008，17，2： | 1 |
| 14 | A grasp for aircraft routing in response to groundings and delay显示文摘 | Arguello M Bard J F Yu G | 1997 | Journal of Combinatorial Optimization1997，1，3： | 1 |
| 15 | INTCAL98 radiocarbon age calibration,24000~0 cal BP显示文摘 | Stuiver M Reimer P J Bard E | 1998 | Radiocarbon1998，40，： | 1 |
| 16 | Intcal09and Ma-rine09radiocarbon age calibration curves,0 50000years calBP显示文摘 | Reimer P J Baillie M G L Bard E | 2009 | Radiocarbon2009，51，4： | 1 |
| 17 | Artificial Photosynthesis:Solar Split- ting of Water to Hydrogen and Oxygen 显示文摘 | BARD A J FOX M A | 1995 | Accounts of Chemical Research1995，28，： | 1 |
| 18 | Quality of life research in oncology:past achievements and future priorities显示文摘 | Aaronson NK Meyerowitz BE Bard M | 1991 | Cancer1991，67，： | 1 |
| 19 | An ontology for cell types显示文摘 | Bard J Rhee SY Ashburner M | 2005 | Genome Biol(S1465-6906)2005，6，2： | 1 |
| 20 | Analysis of visual search activity during sport problem situations显示文摘 | BARD C FLEURY M | 1976 | J Human Movem Stud1976，3，： | 1 |
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