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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | The mycobiota of the weed Mikania micrantha in southern Brazil with particular reference to fungal pathogens for biological control显示文摘 | Barreto R W Evans H C | 1995 | Mycol Res1995，，3： | 1 |
| 3 | Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus显示文摘 | Barreto M Santos E Ferreira R | 2004 | Eur J Hum Genet2004，12，8： | 1 |
| 4 | Nimbya alter- nantherae a potential biocontrol agent for alligatorweed, Al- ternanthera philoxeroides显示文摘 | Pomella A W V Barreto R W Charudattan R | 2007 | Bio Control2007，52，2： | 1 |
| 5 | Optimized methodology for the simultaneous extraction of glucosinolates, phenolic compounds and antioxidant capacity fi'om maca (Lepidium meyenii) 显示文摘 | Campos D Chirinos R Barreto O | 2013 | Industrial Crops and Products2013，49，： | 1 |
| 6 | Region based super resolution for compression 显示文摘 | BARRETO D ALVAREZ L D MOLINA R KATSAGGELOS A K | 2007 | Muhidimen- sional Systems and Signal Processing2007，18，2： | 1 |
| 7 | A liquid-liquid extraction procedure followed by a low temperature purifi- cation step for the analysis of macrocyclic lactones in milk by liquid chromatography-tandem mass spectrometry and fluorescence detection显示文摘 | Sameness G Barreto F Hoff R B | 2011 | Anal Chim Acta2011，705，12： | 1 |
| 8 | A new scoring system forgallbladder cancer ( aiding treatment algorithm) : an analysis of335 patients 显示文摘 | Shukla PJ Neve R Barreto SG | 2008 | Ann Surg Oncol2008，15，11： | 1 |
| 9 | Environmental blue light prewnts stress in the fish Nile tilapia显示文摘 | Volpato G I Barreto R E | 2001 | Brazilian Journal of Me:lical and Biological Research2001，34，8： | 1 |
| 10 | Experimental acute alcohol pancreatitis-related liver damage and endotoxemia:synbiotics but not metronidazole have a protective effectt显示文摘 | Marotta F Barreto R Wu CC | 2005 | Chin J Dig Dis2005，6，4： | 1 |
| 11 | Biological Control of Neotropical Aquatic Weeds with Fungi显示文摘 | BARRETO R R CHARUDATTAN A P HANADA R | 2000 | Crop Protection2000，19，： | 1 |
| 12 | K/DOQI- recommended intact PTH levels do not prevent low-turnover bone disease in hemodialysis patients 显示文摘 | Barreto F C Barreto D V MoysOs R M | 2008 | Kidney Int2008，73，6： | 1 |
| 13 | Nimbya alternantherae and Cercospora alternantherae: two new records of fungal pathogens on Alternanthera philoxeroides (alligatorweed) in Brazil显示文摘 | BARRETO R W TORRES A N L | 1999 | Australasian Plant Pathology1999，28，2： | 1 |
| 14 | Single-blind follow-up study on the effectiveness of a symbiotic preparation in irritable bowel syndrome显示文摘 | Tsuchiya R Barreto R Okura R | 2004 | Chinese Journal of Digestive Diseases2004，5，8： | 1 |
| 15 | Photocatalytic Degradation of Methyl-tert-butyl Ether in TiO2 Slurries: A proposed Reaction Scheme 显示文摘 | Barreto R D Gray K A | 1995 | Water Res1995，29，5： | 1 |
| 16 | MS222 does not induce primary DNA damage in fish显示文摘 | BARRETO R E GONTIJO A M M C ALVES - DE - LIMA R O | 2007 | Aquac2007，15，2： | 1 |
| 17 | Corruption, Optimal Taxation and Growth 显示文摘 | Barreto R A Alm I | 2003 | Public Finance Review2003，31，3： | 1 |
| 18 | Environmental blue light prevents stressin the fish Nile tilapia显示文摘 | Volpato G L Barreto R E | 2001 | Brazilian Journal of Medical andBiological Research2001，34，8： | 1 |
| 19 | Monocrotaline pyrrol is cytotoxic and alters the patterns of GFAP expression on astrocyte primary cultures显示文摘 | Barreto R A Sousa C S Silva V D A | 2008 | Toxic in Vitro2008，22，： | 1 |
| 20 | Inhibitors of vascular calcification as potential therapeutic targets显示文摘 | Rezg R Barreto FC Barreto DV | 2011 | J Nephrol2011，24，4： | 1 |
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