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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | Factors related to quality of life in patients with cirrhosis and ascites: Relevance of serum sodium concentration and leg edema显示文摘 | Elsa Solà Hugh Watson Isabel Graupera Fanny Turón Rogelio Barreto Ezequiel Rodríguez Marco Pavesi Vicente Arroyo Mónica Guevara Pere Ginès | 2012 | Journal of Hepatology2012，，6： | 3 |
| 3 | Urinary neutrophil gelatinase-associated lipocalin as biomarker in the differential diagnosis of impairment of kidney function in cirrhosis显示文摘 | Claudia Fagundes Marie-No?lle Pépin Mónica Guevara Rogelio Barreto Gregori Casals Elsa Solà Gustavo Pereira Ezequiel Rodríguez Elisabet Garcia Verónica Prado Esteban Poch Wladimiro Jiménez Javier Fernández Vicente Arroyo Pere Ginès | 2012 | Journal of Hepatology2012，，2： | 2 |
| 4 | Synergistic effect of CPPU and benzyladenine on embryo rescue in six stenospermocarpic cultivars of grapevine显示文摘 | ANookaraju M S Barreto G S Karibasappa | 2007 | Vitis2007，46，4： | 1 |
| 5 | Logging damage during planned and unplanned logging operations in the eastern Amazon显示文摘 | JOHNS J S BARRETO P UHL C | 1996 | For Ecol Manage1996，89，： | 1 |
| 6 | Efficient algorithms for pairing-based cryptosystems 显示文摘 | BARRETO P S L M KIM H Y LYNN B | 2002 | Lecture Notes in Computer Science2002，2442，： | 1 |
| 7 | Synergistic effect of CPPU and benzyladenine on embryo rescue in six stenospermocarpic cultivars of grapevine显示文摘 | Nookaraju A Barreto M S Karibasappa G S | 2007 | Vitis2007，46，4： | 1 |
| 8 | Serum indoxyl sulfate isassociated with vascular disease and mortality in chronic kidneydisease patients显示文摘 | Barreto FC Barreto DV Liabeuf S | 2009 | Clin J AmSoc Nephrol2009，4，10： | 1 |
| 9 | Melt flow optimisation using turbulence inhibitors in large volume tundishes 显示文摘 | Palafox-Ramos J Barreto J de J Lopez-Ramirez S | 2001 | Ironmaking and Steelmaking2001，28，2： | 1 |
| 10 | Systematic review of diet in the pathogenesis of acute pancreatitis : a tale of too much or too little? 显示文摘 | THOMAS T MAH L BARRETO S G | 2012 | Saudi J Gastreenterol2012，18，5： | 1 |
| 11 | Toward secure public key blockwise fragile authentication watermarking显示文摘 | Barreto P S L M Kim H Y Rijmen V | 2002 | lEE Proc Vision Image Signal Processing2002，149，2： | 1 |
| 12 | Monocrotaline pyrrol is cytotoxic and alters the patterns of GFAP expression on astrocyte primary cultures显示文摘 | Barreto R A Sousa C S Silva V D A | 2008 | Toxic in Vitro2008，22，： | 1 |
| 13 | Efficient Pairing Computation on Supersingular AbeIian Varieties显示文摘 | Barreto P Galbraith S Eigeartaigh C | 2007 | Des ( odes Cryptograp2007，42，3： | 1 |
| 14 | Vitamin D affects survival independently of vascular calcification in chronic kidney disease 显示文摘 | Barreto DV Barreto FC Liabeuf S | 2009 | Clin J Am SocNephrol2009，4，： | 1 |
| 15 | Using clustering analysis in a capacitated location-routing problem 显示文摘 | Barreto S Ferreira C Paixao J | 2007 | European Journal of Operational Research2007，179，： | 1 |
| 16 | Genotoxicity and morphological changes induced by the alkaloid monocrotaline, extracted from Crotalafia retusa, in a model of glial ceils 显示文摘 | Silva-Neto J P Barreto R A Pitanga B P S | 2010 | Toxicon2010，55，： | 1 |
| 17 | Efticient pairing computation on supersingular Abelian varieties显示文摘 | Barreto P Galbraith S hEigeartaigh C 0 | 2007 | Designs Codes and Cryptography2007，42，3： | 1 |
| 18 | A nested case-control study of fatal work related injuries among Brazilian steel workers显示文摘 | Barreto S Swerdlow A | 1997 | Occup Environ Med1997，54，： | 1 |
| 19 | Using a chlorophyll meter to estimate specific leaf nitrogen of tropical maize during vegetative growth显示文摘 | Chapman S C Barreto H J | 1997 | Agron J1997，89，： | 1 |
| 20 | Endogenizing R&D and market experience in the 'bottom-up' energy-systems ERIS model显示文摘 | Barreto L Kypreos S | 2004 | Technovation2004，24，8： | 1 |
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