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| 1 | Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease显示文摘AIM: Prostaglandin G/H synthase 2 (PTGS2 or COX2) is one of the key factors in the cellular response to inflammation.PTGS2 is expressed in the affected intestinal segments of patients with inflammatory bowel diseases (IBD). In IBD patients, non-steroidal anti-inflammatory drugs, which have been shown to reduce both the production and activity of PTGS2, may activate IBD and aggravate the symptoms.We aimed at examining genetic variants of PTGS2 that may be risk factors for IBD.METHODS: We genotyped 291 individuals diagnosed with IBD and 367 controls from the Dutch population for the five most frequent polymorphisms of the PTGS2 gene.Clinical data were collected on all patients. DNA was extracted via normal laboratory methods. Genotyping was carried out using multiplex PCR followed by the Invader Assay and the 5' exonuclease assay (TaqMan). New polymorphism screening was performed by pre-screening with denaturing high-performance liquid chromatography,followed by fluorescent sequencing.RESULTS: Allele 5209G was weakly associated with Crohn's disease (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.03-2.57), and allele 8473T with ulcerative colitis (OR 1.50, 95%CI 1.00-2.27). The haplotype including both alleles showed a strong association with IBD (OR 13.15, 95%CI 3.17-116.15). This haplotype, while rare (-0.3%) in the general population, is found more frequently in patients (3.5%).CONCLUSION: Our data suggest that this haplotype of PTGS2 contributes to the susceptibility of IBD. | David G Cox J Bart A Crusius Petra HM Peeters H Bas Bueno-de-Mesquita A Salvador Pe(n|~)a Federico Canzian | 2005 | World Journal of Gastroenterology2005，11，38： | 10 |
| 2 | Prediction of delayed graft function using different scoring algorithms: A single-center experience显示文摘AIM To compare the performance of 3 published delayed graftfunction(DGF) calculators that compute the theoretical risk of DGF for each patient.METHODS This single-center,retrospective study included 247 consecutive kidney transplants from a deceased donor.These kidney transplantations were performed at our institution between January 2003 and December 2012.We compared the occurrence of observed DGF in our cohort with the predicted DGF according to three different published calculators. The accuracy of the calculators was evaluated by means of the c-index(receiver operating characteristic curve).RESULTS DGF occurred in 15.3% of the transplants under study.The c index of the Irish calculator provided an area under the curve(AUC) of 0.69 indicating an acceptable level of prediction,in contrast to the poor performance of the Jeldres nomogram(AUC = 0.54) and the Chapal nomogram(AUC = 0.51). With the Irish algorithm the predicted DGF risk and the observed DGF probabilities were close. The mean calculated DGF risk was significantly different between DGF-positive and DGF-negative subjects(P < 0.0001). However,at the level of the individual patient the calculated risk of DGF overlapped very widely with ranges from 10% to 51% for recipients with DGF and from 4% to 56% for those without DGF.The sensitivity,specificity and positive predictive value of a calculated DGF risk ≥ 30% with the Irish nomogram were 32%,91% and 38%. CONCLUSION Predictive models for DGF after kidney transplantation are performant in the population in which they were derived,but less so in external validations. | Magda Michalak Kristien Wouters Erik Fransen Rachel Hellemans Amaryllis H Van Craenenbroeck Marie M Couttenye Bart Bracke Dirk K Ysebaert Vera Hartman Kathleen De Greef Thiery Chapelle Geert Roeyen Gerda Van Beeumen Marie-Paule Emonds Daniel Abramowicz Jean-Louis Bosmans | 2017 | World Journal of Transplantation2017，7，5： | 3 |
| 3 | NIR Spectroscopy Applications for Internal and External Quality Analysis of Citrus Fruit—A Review显示文摘 | Lembe S. Magwaza Umezuruike Linus Opara Hélène Nieuwoudt Paul J. R. Cronje Wouter Saeys Bart Nicola? | 2012 | Food and Bioprocess Technology2012，，2： | 2 |
| 4 | Experimental Validation of a New Ultrasound Method for the Simultaneous Assessment of Radial and Longitudinal Myocardial Deformation Independent of Insonation Angle显示文摘 | Stian Langeland Jan D’hooge Patrick F. Wouters H Alex Leather Piet Claus Bart Bijnens George R. Sutherland | 2005 | Circulation2005，，14： | 2 |
| 5 | Treatment of organic pollutants in coke plant wastewater by the method of ultrasonic irradiation, catalytic oxidation and activated sludge显示文摘 | NING P BART H J JIANG Y J | 2005 | Separation and Purification Technology2005，41，2： | 1 |
| 6 | Falling Film Evap- oration with Polymeric Heat Transfer Surfaces 显示文摘 | Christmann Joehen B P Kritz L J Bart H J | 2011 | Desalination2011，，： | 1 |
| 7 | Therapeutic strategies in acute intracerebral hemorrhage显示文摘 | H BART B JOSHUA N GOLDSTEIN | 2012 | Neurotherapeutics2012，9，1： | 1 |
| 8 | Validation of the 4B5 rabbit monoclonal antibody in determining HER-2/neu status in breast cancer显示文摘 | van der Vegt B de Bock G H Bart J | 2009 | Mod Pathol2009，22，7： | 1 |
| 9 | Treatment of space-occupying cerebral infarction显示文摘 | Hofeijer J Bart van der worp H Jaop Kappelle L | 2003 | Crit Care Med2003，32，： | 1 |
| 10 | Kinetics of BSA release from poly(N-isopropylacrylamide) hydrogels显示文摘 | Naddaf A A Tsibranska I Bart H J | 2010 | Chemi- cal Engineering and Processing : Process Intensification2010，49，6： | 1 |
| 11 | Nur Structure de 12CaO'7A1203 显示文摘 | Bart H Scheller T | 1970 | N Ib Miner Mg1970，35，： | 1 |
| 12 | Removal of phosphorus and sulfur from yellow phosphorus off-gas by metal-modified activated carbon显示文摘 | NING Ping WANG Xiangyu Bart H J | 2011 | Journal of Cleaner Production2011，19，13： | 1 |
| 13 | Product shape selectivity dominates the Methanol-to-Olefins (MTO) reaction over H-SAPO-34 catalysts显示文摘 | Hereijgers Bart P C Bleken Francesca Nilsen Merete H | 2009 | Journal of Cataly- sis2009，264，1： | 1 |
| 14 | Treat ment of space-occupying cerebral infarction显示文摘 | Hofeijer J Bart van der Worp H Jaap Kappetle L | 2003 | Crit Care Med2003，，31： | 1 |
| 15 | Chemisorptive catalytic oxidation process for SO2 from smelting waste gases by Fe(I)显示文摘 | Bart H J Ning P Sun P S | 1996 | Separations Technology61996，6，4： | 1 |
| 16 | Quantitative assessment of P-glycoprotein function in the rat blood-brain barrier by distribution volume of verapamil measured with PET显示文摘 | Bart J WiUemsen AT Groen H J | 2003 | Neuroimage2003，20，3： | 1 |
| 17 | Which tangible and intangible asset matter for innovation speed in start-ups?显示文摘 | Ans H Bart C | 2007 | Journal of Product Innovation Management2007，24，4： | 1 |
| 18 | Active electromagnetic suspension system for improved vehicle dynamics 显示文摘 | BART L J JOHANNES J H JEROEN L G | 2010 | IEEE Transactions on Vehicular Technology2010，59，3： | 1 |
| 19 | An HIV-1 clade C DNA prime,NYVAC boost vaccine regimen induces reliable,polyfunctional,and long-lasting T cell responses显示文摘 | Harari A Bart PA St(o)hr W Tapia G Garcia M Medjitna-Rais E Burnet S Cellerai C Erlwein O Barber T Moog C Liljestrom P Wagner R Wolf H Kraehenbuhl JP Esteban M Heeney J Frachette MJ Tartaglia J McCormack S Babiker A Weber J Pantaleo G | 2008 | J Exp Med2008，205，1： | 1 |
| 20 | Extraction of zinc with long-chain beta-diketones and 4-acyl-5-pyrazolones显示文摘 | MICKLER W REICH A UHLEMANN E BART H J | 1995 | Separation Science and Technology1995，30，12： | 1 |
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