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| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | Eicosapentaenoic acid induces mRNA expression of peroxisome proliferatoractivated receptor gamma 显示文摘 | Chambrier C Bastard J P Rieusset J | 2002 | Obes Res2002，10，6： | 1 |
| 3 | Elevated levels of interleukin- 6 are reduced in serum and subcutaneous adipose tissue of obese women after weig ht loss显示文摘 | Bastard JP Jardel C Bruckert E | 2000 | J Clin Endocrinol Metab2000，85，9： | 1 |
| 4 | Hypodiploidy is a major pronostic factor in multiple myeloma显示文摘 | Smadja NV Bastard C Brigaudeau C | 2001 | Blood2001，98，： | 1 |
| 5 | Concunent activation of MYC and bcl-2 in B cell non- Hodgkin's lymphoma cell lines by translocation of both oncogenes to the same immunoglobulin heavy chain locus 显示文摘 | Dyer M J Lillington D M Bastard C | 1996 | Leukemia1996，10，7： | 1 |
| 6 | Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte:prevention by rosiglitazone显示文摘 | Lagathu C Bastard JP Auclair M | 2003 | Biochem Biophys Res Commun2003，311，2： | 1 |
| 7 | TET2 and DNMT3A mutations in human T-cell lymphoma显示文摘 | Couronn~ L Bastard C Bernard OA | 2012 | N Engl J Med2012，366，1： | 1 |
| 8 | Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte, prevention by rosiglitazone显示文摘 | Lagathu C Bastard JP Auclair M | 2003 | Biochem Biophys Res Commun2003，311，2： | 1 |
| 9 | Recent advances in the relationship between obesity, inflammation, and insulin resistance 显示文摘 | Bastard JP Maachi M Lagathu C | 2006 | Eur Cytokine Netw2006，17，1： | 1 |
| 10 | Primary plasma cell leukemia and multiple myeloma: one or two diseases according to the methodology显示文摘 | Smadja NV Bastard C Brigaudeau C | 1999 | Blood1999，94，10： | 1 |
| 11 | Evidence for a link between adipose tissue content and serum C-reactive protein concentration in obese subjects显示文摘 | Bastard PB Jardel C Delattre J | 1999 | Circulation1999，99，： | 1 |
| 12 | Secondary Philadelphia chromosome in a patient with acute lymphoblastic leukemia显示文摘 | Chen L Stamatoullas A Bastard C | 2004 | Cancer Genet Cytogenet2004，152，2： | 1 |
| 13 | Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipo- cyte: prevention by rosiglitazone显示文摘 | LAGATHU C BASTARD J P AUCLAIR M | 2003 | Biochem Biophys Res Commun2003，311，： | 1 |
| 14 | Elevated levels of interleukin-6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss显示文摘 | Bastard JP Jardel C Bruckert E | 2000 | Clin Endocrinol Metab2000，85，9： | 1 |
| 15 | Chronic interleukin-6(IL-6) treatment increased IL-6 secretion and induced insulinresistance in adipocyte : prevention by rosiglitazone 显示文摘 | Lagathu C Bastard J P Auclair M | 2003 | Biochem Biophys Res Commun2003，311，2： | 1 |
| 16 | LAZ3 rearrangements in non- hodgkin's lymphoma:correlation with histology,immunophenotype,karyotype,and clinical outcome in 217 patients显示文摘 | Bastard C Deweindt C Kerckaert JP | 1994 | Blood1994，83，： | 1 |
| 17 | Chronic interleukin-6( IL-6 ) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone 显示文摘 | Lagathu C Bastard JP Auclair M | 2003 | Biochem Biophys Res Comm2003，311，2： | 1 |
| 18 | Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese woman after weight loss显示文摘 | Bastard J Jardel C Bruckert E | 2000 | J Clin Endocrinol Metab2000，85，： | 1 |
| 19 | Eicosapentaenoicacid induces mRNA expression of peroxisome preliferator - activa- ted receptor gamma 显示文摘 | Chambrier C Bastard J P Rieusset J | 2002 | Obesity Research2002，10，6： | 1 |
| 20 | Recent advances in the relationship between obesity, inflammation, and insulin resistance显示文摘 | Bastard J P Maachi M Lagathu C | 2006 | Eur Cytokine Netw2006，17，1： | 1 |
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