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| 1 | Small intestinal bacterial overgrowth in inactive Crohn's disease:Influence of thiopurine and biological treatment显示文摘AIM:To investigate the influence of thiopurines and biological drugs on the presence of small intestinal bacterial overgrowth(SIBO) in patients with inactive Crohn's disease(CD).METHODS:This was a prospective study in patients with CD in remission and without corticosteroid treatment,included consecutively from 2004 to 2010.SIBO was investigated using the hydrogen glucose breath test.RESULTS:One hundred and seven patients with CD in remission were included.Almost 58%of patients used maintenance immunosuppressant therapy and 19.6%used biological therapy.The prevalence of SIBO was16.8%.No association was observed between SIBO and the use of thiopurine Immunosuppressant(12/62patients),administration of biological drugs(2/21 patients),or with double treatment with an anti-tumor necrosis factor drugs plus thiopurine(1/13 patients).Half of the patients had symptoms that were suggestive of SIBO,though meteorism was the only symptom that was significantly associated with the presence of SIBO on univariate analysis(P<0.05).Multivariate analysis revealed that the presence of meteorism and a fistulizing pattern were associated with the presence of SIBO(P<0.05).CONCLUSION:Immunosuppressants and/or biological drugs do not induce SIBO in inactive CD.Fistulizing disease pattern and meteorism are associated with SIBO. | Cristina Sánchez-Montes Vicente Ortiz Guillermo Bastida Ester Rodríguez María Yago Belén Beltrán Mariam Aguas Marisa Iborra Vicente Garrigues Julio Ponce Pilar Nos | 2014 | World Journal of Gastroenterology2014，20，38： | 4 |
| 2 | Adalimumab in prevention of postoperative recurrence of Crohn's disease in high-risk patients显示文摘AIM:To evaluate the effectiveness of adalimumab in preventing recurrence after intestinal resection for Crohn's disease in high-risk patients.METHODS:A multicenter,prospective,observational study was conducted from June 2009 until June 2010.We consecutively included high-risk Crohn's disease patients who had undergone an ileal/ileocolonic resection.High-risk patients were defined as two or more criteria:smokers,penetrating pattern,one or more previous surgical resections or prior extensive resection.Subcutaneous adalimumab was administered 2 wk(± 5 d) after surgery at a dose of 40 mg eow,with an initial induction dose of 160/80 mg at weeks 0 and 2.Demographic data,previous and concomitant treatments(antibiotics,5-aminosalicylates,corticosteroids,immunomodulators or biologic therapies),smoking status at the time of diagnosis and after the index operation and number of previous resections(type and reason for surgery) were all recorded.Biological status was assessed with C-reactive protein,erythrocyte sedimentation rate and fecal calprotectin.One year(± 3 mo) after surgery,an ileocolonoscopy and/or magnetic resonance enterography was performed.Endoscopic recurrence was defined as Rutgeerts score ≥ i2.Morphological recurrence was based on magnetic resonance(MR) score ≥ MR1.RESULTS:Twenty-nine patients(55.2% males,48.3% smokers at diagnosis and 13.8% after the index operation),mean age 42.3 years and mean duration of the disease 13.8 years were included in the study.A mean of 1.76(range:1-4) resections previous to adalimumab administration and in 37.9% was considered extensive resection.51.7% had previously received infliximab.Immunomodulators were given concomitantly to 17.2% of patients.Four of the 29(13.7%) developed clinical recurrence,6/29(20.7%) endoscopic recurrence and 7/19(36.8%) morphological recurrence after 1-year.All patients with clinical recurrence showed endoscopic and morphological recurrence.A high degree of concordance was found between clinical-endoscopic recurrence(k = 0.76,P < 0.001) and clinical-morphological recurrence(k = 0.63,P = 0.003).Correlation between endoscopic and radiological findings was good(comparing the 5-point Rutgeerts score with the 4-point MR score,a score of i4 was classified as MR3,i3 as MR2,and i2-i1 as MR1)(P < 0.001,r s = 0.825).During follow-up,five(17.2%) patients needed adalimumab dose intensification(40 mg/wk);Mean time to intensification after the introduction of adalimumab treatment was 8 mo(range:5 to 11 mo).In three cases(10.3%),a biological change was needed due to a worsening of the disease after the dose intensification to 40 mg/wk.One patient suffered an adverse event.CONCLUSION:Adalimumab seems to be effective and safe in preventing postoperative recurrence in a selected group of patients who had undergone an intestinal resection for their CD. | Mariam Aguas Guillermo Bastida Elena Cerrillo Belén Beltrán Marisa Iborra Cristina Sánchez-Montes Fernando Muoz Jesús Barrio Sabino Riestra Pilar Nos | 2012 | World Journal of Gastroenterology2012，18，32： | 3 |
| 3 | The Protective Action of Two Vapor-Phase Inhibitors on the Corrosion of Mild Steel显示文摘 | Bastidas J M Mora E M Feliu S | 1990 | Werkstoffe Korrosion1990，41，9： | 1 |
| 4 | Study of the electrochemical noise generated by the mild steel/zinc - rich paint/NaCl solution system 显示文摘 | Bastidas J M Feliu S Jr Morcillo M | 1990 | Progress in Organic Coatings1990，18，3： | 1 |
| 5 | Power-assisted suction lipectomy of fasciocutaneous flaps in the extremities显示文摘 | Reuben CM Bastidas N Sharma S | 2010 | Ann Plast Surg2010，65，1： | 1 |
| 6 | Male and female cord blood lipoprotein profile differences throughout the term-period显示文摘 | Bastida S Sanchez-Muniz FJ Cuesta C | 1997 | J Perinat Med1997，25，： | 1 |
| 7 | Fasting status and thermally oxidized sunflower oil ingestion affect the in-testinal antioxidant enzyme activity and gene expression of male Wistar rats显示文摘 | Olivero David R Bastida S Schultz A | | 0，，04： | 1 |
| 8 | Parameter Estimation of A Land Surface Scheme Using Multicriteria Methods显示文摘 | Gupta H V Bastidas L A Sorooshian S | 1999 | Journal of Geophysical Research1999，104，16： | 1 |
| 9 | A contribution to the study on electropolishing of mild steel and aluminium using alternating current 显示文摘 | LABARGA J E BASTIDAS J M FELIU S | 1991 | Electroehimica Acta1991，36，1： | 1 |
| 10 | Effects of APOA5 S19W polymorphism on growth,insulin sensitivity and li-poproteins in normoweight neonates显示文摘 | Gesteiro E Bastida S Vázquez-Velasco M | | 0，，12： | 1 |
| 11 | Synthesis of the aminocyclopentitol moieties of the hopanoids of Zy- momonas mobilis and Anacystis Montana 显示文摘 | Chiara J L de Gracia I S Bastida A | 2003 | Chem Comm2003，15，： | 1 |
| 12 | Composition and antioxidant capacity of low-salt meat emulsion model systems containing edible seaweeds显示文摘 | Lopez-Lopez I Bastida S Ruiz-Capillas C | 2009 | Meat Science2009，83，： | 1 |
| 13 | Small Supplements of N-3 Fatty Acids Change Serum Low Density Lipoprotein Composition by Decreasing Phospholipid and Apolipoprotein B Concentrations in Young Adult Women 显示文摘 | Sanchez-Muniz F J Bastida S Viejo J M | 1999 | Eur J Nutr1999，38，： | 1 |
| 14 | The effect of consuming meat enriched in walnut paste on platelet aggregation and thrombogenesis varies in volunteers with different apolipoprotein A4 genotype显示文摘 | Canales A Benedi J Bastida S | 2010 | Nutr Hosp2010，25，5： | 1 |
| 15 | Cyclic fatty acid monomer formation in domestic frying of frozen foods in sunflower oil and high oleic acid sunflower oil without oil replenishment 显示文摘 | Romero A Bastida S Sanchez- Muniz F J | 2006 | Food and chemical toxicology2006，44，10： | 1 |
| 16 | Anti-human im- munodeficiency virus type 1 (HIV-1)activity of lectins from Narcissus species 显示文摘 | Lopez S Armand-Ugon M Bastida J | 2003 | Planta Medica2003，69，2： | 1 |
| 17 | Galanthamine production in 'shoot-clump' cultures of Narcissus confusus in liquid-shake medium显示文摘 | Bergonon S Codina C Bastida J | 1996 | Plant Cell Tissue and Organ Culture1996，45，3： | 1 |
| 18 | Biochar influences the microbial community structure during manure composting with agricultural wastes显示文摘 | Keiji Jindo Miguel A. Sánchez-Monedero Teresa Hernández Carlos García Toru Furukawa Kazuhiro Matsumoto Tomonori Sonoki Felipe Bastida | 2011 | Science of the Total Environment2011，，： | 1 |
| 19 | Mechanism of cathodic protection of zinc-rich paints by electrochemical impedance spectroscopy--Ⅰ: Galvanic stage 显示文摘 | FELIU S BARAJAS R BASTIDAS J M | 1989 | Journal of Coatings Technology1989，61，775： | 1 |
| 20 | Anti-human immunodeficiency virus type 1(HIV-1)activity of lectins from Narcissus species显示文摘 | Lopez S Armand-Ugon M Bastida J | 2003 | Planta Med2003，69，2： | 1 |
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