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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Independent component analysis of electroencephalographic data 显示文摘 | Makeig S Bell A J Sejnowski T J | 1996 | Advances in Neural Information Processing Systems1996，8，： | 1 |
| 3 | Synthesis and characterization of polypyrrole-magnetite-silica particles显示文摘 | Btterworth M D Bell S A Armes S P Simpson A W | 1996 | J Colloid Interf Sci1996，183，： | 1 |
| 4 | Analysis of fMRI data by blind separation into independent spatial components 显示文摘 | Mckeown M J Makelg S Brown G G Jung T P Kinderman S S Bell A J and Sejnowski T J | 1998 | Human Brain Mapping1998，6，： | 1 |
| 5 | A high-order projection method for tracking fluid interface in variable density incompressible flows显示文摘 | Puckett E G Almgren A S Bell J B | 1997 | Compute Phys1997，130，： | 1 |
| 6 | Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins显示文摘 | Jantzen H M Admon A Bell S P | 1990 | Nature1990，344，： | 1 |
| 7 | Delta opioid receptor stimulation mimics ischemic preconditioning in human heart muscle显示文摘 | BELL S P SACK M N PATEL A | 2000 | J Am Coll Cardiol2000，36，7： | 1 |
| 8 | Aquaporin water channels AQP1 and AQP3, are expressed in equine ar- ticular chondrocytes显示文摘 | MOBASHERI A TRUJILLO E BELL S | 2004 | Vet J2004，168，2： | 1 |
| 9 | Ability Based Pairing Strategies in The Team-Based Training of Complex Skill:Does The Intelligence of Your Training Partner Matter?显示文摘 | DAY E A ARTHUR W BELL S T | 2005 | Intelligence2005，33，1： | 1 |
| 10 | Diuretics:1,2,4-Benzothiadiazine-1,1-Dioxides显示文摘 | NoveUo F C Bell S C Abram s E L A | 1960 | J Org Chem1960，25，6： | 1 |
| 11 | A synthesis of 2- and 4 (5)- (2-pyridinyl) imidazoles by palladium-catalysed cross-coupling reactions 显示文摘 | Bell A S Roberts D A Ruddock K S | 1988 | Tetrahedron Lett1988，29，： | 1 |
| 12 | Drinking pat- tern, abstention and problem drinking as risk fac-tors for depressive symptoms: evidence from three urban eastern European populations显示文摘 | Bell S Britton A Kubinova R | 2014 | PLoS One2014，9，04： | 1 |
| 13 | Increased brain edema in aqp4-null mice in an experimental model of subarachnoid hemorrhage显示文摘 | TAIT M J SAADOUN S BELL B A etal | 2010 | Neuroscience2010，167，1： | 1 |
| 14 | The dynamic rheological properties of glutens and gluten subfranctions fome wheat of good and poor bread-making quality 显示文摘 | Khatkar B S Bell A E Schofield J D | 1995 | Journal of Ce- real Science1995，22，： | 1 |
| 15 | Development and application of molecular marker linkage maps in woody fruit crops显示文摘 | N F Weeden M Hemmatt D M Lawson M Lodhi R L Bell A G Manganaris B I Reischs S K Brown G N Ye | 1994 | Euphytica1994，77，12： | 1 |
| 16 | Ab Initio and Density Functional Study of the Resonance Raman Spectra of Methyl Red,Ethyl Red and Their Protonated Derivatives显示文摘 | BISSET A DINES T J | 1998 | Journal of Raman Spectroscopy1998，29，： | 1 |
| 17 | The phase II urokinase-streptokinase pulmonary embolism trial: a national cooperative study显示文摘 | Sasahra A A Bell W R Simon T L Stengle J M Sherry S | 1975 | Thromb Diath Haemorrh1975，33，： | 1 |
| 18 | Delta opioid receptor stimulation mimics ischemic preconditioning in human heart muscle 显示文摘 | Bell S P Sack M N Patel A | 2000 | J Am Coil Cardiol2000，36，7： | 1 |
| 19 | The optimisation of traffic count locations in road networks 显示文摘 | EHLERT A BELL M G H GROSSO S | 2006 | Transportation Research Part B2006，40，6： | 1 |
| 20 | Air temperature and winter mortality: implications for the persistence of the invasive mussel, Perna viridis in the intertidal zone of the south- eastern United States显示文摘 | Firth L B Knights A M Bell S S | 2011 | J Experim Mar Biol Ecol2011，400，25： | 1 |
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