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| 1 | Methionine adenosyltransferases in liver cancer显示文摘Methionine adenosyltransferases(MATs)are essential enzymes for life as they produce S-adenosylmethionine(SAMe),the biological methyl donor required for a plethora of reactions within the cell.Mammalian systems express two genes,MAT1A and MAT2A,which encode for MATα1 and MATα2,the catalytic subunits of the MAT isoenzymes,respectively.A third gene MAT2B,encodes a regulatory subunit known as MATβwhich controls the activity of MATα2.MAT1A,which is mainly expressed in hepatocytes,maintains the differentiated state of these cells,whilst MAT2A and MAT2B are expressed in extrahepatic tissues as well as non-parenchymal cells of the liver(e.g.,hepatic stellate and Kupffer cells).The biosynthesis of SAMe is impaired in patients with chronic liver disease and liver cancer due to decreased expression and inactivation of MATα1.A switch from MAT1A to MAT2A/MAT2B occurs in multiple liver diseases and during liver growth and dedifferentiation,but this change in the expression pattern of MATs results in reduced hepatic SAMe level.Decades of study have utilized the Mat1a-knockout(KO)mouse that spontaneously develops non-alcoholic steatohepatitis(NASH)and hepatocellular carcinoma(HCC)to elucidate a variety of mechanisms by which MAT proteins dysregulation contributes to liver carcinogenesis.An increasing volume of work indicates that MATs have SAMe-independent functions,distinct interactomes and multiple subcellular localizations.Here we aim to provide an overview of MAT biology including genes,isoenzymes and their regulation to provide the context for understanding consequences of their dysregulation.We will highlight recent breakthroughs in the field and underscore the importance of MAT’s in liver tumorigenesis as well as their potential as targets for cancer therapy. | Ben Murray Lucia Barbier-Torres Wei Fan JoséM Mato Shelly C Lu | 2019 | World Journal of Gastroenterology2019，25，31： | 10 |
| 2 | Effect of dietary phospholipid levels on performance, enzyme activities and fatty acid composition of pikeperch (Sander lucioperca) larvae显示文摘 | Hamza M Mhetli I Ben K C | 2008 | Aquaculture2008，275，： | 1 |
| 3 | A large-scale Web-based virtual oscilloscope laboratory experiment显示文摘 | Ben C C Ko Chen M | 2000 | Engineering Science and Education Joumal2000，，4： | 1 |
| 4 | (A) 显示文摘 | Cao Huai xin Xu zong ben Zhang Jian hua Matrix-trace on C^*- algebra M | 2002 | Linear Algebra and its Applications2002，，345： | 1 |
| 5 | Increased antifungal activity of Tfichoderma harzianum transformants that overexpress a 33-kDa chitinase显示文摘 | Limon M C Pintor-Toro J A Benítez T | 1999 | Phytopathol1999，89，： | 1 |
| 6 | Recent Humanto-Poultry Host Jump,Adaptation,and Pandemic Spread of Staphylococcus Aureus显示文摘 | LOWDER B V GUINANE C M BEN ZAKOUR NL | 2009 | Proc Natl Acad Sci U S A2009，106，19： | 1 |
| 7 | Isolation and identifica- tion of mycoparasitic isolates of Tdchoderma aspere/um with potential for suppression of black pod disease of cacao in Cameroon显示文摘 | Tondje P R Roberts D P Ben M C | 2007 | Bio- logical Control2007，43，2： | 1 |
| 8 | New insights to the MLL recombinome of acute leukemias显示文摘 | Meyer C Kowarz E Hofmann J Renneville A Zuna J Trka J Ben Abdelali R Macintyre E De Braekeleer E De Braekeleer M Delabesse E de Oliveira MP Cavé H Clappier E van Dongen JJ Balgobind BV van den Heuvel-Eibrink MM Beverloo HB Panzer-Grümayer R Teigler-Schleg | | 0，，08： | 1 |
| 9 | Remote-con- trolled magnetic pulmonary vein isolation using a new three-dimensional non-fluoroscopic navigation system: a single-centre prospective study 显示文摘 | Da Costa A Ben H'dech M Romeyer-Bouchard C | 2013 | Arch Cardiovasc Dis2013，106，89： | 1 |
| 10 | The effect of dehydration and ion stress on carbon dioxide fixation in drought-tolerant phototrophic micro-organisms 显示文摘 | Ben De W Hans C P W Luuc R M | 1990 | FEMS Microhiol Lett1990，74，1： | 1 |
| 11 | Spatial and temporal variations of actual soil water repellency and their influence on surface runoff显示文摘 | Lemmnitz C Kuhnert M Bens O | 2008 | Hydrological Processes2008，22，12： | 1 |
| 12 | Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis显示文摘 | Maarten Boers Arco C Verhoeven Harry M Markusse Mart AFJ van de Laar Rene Westhovens J Christiaan van Denderen Derkjen van Zeben Ben AC Dijkmans Andre J Peeters Piet Jacobs Hans R van den Brink Hubert JA Schouten Désirée MFM van der Heijde Annelies Boonen | 1997 | The Lancet1997，，9074： | 1 |
| 13 | Influence of de electric current on the hardness of thermally aged Cu-Cr-Zr alloy 显示文摘 | Wang Z J Zhong Y B Cao G H Wang C Wang J Ren W L Lei Z S Ben Z M | 2009 | Journal of Alloys and Compounds2009，479，： | 1 |
| 14 | Insulin Resistance, the Metabolic Syndrome, and Nonalcoholic Fatty Liver Disease显示文摘 | F Angelico M Del Ben R Conti S Francioso K Feole S Fiorello M G. Cavallo B Zalunardo F Lirussi C Alessandri F Violi | 2005 | The Journal of Clinical Endocrinology & Metabolism2005，，3： | 1 |
| 15 | Theoretical analysis and experimental characterization of the dummygated VDMOSFET显示文摘 | XU S M BEN C H LIANG Y C | | 0，，09： | 1 |
| 16 | Atypical CT and MRI aspects of an epidermoid cyst 显示文摘 | Ben Hamouda M Drissi C Sebai R | 2007 | J Neuroradiol2007，34，2： | 1 |
| 17 | A large scale web - based virtual oscilloscope laboratory experiment 显示文摘 | C C KO Ben M Chen S H Chen | 2000 | Engineering Science and Education Journal2000，06，： | 1 |
| 18 | Pyrolysis of Timahdit, Morocco, oil shales under microwave field显示文摘 | Ben C M Lallemant M Mokhlisse A | 2000 | Fuel2000，73，10： | 1 |
| 19 | Simultaneous Determi- nation of Sulfonamides, Tetracyclines and Tiamulin in Swine Wastewater by Solid-Phase Extraction and Liquid Chromatography- Mass Spectrometry显示文摘 | BEN W W QIANG Z M ADAMS C | 2008 | Journal of Chromatography A2008，1202，2： | 1 |
| 20 | Immunologicial disorders in C virus chronic activehepatitis,a prospective case control study显示文摘 | PawIotsky J M Ben Yahia M Andre C | 1994 | Ahaepatology1994，19，4： | 1 |
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