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| 1 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 2 | Fiber-bundle coupled diode end-pumped Nd:YAG laser显示文摘 | Berger J Welch D F Streifer W | 1988 | Opt Lett1988，13，4： | 2 |
| 3 | Shadowgraph- ic and interferometric investigations on Nd:YAG laser-induced vapor/ plasma plumes for different processing wavelengths 显示文摘 | BREITLING D SCHITTENHELM H BERGER P | 1999 | Appl Phys1999，69，1： | 1 |
| 4 | Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-I integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals显示文摘 | Dejesus E Berger D Markowitz M | 2006 | J Acquir Immune Defic Syndr2006，43，1： | 1 |
| 5 | Acetylation of histones and transcription-related factors 显示文摘 | Sterner D E Berger S L | 2000 | Microbiol Mol Biol Rev2000，64，2： | 1 |
| 6 | Predictive value of S lOObeta and neuron specific enolase serum levels for adverse neurologic outcome after cardiac surgery显示文摘 | Georgiadis D Berger A Kowatschev E | 2000 | J Thorac Cardiovasc Surg2000，119，1： | 1 |
| 7 | Parity effects in small superconducting particles 显示文摘 | Berger S D Halperin B I | 1998 | Phys Rev B1998，58，： | 1 |
| 8 | Flows in stenotic vessels 显示文摘 | Berger S A Jou L D | 2000 | Annual Review of Fluid Mechanics2000，32，： | 1 |
| 9 | Mask fabrication for projection electron- beam lithography incor-porating the SCALPEL technique显示文摘 | J A Liddle H A Huggins S D Berger | 1991 | J Vac Sci Technol1991，9，6： | 1 |
| 10 | The genome sequence of the probiotic intestinal bacterium Lactobacillus johnsonii NCC 533显示文摘 | PRIDMORE R D BERGER B DESIERE F | 2004 | Proc Natl Acad Sci USA2004，，8： | 1 |
| 11 | Less is more,regularly:metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice显示文摘 | Hanahan D Bergers G Bergsland E | 2000 | J Clin Investig2000，105，： | 1 |
| 12 | Authigenic kaolin and illitic minerals during burial diagenesis of sandstones : a review 显示文摘 | Lanson B Beaufort D Berger G | 2002 | Clay Minerals2002，37，： | 1 |
| 13 | Chemical concentration measurement in blood serum and urine samples u- sing liquid-core optical fiber Raman spectroscopy 显示文摘 | QI D H BERGER A J | 2007 | Applied Optics2007，46，10： | 1 |
| 14 | Development and evaluation of consensus based sediment quality guidelines for freshwater eeosystems显示文摘 | MacDonald D D Ingersoll C G Berger T A | 2000 | Archives of Environmental Contamination and Toxicology2000，39，1： | 1 |
| 15 | Geologic Stereo Mapping of Geologic Structure with Spot Satellite Data 显示文摘 | Berger Z Lee T H Anderson D W | 1992 | AAPG Bulletin1992，7，6： | 1 |
| 16 | Efficacy and tolerability study of ciclesonide nasal aerosol in patients with perennial allergic rhinitis显示文摘 | Mohar D Berger W E Laforce C | 2012 | Allergy Asthma Proc2012，33，1： | 1 |
| 17 | Conglomeration versus Strategic Focus:Evidence from the Insurance Industry显示文摘 | Berger A N Cummins J D Weiss M A and Zi H | 2000 | Journal of Financial Intermediation2000，9，4： | 1 |
| 18 | Classification of olive oils using high throughput flow 1H NMR fingerprinting with principal component analysis,linear discriminant analysis and probabilistic neural networks显示文摘 | REZZI S AXELSON D E H(E)BERGER K | | 0，，1： | 1 |
| 19 | Mean platelet vol-ume and prevalence of peripheral artery disease,the Na-tional Health and Nutrition Examination Survey, 1999-2004显示文摘 | Berger J S Eraso L H Xie D | 2010 | Atherosclerosis2010，213，2： | 1 |
| 20 | Extent of Surgical Resection Predicts Seizure Freedom in Low-Grade Temporal Lobe Brain Tumors显示文摘 | Englot D J Han S J Berger M S | 2011 | Neurosurgery2011，70，92： | 1 |
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