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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Surgical stress and cytoskeletal changes in lens epithelial cells following manual and femtosecond laser-assisted capsulotomy显示文摘AIM:To study the effect of mechanical stress on the cytoskeleton in lens epithelial cells following conventional phacoemulsification surgery(CPS)and femtosecond laserassisted cataract surgery(FLACS).METHODS:The cytoskeleton of the epithelial cells of the anterior lens capsules(ALC)removed by CPS and FLACS was examined by immunohistochemistry.Expression of the intermediate filament,glial fibrillary acidic protein(GFAP),and glutamine synthetase(GS)immunoreactivity were detected.In order to map the actin network of cells,fluorescently labeled phalloidin was used.The samples were examined using confocal laser scanning microscopy.RESULTS:GFAP expression was visible in a larger number of the epithelial cells after CPS compared to FLACS.In CPS sample’s epithelial cells,GFAP immunoreactivity indicated robust morphological change.Regarding the actin filaments,the presence of tubular elements connecting epithelial cells,regular actin pattern and marked cortical network after CPS were found.Following FLACS,the actin cytoskeleton of the epithelial cells remained densely structured,and the tubular elements were undetectable,however,the above-mentioned regular actin pattern and the marked cortical network were visible.CONCLUSION:The conventional removal of the ALC induces more robust changes of the cytoskeleton of the lens epithelial cells. | ANDrea Krisztina Sükosd Krisztina Szabadfi Edina Szabó-Meleg Beáta Gáspár Pavel Stodulka Gyorgy SétálóJr Róbert Gábriel Miklós Nyitrai Zsolt Biró Hajnalka Abrahám | 2020 | International Journal of Ophthalmology(English edition)2020，13，6： | 2 |
| 3 | Differential quadrature analysis of deflection, buckling and vibration of beams and rectangular plates 显示文摘 | Wang X Bert C W Stirz A G | 1993 | Computers & Structures1993，48，3： | 1 |
| 4 | The role of positive interactions in communities: Lessons from intertidal habitats显示文摘 | BERTNESS M D LEONARD G H | 1997 | Ecology1997，78，： | 1 |
| 5 | Changes in respiration of fresh-cut butlerhead lettuce under controlled atmospheres using low and superatmospheric oxygen conditions with different carbon dioxide levels显示文摘 | ESCALONA V H BERT E V SABINE G | 2006 | Postharvest Biology and Technology2006，39，1： | 1 |
| 6 | Effects of crea- tine supplementation and exercise training on fitness in males 55 to 75 years old 显示文摘 | Bert OE Marc VL Marina G | 2003 | J Appl Physiol2003，95，： | 1 |
| 7 | The role of positive interactions in communities: lessons from intertidal habitats显示文摘 | BERTNESS M D LEONARD G H | 1997 | Ecology1997，78，： | 1 |
| 8 | Mi-croRNAs as regulators of epithelial-mesenchymal tran-sition显示文摘 | Gregory P A Bracken C P Bert A G Goodall G J | 2008 | Cell Cycle2008，7，： | 1 |
| 9 | Tlie influence of atmospheric CO2 enrichment on plant-soil nitrogen interactions in a wetland plantcommunity on the Chesapeake Bay显示文摘 | Roser Matamala Bert G Drake | 1999 | Plant and Soil1999，210，： | 1 |
| 10 | The mir-200 family and mir-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1显示文摘 | GREGORY P A BERT A G PATERSON E L | 2008 | Nature Cell Biolo- gy2008，10，5： | 1 |
| 11 | Systemic accident risk assessment in air traffic by Monte Carlosimulation显示文摘 | Sybert H Stroeve Henk A P Blom G J(Bert)Bakker | 2009 | Safety Science2009，47，2： | 1 |
| 12 | A novel cell culture model for studying differentiation and apoptosis in the mouse mammary gland显示文摘 | Katrina E G Bert B Rachel S C | 2000 | Breast Cancer Res2000，2，3： | 1 |
| 13 | Differential quadrature analysis of deflection, bucking, and free vibration of beams and rectangular plates显示文摘 | Wang X Bert C W Striz A G | 1993 | Computers & Structures1993，48，3： | 1 |
| 14 | A novel cell culture model for studying differentiation and apoptosis in the mouse mammary gland 显示文摘 | KATRINA E G BERT B RACHEL S C | 2000 | Breast Cancer Res2000，2，3： | 1 |
| 15 | Two new approximate methods for analyzing free vibration of structural components 显示文摘 | Bert C W Kang S K Striz A G | 1988 | American Institute of Aeronautics and Astronautics Journal1988，26，： | 1 |
| 16 | Prognosis of elderly patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention in 2001 to 2011: A report from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) registry显示文摘 | Velders M A James S K Libungan B Sarno G Fr?bert O Carlsson J | 2014 | Am Heart J2014，167，： | 1 |
| 17 | Pregnancy in postural tachycardia syndrome: Clinical course and maternal and fetal outcomes显示文摘 | Blitshteyn S Poya H Bert G C | 2012 | The Journal of Maternal-fetal&NeonatalMedicine2012，25，9： | 1 |
| 18 | A new approach to the differential quadrature method for fourth-order equation显示文摘 | Alfred G Bert C W | 1997 | Internat J Numer Methods Engrg1997，40，11： | 1 |
| 19 | The mill-200 family and mill-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1显示文摘 | GREGORY P A BERT A G PATERSON E L | 2008 | Nat Cell Biol2008，10，5： | 1 |
| 20 | Differential quadrature analysis of deflection, buckling, and free vibration of beams and rectangular plates显示文摘 | Bert C W Wang X Striz A G | 1993 | Computers &Structures1993，48，3： | 1 |
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