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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Damage Evaluation of Concrete Test Specimens Related to Failure Analysis 显示文摘 | Berthelot J M Robert J L | 1990 | Journal of Engineering Mechanics ASCE1990，116，3： | 1 |
| 3 | Decision framework for chemotherapeutic interventions for metastatic non-small-cell lung cancer显示文摘 | Berthelot J M Will B P Evans W K | 2000 | J Natl Cancer Inst2000，92，16： | 1 |
| 4 | Damage Evaluation of Con- crete Test Specimens Related to Failure Analysis显示文摘 | Berthelot J M Robert J I | 1990 | Journal of Engineering Mechanics1990，116，3： | 1 |
| 5 | Cheese flavour formation by amino acid catabolism显示文摘 | YVON M BERTHELOT S GRIPON J C | 2001 | International Dairy Journal2001，11，47： | 1 |
| 6 | Site of protonation of nicotine and nornicotine in the gas phase: pyridine or pyrrolidine nitrogen?显示文摘 | Graton J Berthelot M Gal J-F | 2002 | J Am Chem Soc2002，124，10： | 1 |
| 7 | Transverse cracking and delamination in cross- ply glass-fiber and carbon-fiber reinforced plastic laminates: Static and fatigue loading显示文摘 | Berthelot J | 2003 | Applied Mechanics Reviews2003，56，1： | 1 |
| 8 | Essential role forCD103+ cells in the pathogenesis of spondyloarthritides 显示文摘 | Berthelot JM Le Goff B Martin J | 2015 | Joint Bone Spine2015，82，1： | 1 |
| 9 | Development of OPS vitrified pig blastocysts: effects of size of the collected blastocysts, cryoprotectant concentration used for vitrification and number of blastocysts transferred显示文摘 | Berthelot F Venturi E Cognie J | 2007 | Thefiogenology2007，68，2： | 1 |
| 10 | A model for estimating the costs and burdens of breast cancer diagnosis and treatment in Canada显示文摘 | WILL BP BERTHELOT J M HOULE C | 1993 | Health Res1993，5，4： | 1 |
| 11 | Damage evaluation of concrete test specimens related to failure analysis显示文摘 | BERTHELOT J M ROBERT J L | 1990 | Journal of Engineering Mechanics ASCE1990，116，3： | 1 |
| 12 | Holter changes resulting from right-sided and bilateral infrastellate upper thoracic sympa- thectomy 显示文摘 | Abraham P Berthelot J Victor J | 2002 | Ann Thorac Surg2002，74，6： | 1 |
| 13 | Inverted repeat nucleotide sequences in the genomes of Marek disease virus and the herpesvirus of the turkey 显示文摘 | Cebrian J Kaschka-Dierich C Berthelot N | 1982 | Proc Natl Acad Sci USA1982，79，2： | 1 |
| 14 | γ-Secretase modulators as potential disease modifying anti- Alzheimer' s drugs显示文摘 | Oehlrich D Berthelot D J Gijsen HJ | 2010 | J Med Chem2010，54，3： | 1 |
| 15 | New Onset of Uveitis During Anti-Tumor Necrosis Factor Treatment for Rheumatic Diseases显示文摘 | Wendling D Paccou J Berthelot J M | | 0，，： | 1 |
| 16 | Thermoacoustic raditation of sound by a moving laser source显示文摘 | Berthelot Y H Busch-Vishniac I J | 1987 | The Journal of the Acoustical Society of America1987，81，2： | 1 |
| 17 | Decision framework for chemotherapeutic interventions for metastatic non-small-cell lung cancer显示文摘 | Berthelot J M Will B P Evans W K | 2000 | J Natl Cancer Inst2000，92，16： | 1 |
| 18 | The severe form of type I hyperprolinaemia results from Homozygous inactivation of the PRODH gene显示文摘 | H Jacquet J Berthelot | 2003 | J Med Genet2003，40，1： | 1 |
| 19 | Stiffness reduction and energy release rate of cross-ply laminates during fatigue tests显示文摘 | El Mahi A Berthelot J M Brillaud J | 1995 | Composite Structures1995，30，2： | 1 |
| 20 | Antiperinuclear factors are present in polyarthritis before ACR criteria for rheumatoid arthritis are fulfilled显示文摘 | Mauga Y Castagne A | 1997 | Ann Rheum Dis1997，56，2： | 1 |
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