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| 1 | 石见穿化学成分的提取分离及定量分析显示文摘目的:研究石见穿全草的水溶性化学成分及进行含量分析。方法:利用水提、有机溶剂萃取及采用葡聚糖凝胶LH-20柱进行分离纯化,采用HPLC进行定量分析;结果:从石见穿水提取物中分得丹参素和迷迭香酸。HPLC色谱条件下,丹参素进样量在1.48~7.40μg范围内与峰面积积分值呈良好线性关系(r=0.999 9),丹参素加样回收率(按丹参素钠计算)平均值为102.8%,RSD=1.04%;原儿茶醛进样量在0.05~0.26μg范围内与峰面积积分值呈良好线性关系(r=0.999 9),原儿茶醛加样回收率平均值为101.5%,RSD=0.72%。结论:为石见穿的质量控制提供了可靠的检测方法。丹参素为首次从该植物中分离得到。 | 康琛 李曼玲 王谦 黄璐琦 Franco Francesco Vincieri Anna Rita Bilia | 2009 | 中国实验方剂学杂志2009，15，7： | 11 |
| 2 | Andrographolide Loaded in Micro-and Nano-Formulations: Improved Bioavailability, Target-Tissue Distribution, and Efficacy of the “King of Bitters”显示文摘Andrographolide (AG) is the characteristic constituent of Andrographis paniculata, of the Acanthaceae family. This plant is a well-known Asian medicinal plant that is widely used in India, China, and Thailand. A monograph of Herba Andrographidis (Chuanxinlian) is included in the Chinese Pharmacopoeia, which reports that this decoction can “remove heat, counteract toxicity, and reduce swellings.” The numerous potential activities of AG range from anti-inflammatory to anti-diabetic action, from neuroprotection to antitumor activity, and from hepatoprotective to anti-obesity properties. However, AG has low bioavailability and poor water solubility, which can limit its distribution and accumulation in the body after administration. In addition, AG is not stable in gastrointestinal alkaline and acidic environments, and has been reported to have a very short half-life. Among the diverse strategies that have been adopted to increase AG water solubility and permeability, the technological approach is the most useful way to develop appropriate delivery systems. This review reports on published studies related to microparticles (MPs) and nanoparticles (NPs) loaded with AG. MPs based on polylactic-glycolic acid (PLGA), alginic acid, and glucan derivatives have been developed for parenteral oral and pulmonary administration, respectively. NPs include vesicles (both liposomes and niosomes);polymeric NPs (based on polyvinyl alcohol, polymerized phenylboronic acid, PLGA, human serum albumin, poly ethylcyanoacrylate, and polymeric micelles);solid lipid NPs;microemulsions and nanoemulsions;gold NPs;nanocrystals;and nanosuspensions. Improved bioavailability, target-tissue distribution, and efficacy of AG loaded in the described drug delivery systems have been reported. | Marta Casamonti Laura Risaliti Giulia Vanti Vieri Piazzini Maria Camilla Bergonzi Anna Rita Bilia | 2019 | Engineering2019，5，1： | 5 |
| 3 | Flavans and A-Type proanthocyanidines from Prunus prostrata 显示文摘 | BILIA A R MORELLI I HAMBURGER M | 1996 | Phytochemistry1996，43，4： | 1 |
| 4 | An acetylated flavanone glucoside from leaves of Pyrancantha coccines显示文摘 | Bilia A R Catalano S Morelli I | 1991 | Phytochemistry1991，30，11： | 1 |
| 5 | Hypericins as potential leads for new thera peutics显示文摘 | Karioti A Bilia AR | 2010 | Int J MolSci2010，11，2： | 1 |
| 6 | Hypericins as potential leads for newtherapeutics显示文摘 | Karioti A Bilia AR | 2010 | Int J Mol Sci2010，11，： | 1 |
| 7 | Two glucosides from Pyracantha collinea roots显示文摘 | Bilia A R Morelli I Marsili A | 1994 | Tetrahedron1994，50，17： | 1 |
| 8 | Kava-Kava and anxiety:growing knowledge about the efficacy and safety 显示文摘 | Bilia A R Gallori S Vincieri F F | 2002 | Life Sciences2002，70，： | 1 |
| 9 | Ginkgo biloba显示文摘 | Bilia A R | 2002 | Fitoterapia2002，73，3： | 1 |
| 10 | Simultaneous analysis of artemisinin and flavonoids of several extracts of Ar- temisia annua L obtained from a commercial sample and a selected cuhivar显示文摘 | Bilia A R de Malgalhaes P M Bergonzi M C | 2006 | Phytomedicine2006，13，7： | 1 |
| 11 | The Crystal Structure of Human Telomeric DNA Complexed with Berberine:an Interesting Case of Stacked Ligand to G-tetrad Ratio Higher than 1∶1显示文摘 | BAZZICALUPI C FERRARONI M BILIA A B | 2013 | Nuc Aci Res2013，41，1： | 1 |
| 12 | Ginkgo biloba 显示文摘 | Bilia A R | 2002 | Fitoterapia2002，73，3： | 1 |
| 13 | Flavans and A-type proanthocyanidins from Prunus prostrata显示文摘 | A.R. Bilia I. Morelli M. Hamburger K. Hostetmann | 1996 | Phytochemistry1996，，4： | 1 |
| 14 | The MM, ME, ML, EL, EF and GMM approaches to estimation: a synthesis显示文摘 | Anil K Bera Yannis Bilias | 2002 | Journal of Econometrics2002，107，： | 1 |
| 15 | Rao's score,Neyman's C (4) and Silvey's LM tests显示文摘 | Bera A K Bilias Y | 2001 | Journal of Statistical Planning and Inference2001，97，： | 1 |
| 16 | Coumarins and other constituents of Prunus prostrata显示文摘 | Bilia A R Cecchini C Marsili A Morelli I Mele S | 1993 | J Nat Prod1993，56，12： | 1 |
| 17 | Phytochemical in vestigations of licania genus:Flavonoids and triterpenes from Licania carii显示文摘 | BILIA A R MORELLI J M I | 1996 | Pharmaceutica Acta Helvetiae1996，71，： | 1 |
| 18 | Science meets regulation显示文摘 | BILIA AR | 2014 | J Ethnopharmacol2014，158，： | 1 |
| 19 | Myricetin glycosides from Licania densiflora 显示文摘 | Braca A Bilia A R Mendez J | 2001 | Fitoterapia2001，72，： | 1 |
| 20 | Flavans and a-type proanhocyanidins from prunus prostrate 显示文摘 | BILIA A R MORELLI L HAMBURGER M | 1996 | Phytocchemistry1996，36，4： | 1 |
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