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| 1 | Pluronic L-81 ameliorates diabetic symptoms in db/db mice through transcriptional regulation of microsomal triglyceride transfer protein显示文摘AIM: To test whether oral L-81 treatment could im-prove the condition of mice with diabetes and to investigate how L-81 regulates microsomal triglyceride transfer protein (MTP) activity in the liver. METHODS: Genetically diabetic (db/db) mice were fed on chow supplemented with or without L-81 for 4 wk. The body weight, plasma glucose level, plasma lipid profile, and adipocyte volume of the db/db mice were assessed after treatment. Toxicity of L-81 was also evaluated. To understand the molecular mecha-nism, HepG2 cells were treated with L-81 and the effects on apolipoprotein B (apoB) secretion and mRNA level of the MTP gene were assessed.RESULTS: Treatment of db/db mice with L-81 sig-nificantly reduced and nearly normalized their body weight, hyperphagia and polydipsia. L-81 also markedly decreased the fasting plasma glucose level, improved glucose tolerance, and attenuated the elevated levels of plasma cholesterol and triglyceride. At the effective dosage, little toxicity was observed. Treatment of HepG2 cells with L-81 not only inhibited apoB secretion, but also signif icantly decreased the mRNA level of the MTP gene. Similar to the action of insulin, L-81 exerted its effect on the MTP promoter. CONCLUSION: L-81 represents a promising candidate in the development of a selective insulin-mimetic mol-ecule and an anti-diabetic agent. | Wo-Shing Au Li-Wei Lu Sidney Tam Otis King Hung Ko Billy KC Chow Ming-Liang He Samuel S Ng Chung-Man Yeung Ching-Chiu Liu Hsiang-Fu Kung Marie C Lin | 2009 | World Journal of Gastroenterology2009，15，24： | 1 |
| 2 | Copper intraocular foreign body:diagnosis and treatment显示文摘 | Billi B Lesnoni G Scassa C | 1995 | Eur J Ophthalmol1995，5，4： | 1 |
| 3 | Thermal decomposition of the oxynitride of silicon 显示文摘 | Ehlert T C Dean T P Billy M | 1980 | J Am Ceram Soc Disc and Notes1980，63，34： | 1 |
| 4 | Preparation and properties of new silicon oxynitride based ceramics显示文摘 | Billy M Boch P Dumazeau C | 1998 | Ceram [nt1998，7，1： | 1 |
| 5 | Squamous and/or glandular differentiation in urnthelial carcinoma: prevalence and significance in transurethral resections of the bladder显示文摘 | Billis A Schenka A A Ramos C C | 2001 | Int Urol Nephrol2001，33，4： | 1 |
| 6 | Copper intraocular foreign body:diagnosis and treatment显示文摘 | Billi B Lesnoni G Scassa C | 1995 | Eur J Ophthalmol1995，5，4： | 1 |
| 7 | Biotransformation of Nitrobenzene by bacteria cantaining toluene degradative pathways显示文摘 | BILLY E H SPAIN J C | 1991 | Appl Environ Microbiol1991，57，11： | 1 |
| 8 | The environmental scanning electron microscope: a new tool for textile studies 显示文摘 | Weiying Tao Billie J C | 2009 | Textile Chemist & Colorist2009，，2： | 1 |
| 9 | Four genes of Medicago truncatula controlling components of a Nod factor transduction pathway显示文摘 | CATOIRA R GALERA C DE BILLY F | 2000 | The Plant Cell Online2000，12，9： | 1 |
| 10 | Treatment of tuberculosis infection 显示文摘 | Billy C Perronne C | 2002 | Ann Med Interne (Paris)2002，153，2： | 1 |
| 11 | Four genes of Medica- go truncatula controlling components of a Nod faetor transduc- tion pathway显示文摘 | Catoira R Galera C de Billy F | 2000 | The Plant Cell2000，12，9： | 1 |
| 12 | Treatment of neglected Mon-teggia's fracture by ulnar lengthening using the Ilizarov technique显示文摘 | Gicquel P De Billy B Karger C | 2000 | Rev Ghir Orthop Reparatrice Appar Mot2000，86，8： | 1 |
| 13 | Western European epidemiological survey for parvovirns and coronavirns in- fections in dogs 显示文摘 | Deearo N Desario C Billi M | 2011 | The Veterinary Journal2011，187，2： | 1 |
| 14 | Production of α-1,3-galactosyltransferase knockout Pigs by nuclear transfer cloning显示文摘 | Donna K S Kwang W P Hee T C Julia L G Gi S I Melissa S Aaron B August R Billy N D Clifton N M David B C Robert J H Randall S P | 2002 | Science2002，295，5557： | 1 |
| 15 | The Environmental Scanning Electron Microscope:a New Tool for Textile Studies显示文摘 | Billie J C | 1994 | Textile Chemist & Colorist1994，，2： | 1 |
| 16 | Finite element analysis of the propagation of acoustic waves along waveguides immersed in water显示文摘 | Hladky-Hennion A C Langlet P de Billy M | 1997 | Journal of Sound and Vibration1997，200，4： | 1 |
| 17 | Direct observation of Anderson localization of matter waves in a con- trolled disorder显示文摘 | Billy J Josse V Zuo Z C | 2008 | 453:8912008，453，： | 1 |
| 18 | Squamous and/or glandular differentiation in urothelial carcinoma: prevalence and significance in transurethral resections of the bladder显示文摘 | BILLIS A SCHENKA A A RAMOS C C | 2001 | Int Urol Nephro12001，33，4： | 1 |
| 19 | Copper intraocular foreign body:diagnosis and treatment显示文摘 | Billi B Lesnoni G Scassa C | 1995 | Eur J Ophthalmol1995，5，4： | 1 |
| 20 | Free radicalscavenging as effeted accele rated ageing abd subice-quent priming in sunflower seeds显示文摘 | Billy C Benamar A Corbineau F | 1998 | Phusiol Plant1998，104，： | 1 |
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