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| 1 | Protective effect of resveratrol against cadmium-induced toxicity on ovine oocyte in vitro maturation and fertilization显示文摘Background:Heavy metal cadmium(Cd)is a widespread environmental contaminant with a potential toxicity that might negatively affect female reproduction and fertility.It has been reported that Cd exposure impaired the quality of oocytes and led to a defective maturation and fertilization,through oxidative stress induction.Resveratrol(Res)is a natural polyphenol with strong antioxidant properties that exhibited protective role in preventing oocyte redox homeostasis disruption and quality decline.Here,we explored whether the addition of Res to in vitro maturation(IVM)medium might act as a protection against Cd-induced toxicity on ovine oocyte maturation and fertilization.Firstly,we evaluated the effect of supplementing IVM medium with two different Res concentrations(1and 2μmol/L)on nuclear maturation and fertilization of oocytes matured under CdCl2(2μmol/L)exposure.Therefore,the concentration of 1μmol/L Res was selected to analyse the effects of this compound on intracellular ROS levels,mitochondrial(mt)distribution and activity,chromatin configuration,cytoskeleton morphology,cortical granules(CGs)distribution and mRNA expression of genes associated with cellular response to oxidative stress(i.e.SIRT1,SOD 1,GPX1,GSR,CAT)in Cd-exposed in vitro matured oocytes.Results:We found that 1μmol/L Res restored the reduced oocyte meiotic competence induced by Cd exposure as well as,Res sustained oocyte ability to be normally fertilized and decreased polyspermic fertilization at both tested concentrations.Moreover,we demonstrated that 1μmol/L Res mitigated Cd-induced alterations of oocyte cytoplasmic maturation by reducing reactive oxygen species(ROS)accumulation,preventing mt dysfunction,maintaining the correct meiotic spindle and cortical F-actin assembly and the normal cortical granule distribution as well as up-regulating SIRT1,SOD1 and GPX1 genes.Conclusions:Taken together,our findings highlighted the beneficial influence exerted by Res in preventing Cdinduced disturbance of nuclear and cytoplasmic maturation and subsequent fertilization in ovine oocytes.Res treatment may help to establish defence strategies counteracting Cd-induced toxicity on the female gamete. | Anna Rita Piras Federica Ariu Alessio Maltana Giovanni Giuseppe Leoni Nicola Antonio Martino Antonella Mastrorocco Maria Elena Dell’Aquila Luisa Bogliolo | 2023 | Journal of Animal Science and Biotechnology2023，14，1： | 3 |
| 2 | Meiotic progression and developmental competence of oocytes collected from juvenile and adult ewes显示文摘 | Ledda S Bogliolo L Calvia P | 1997 | J Reprod Fertil1997，109，： | 1 |
| 3 | Antibodies to cyclic citndlinated peptides in psoriatic aahritis显示文摘 | Bogliolo LAlpini C Caporali K | 2005 | Rheumatol2005，32，： | 1 |
| 4 | A survey of design techniques for system-level dynamic power management 显示文摘 | Benini L Bogliolo A Micheli G D | 2000 | IEEE Transactions on VLSI Systems2000，8，3： | 1 |
| 5 | Performance Analysis of Arbitration Policies for SoC Communication Architectures显示文摘 | Francesco Poletti Davide Bertozzi Luca Benini Alessandro Bogliolo | 2003 | Design Automation for Embedded Systems (-)2003，，2： | 1 |
| 6 | Axillary reverse mapping in breast cancer:a new microsurgical lymphatic-venous procedure in the prevention of arm lymphedema显示文摘 | Casabona F Bogliolo S Ferrero S | 2008 | Ann Surg Oncol2008，15，11： | 1 |
| 7 | A Survey of Design Techniques for System-Level Dynamic Power Management 显示文摘 | Luca Benini Alessandro Bogliolo | 2000 | IEEE Transactions on Very Large Scale Integration (VLSI) Systems2000，8，3： | 1 |
| 8 | A survey of design techniques for system-level dynamic power management 显示文摘 | Benini L Bogliolo A Micheli G D | 2000 | IEEE Trans on Very Large Scale Integration (VLSI) Systems2000，8，3： | 1 |
| 9 | Feasibility of axillary reverse mapping during sentinel lymph node biopsy in breast cancer patients显示文摘 | Casabona F Bogliolo S Valenzano Menada M | 2009 | Ann Surg Oncol2009，16，9： | 1 |
| 10 | Policy optimization for dynamic power management显示文摘 | BENINI L BOGLIOLO A PALEOLOGO G | 1999 | IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems1999，18，6： | 1 |
| 11 | A Survey of Design Techniques for System-Level Dynamic Power Management显示文摘 | Luca Benini Alessandro Bogliolo Giovanni De Micheli | 2000 | IEEE Transactions on Very Large-Scale Integration Systems2000，8，3： | 1 |
| 12 | Dynamic power management for nonstationary service requests显示文摘 | Hung E Y Benini L Bogliolo A | 2002 | IEEE Trans on Computers2002，51，11： | 1 |
| 13 | Dynamic power management for nonstationary service requests 显示文摘 | Eui Y C Benini L Bogliolo A | 2002 | IEEE Transaction on Computers2002，51，11： | 1 |
| 14 | A survey of design techniques for system-level dynamic power management显示文摘 | BENINI L BOGLIOLO A DE MICHELI G | 2000 | IEEE Trans Very Large Scale Integr Syst2000，8，3： | 1 |
| 15 | Policy optimization for dynamic power management 显示文摘 | Benini L Bogliolo A Paleologo G | 1999 | IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems1999，18，6： | 1 |
| 16 | Feasibility of axillary reverse mapping during sentinel lymph node biopsy in breast cancer patients显示文摘 | Casabona F Bogliolo S Valenzano Menada M | 2009 | Ann Surg oncol2009，16，9： | 1 |
| 17 | Dynamic power management for lionstationary service requests显示文摘 | HUNG E Y BENINI L BOGLIOLO A | 2002 | IEEE Transaction on Computers2002，51，11： | 1 |
| 18 | Expression pattern of zygote arrest 1 (ZAR1), maternal antigen that embryo requires (MATER), growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) genes in ovine oocytes and in vitro- produced preimplantation embryos显示文摘 | Bebbere D Bogliolo L Ariu F | 2008 | Reprod Fertil Dev2008，20，： | 1 |
| 19 | A survey of design techniques for system-level dynamic power management显示文摘 | Benini Luca Bogliolo Alessandro de Micheli Giovanni | 2000 | IEEE Transactions on Very Large Scale Integration (VLSI) Systems2000，8，3： | 1 |
| 20 | A smokey of design techniques for system-level dynamic power management显示文摘 | Benini L Bogliolo A Micheli G D | 2000 | IEEE Transactions on VLSI Systems2000，8，： | 1 |
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