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| 1 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 2 | Effect of post-slaughter processing and freezing on the functionality of hot-boned meat from young bull 显示文摘 | BOLES J A SWAN J E | 1996 | Meat Science1996，44，： | 1 |
| 3 | Weaning from mechanical ventilation 显示文摘 | Boles JM Bion J Connors A | 2007 | Eur Respir J2007，29，5： | 1 |
| 4 | Weaning from mechanical ventilation显示文摘 | Boles JM Bion J Connors A | 2007 | Eur Res J2007，29，5： | 1 |
| 5 | Effect of monensin on performance and plasma metabolites in growing-finishing steers显示文摘 | Gay J A Boling N W | 1978 | J Anim Sci1978，，46： | 1 |
| 6 | A fiber-opticDNA biosensor microarrary for the analysis of gene expression显示文摘 | Boles T C Adams C P | 1996 | Nat Biochnol1996，14，13： | 1 |
| 7 | ldentification and expression pattem of cationic amino acid transporter-1 mRNA in small intestinal epithelia of Angus steers at four production stages显示文摘 | Liao S F Vanzant E S Boling J A | 2008 | Anim Sci2008，86，： | 1 |
| 8 | Weaning from mechanical ventilation显示文摘 | Boles J Bion A Connors M | | 0，，： | 1 |
| 9 | Com- plete biological control of Antonina graminis in teas with Neodusmetia sangwani (a classic example) 显示文摘 | DEAN H A SCHUSTER M F BOLING J C | 1979 | Bull Ento- mol Soc Am1979，25，： | 1 |
| 10 | Weaning from mechanical ventilation 显示文摘 | Boles JM Bion J Connors A | 2007 | Eur Respir J2007，29，5： | 1 |
| 11 | Effect of dietary protein level on nitrogen metabolism in lambs: studies using is N-nitrogen显示文摘 | Bunting L D Boling J A MacKown C T Muntifering R B | 1987 | Journal of Animal Science1987，64，： | 1 |
| 12 | Inhibitors of HMGCoA reductase and risk of fracture among older women显示文摘 | Chan K A Andrade S E Boles M | 2000 | Lancet2000，355，： | 1 |
| 13 | Weaning from mechan- ical ventilation显示文摘 | Boles JM Bion J Connors A | 2007 | Eur Respir J2007，29，5： | 1 |
| 14 | Lipid coating as a mode of protecting free methionine from ruminal degradation显示文摘 | Smith S I Boling J A | 1984 | J Anim Sci1984，58，： | 1 |
| 15 | Effects of brine ingredient and temperature on cook yields and tenderness of pe-rigor processed roast beef显示文摘 | J A Boles J E Swan | | 0，，： | 1 |
| 16 | Synovial plieae in the knee显示文摘 | Boles C A Martin D F | 2001 | AJR2001，177，1： | 1 |
| 17 | Weaning from mechanical ventilation显示文摘 | Boles JM Bion J Connors A | 2007 | Eur Respir J2007，29，5： | 1 |
| 18 | Knowledge-based collision avoidance显示文摘 | COENEN F P SNEATON G P BOLE A G | 1989 | The Journal of Navigation1989，42，1： | 1 |
| 19 | Meat color stability affected by barley variety fed in finishing diet to beef steers显示文摘 | BOLES J A BOWMAN J G P | 2005 | Meat Science2005，70，： | 1 |
| 20 | Weaning from mechanical ventilation 显示文摘 | Boles JM Bion J Connors A | 2007 | Eur Respir J2007，29，5： | 1 |
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