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| 1 | Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases显示文摘Hepatocyte nuclear factor 4-alpha(HNF4α)is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs(pancreas,stomach,and intestine).In liver,HNF4αis best known for its role as a master regulator of liver-specific gene expression and essential for adult and fetal liver function.Dysregulation of HNF4αexpression has been associated with many human diseases such as ulcerative colitis,colon cancer,maturity-onset diabetes of the young,liver cirrhosis,and hepatocellular carcinoma.However,the precise role of HNF4αin the etiology of these human pathogenesis is not well understood.Limited information is known about the role of HNF4αisoforms in liver and gastrointestinal disease progression.There is,therefore,a critical need to know how disruption of the expression of these isoforms may impact on disease progression and phenotypes.In this review,we will update our current understanding on the role of HNF4αin human liver and gastrointestinal diseases.We further provide additional information on possible use of HNF4αas a target for potential therapeutic approaches. | Matthew M Yeh Dustin E Bosch Sayed S Daoud | 2019 | World Journal of Gastroenterology2019，25，30： | 5 |
| 2 | Fluoro scopic positioning of sacroiliac serews in 88 patients显示文摘 | Van den Bosch E W Van Zwienen C M Van Vugt A B | 2002 | JTrauma2002，53，1： | 1 |
| 3 | Thermal processing of whole soya beans: Studies on the inactivation of antinutritional factors and effects on ileal digestibility in piglets显示文摘 | Qin G Ter Elst E R Bosch M W | 1996 | Anita Feed Sci Tech1996，57，： | 1 |
| 4 | A rapid solidphase fluorimetric may for measuring bacterial adherence, using DNA- binding stains 显示文摘 | BOSCH J A VEERMAN E C TURKENBURG M | 2003 | Microbiol Methods2003，53，1： | 1 |
| 5 | Pasteurella mul- tocida exbB, exbD and tonB genes are physically linked but independently transcribed显示文摘 | Bosch M Garrido E Llagostera M | 2002 | FEMS Microbiol Lett2002，210，： | 1 |
| 6 | Heterologousprotective immunization elicited in mice by Pasteurella multo-cidafur ompH显示文摘 | GARRIDO M E BOSCH M BIGAS A | 2008 | Int Microbiol2008，11，1： | 1 |
| 7 | Effect of the Carbon Source on Biosurfactant Production by Pseudomonas Aeruginosa 44T1显示文摘 | Robert M Mercado M E Bosch M P | 1989 | Bioethanol Lett1989，11，： | 1 |
| 8 | Expression of the Pasteurella multocida ompH gene is negatively regula- ted by the Fur protein显示文摘 | BOSCH M TARRAG R GARRIDO M E | 2001 | FEMS Microbiol Lett2001，203，1： | 1 |
| 9 | Rhabdomyolysis and acute kidney injury显示文摘 | BOSCH X POCH E GRAU J M | 2009 | New England Journal of Medicine2009，361，1： | 1 |
| 10 | Heterologous protectiveimmunization elicited in mice by Pasteurella multocida furOmpH显示文摘 | Garrido M E Bosch M Bigas A | 2008 | Int Microbiol2008，11，1： | 1 |
| 11 | Localiza- tion of a rapid CSF leak with digital subtraction myelog- raphy 显示文摘 | Hoxworth J M Patel A C Bosch E P | 2009 | AJNR Am J Neuroradiol2009，30，3： | 1 |
| 12 | Associa- tion of C-MYC amplification with progression from the in situ to the invasive stage in C-MYC-amplified breast carcinomas 显示文摘 | Robanus-Maandag E C Bosch C A Kristel P M | 2003 | J Pathol2003，201，1： | 1 |
| 13 | Heterologous protective immunization elicited in mice by Pasteurella multocida fur ompH 显示文摘 | Garrido M E Bosch M Bigas A | 2008 | Int Microbiol2008，11，1： | 1 |
| 14 | Self-incompatibility in Papaver:signalling to trigger PCD in incompatible pollen显示文摘 | BOSCH M FRANKLIN-TONG V E | 2008 | J Exp Bot2008，59，3： | 1 |
| 15 | Thermal processing of whole soya beans : studies on the inactivation of antinutritional factors and effects on ileal digestibility in piglets显示文摘 | Qin G ter Elst E R Bosch M W | 1996 | Anim Feed Sci Technol1996，57，： | 1 |
| 16 | Temporal and spatial da- tivation of Caspase-like enzymes induced by self-ineompatihili- ty显示文摘 | BOSCH M FRANKLIN-TONG V E | 2007 | Proc Natl Acad Sci USA2007，103，18： | 1 |
| 17 | Temporal and spatial activation of caspase-like enzymes induced by self-incompatibility in Papaver pollen显示文摘 | BOSCH M FRANKLIN-TONG V E | 2007 | Proceedings of the National Academy of Sciences2007，104，： | 1 |
| 18 | Delaying the initiation of progesterone supplementation until the day of fertilization does not compromise eycle outcome in patients receiving donated oocytes: a randomized study显示文摘 | Escriba M J Bellver J Bosch E | 2006 | Fertil Steril2006，86，1： | 1 |
| 19 | Expression of the Pasteurella multocida ompH gene is negatively regulated by the Fur protein 显示文摘 | Bosch M Tarrago R Garrido M E | 2001 | FEMS Microbiol Lett2001，203，1： | 1 |
| 20 | Gonadotropin-releasing hormone neurons express KATP channels that are regulated by estrogen and responsive to glucose and metabolic inhibition显示文摘 | Zhang C Bosch M A Levine J E | 2007 | J Neurosci2007，27，10： | 1 |
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