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| 1 | Platelet-rich plasma for muscle injuries: A systematic review of the basic science literature显示文摘BACKGROUND Platelet-rich plasma(PRP) is an increasingly used biologic adjunct for muscle injuries, as it is thought to expedite healing. Despite its widespread use, little is known regarding the mechanisms by which PRP produces its efficacious effects in some patients.AIM To clarify the effects of PRP on muscular pathologies at the cellular and tissue levels by evaluating the basic science literature.METHODS A systematic review of PubMed/MEDLINE and EMBASE databases was performed using the Preferred Reporting Items for Systematic Reviews and MetaAnalyses(PRISMA) guidelines and checklist. Level III in vivo and in vitro studies examining PRP effects on muscles, myocytes and/or myoblasts were eligible for inclusion. Extracted data included PRP preparation methods and study results.RESULTS Twenty-three studies were included(15 in vivo, 6 in vitro, 2 in vitro/in vivo). Only one reported a complete PRP cytology(platelets, and red and white blood cell counts). Five in vitro studies reported increased cellular proliferation, four reported increased gene expression, and three reported increased cellular differentiation. Five in vivo studies reported increased gene expression, three reported superior muscle regeneration, and seven reported improved histological quality of muscular tissue.CONCLUSION The basic science literature on the use of PRP in muscle pathology demonstrates that PRP treatment confers several potentially beneficial effects on healing in comparison to controls. Future research is needed to determine optimal cytology,dosing, timing, and delivery methods of PRP for muscle pathologies. | Kyle N Kunze Charles P Hannon Jared D Fialkoff Rachel M Frank Brian J Cole | 2019 | World Journal of Orthopedics2019，10，7： | 6 |
| 2 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 3 | Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration显示文摘AIM:To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype(SASP).METHODS:Hydrogen peroxide treatment was used to induce senescence in the human Hep G2 hepatocyte cell line.Senescence was confirmed by cytochemical staining for a panel of markers including Ki67,p21,heterochromatin protein 1β,and senescence-associated-β-galactosidase activity.Senescent hepatocytes were characterised by gene expression arrays and quantitative polymerase chain reaction(q PCR),and conditioned media was used in proteomic analyses,a human chemokine protein array,and cell migration assays to characterise the composition and function of the hepatocyte SASP.RESULTS:Senescent hepatocytes induced classical markers of senescence(p21,heterochromatin protein1β,and senescence-associated-β-galactosidase activity);and downregulated the proliferation marker,Ki67.Hepatocyte senescence induced a 4.6-fold increase in total secreted protein(P=0.06)without major alterations in the protein profile.Senescence-induced genes were identified by microarray(Benjamini Hochbergcorrected P<0.05);and,consistent with the increase in secreted protein,gene ontology analysis revealed a significant enrichment of secreted proteins among inducible genes.The hepatocyte SASP included characteristic factors such as interleukin(IL)-8 and IL-6,as well as novel components such as SAA4,IL-32and Fibrinogen,which were validated by q PCR and/or chemokine protein array.Senescent hepatocyteconditioned medium elicited migration of inflammatory(granulocyte-macrophage colony stimulating factor,GM-CSF-derived),but not non-inflammatory(CSF-1-derived)human macrophages(P=0.022),which could contribute to a pro-inflammatory microenvironment in vivo,or facilitate the clearance of senescent cells.CONCLUSION:Our novel model of hepatocyte senescence provides insights into mechanisms by which senescent hepatocytes may promote chronic liver disease pathogenesis. | Katharine M Irvine Richard Skoien Nilesh J Bokil Michelle Melino Gethin P Thomas Dorothy Loo Brian Gabrielli Michelle M Hill Matthew J Sweet Andrew D Clouston Elizabeth E Powell | 2014 | World Journal of Gastroenterology2014，20，47： | 2 |
| 4 | Interfacial turbulence during the absorption of carbon dioxide into monoethanolamine显示文摘 | Brian P L T Vivian J E Matiatos D C | 1967 | AIChE J1967，13，： | 1 |
| 5 | Cystic fibrosis显示文摘 | Brian P O’Sullivan Steven D Freedman | 2009 | The Lancet . 2009 (9678)2009，，： | 1 |
| 6 | A method for assessing hydrologic alteration within ecosystems显示文摘 | Brian D Riehter Jeffrey V Baumgartner David P Braun | 1996 | Conservation Biology1996，10，4： | 1 |
| 7 | Simultaneous inversion of pre-stack seismic data 显示文摘 | Hampson D P Brian H R Brad P B | 2005 | Expanded Abstracts of 75th Annual Internat SEG Mtg2005，，： | 1 |
| 8 | Representation of DNA sequences in recombinant DNA libraries prepared by restriction enzyme partial digestion 显示文摘 | Brian S Richard C P Normen D | 1982 | Gene1982，19，： | 1 |
| 9 | Use of plasma brain natriuretic peptide concentration to aid in the diagnosis of heart failure显示文摘 | Brian P Shapiro M D Homg H | 2003 | Mayo elinproe2003，78，6： | 1 |
| 10 | Dynamic Measurements of Corrosion Rates at High Temperatures in High Electrical Resistivity Media显示文摘 | BRIAN N P RAJASHREEE C THOMAS M D | 2015 | Corrosion Science2015，94，： | 1 |
| 11 | Non- contingent Reinforeement:A Further Examination of Sched- ule Effects During Treatment显示文摘 | Wallace Michele D Iwata Brian A Hanley Gregory P | 2012 | Journal of Applied Behav- ior Analysis2012，，45： | 1 |
| 12 | Extended dormancy of deciduous woody plants treated in autumn with gibberellic acid 显示文摘 | Brian P D Petty J P Richmond P T | 1959 | Nature1959，184，： | 1 |
| 13 | Population aging and future carbon emissions in the United States 显示文摘 | MICHAEL D BRIAN O N ALEXIA P | 2008 | Energy Eco- nomics2008，，30： | 1 |
| 14 | The radial artery in coronary surgery: a 5-year experience—clinical and angiographic results显示文摘 | James Tatoulis Alistair G Royse Brian F Buxton John A Fuller Peter D Skillington John C Goldblatt Robin P Brown Michael A Rowland | 2002 | The Annals of Thoracic Surgery2002，，： | 1 |
| 15 | Ecosystem growth and development显示文摘 | BRIAN D F JORGENSEN S E BERNARD C P | 2004 | BioSystems2004，，77： | 1 |
| 16 | The (1, 3)-β-D-Glu- can test as an aid to early diagnosis of invasive fungal infections following lung transplantation 显示文摘 | Barbara D Alexander P Brian S at al | 2010 | Clin Mierobiol2010，48，11： | 1 |
| 17 | Inflammation at the Molecular Interface of Atherogenesis显示文摘 | Brian D Lamon David P | 2008 | The American Journal of Pathology2008，173，5： | 1 |
| 18 | Inhibition of rooting of cuttings by gibberellic acid: with one figure in the text显示文摘 | Brian P W Hemming H G Lowe D | 1960 | Annals of Botany1960，24，4： | 1 |
| 19 | Formation of an N- formylkynurenine-derived fluorophore and its use for measuring indoleamine 2,3-dioxygenase 1 activity 显示文摘 | Petr T Brian D P Jack U F | 2013 | Anal Bioanal Chem2013，405，8： | 1 |
| 20 | Cohort Study of Pioglitazone and Cancer Incidence in Patients With Diabetes显示文摘 | Ferrara Assiamira Lewis James D Quesenberry Charles P Peng Tiffany Strom Brian L Van Den Eeden Stephen K Ehrlich Samantha F Habel Laurel A | 2011 | Diabetes Care2011，，4： | 1 |
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