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| 1 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 2 | Some sufficient conditions for a planar graph of maximum degree six to be class 1显示文摘 | BU Y WANG W | 2006 | Discrete Math2006，306，13： | 1 |
| 3 | Polyoxometalates matrixed into surfactants: synthesis, characterizations, and conformations of surfactants 显示文摘 | BU W F WU L X TANG A Q | 2004 | J Colloid Interf Sci2004，269，： | 1 |
| 4 | Anti-coagulation effect of Fc fragment against anti-βz-GP 1 antibodies in mouse models with APS显示文摘 | Xie W Zhang Y Bu C | 2010 | lnt Immunophamacol2010，11，： | 1 |
| 5 | Antidiabetic effect of ginsengoside Rb3 in alloxan-induced diabetic mice 显示文摘 | BU Q T ZHANG W Y CHEN Q C et a l | 2012 | Med Chem2012，8，5： | 1 |
| 6 | Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6transgenic mice:impli-cation for breast cancer tumorigenesis显示文摘 | Zhang J Li Y Liu Q Lu W Bu G | 2010 | Oncogene2010，29，4： | 1 |
| 7 | Spectroscopic characterization of hot-water extractable organic matter from soils under four different vegetation types along an etevation gradient in theWuyi Mountains显示文摘 | Bu X L Wang L M Ma W B | 2010 | Geoderma2010，159，： | 1 |
| 8 | The expression of ARHI in pT2a and pT2b stage gastric cancer and its clinical significance显示文摘 | Wang W Bu XM Wang J | 2012 | Oncol Rep2012，27，6： | 1 |
| 9 | Nonsingular direct neural control of air-breathing hypersonic vehicle via back-step- ping显示文摘 | BU X W WU X Y MA Z | 2015 | Neurocomputing2015，153，： | 1 |
| 10 | Self- assembled monolayers of CH3COS -terminated surfactant -encapsulated polyoxometalate complexes 显示文摘 | SUN H BU W F LI Y C | 2008 | Langmuir2008，20，： | 1 |
| 11 | An excitation- capacitor-optimized dual stator-winding induction generator with the static excitation controller for wind power application显示文摘 | BU F F HUANG W X HU Y W | 2011 | IEEE Trans on Energy Conversion2011，26，1： | 1 |
| 12 | Rescue of recombinant peste des petits ruminants virus: crea- tion of a GFP-expressing virus and application in rapid virus neutralization test显示文摘 | Hu Q Chen W Huang K Baron M D Bu Z | 2012 | Vet Res2012，1，2： | 1 |
| 13 | Neural cell cycle dysregulation and central nervous system diseases 显示文摘 | Wang W Bu B Xie M | 2009 | Prog Neurobiol2009，89，1： | 1 |
| 14 | Isolation and characterization of lipid transfer protein(LTP)genes from a wheat-rye translocation line显示文摘 | Jang C S Kim D S Bu S Y Kim J B Lee S S Kim J Y Seo Y W | 2002 | Plant Cell Rep2002，20，： | 1 |
| 15 | Wnt signaling, stem cells, and the cellular origin of breast cancer显示文摘 | Lindvall C Bu W Williams BO | 2007 | Stem Cell Rev2007，3，2： | 1 |
| 16 | Controlling the framework formation of silver(Ⅰ)coordination polymers with 1,4-bis (phenylthio) butane by varying the solvents, metal-to-ligand ratio, and counteranions显示文摘 | Bu X H Chen W Hou W F | 2002 | Inorg Cbem2002，41，： | 1 |
| 17 | Reversible piezochromic luminescence of 9,10-bisanthracenes and the dependence on N-alkyl chain length显示文摘 | Wang Y L Liu W Bu L Y | 2013 | J Mater Chem C2013，，1： | 1 |
| 18 | Nitrogen pollution and source identifica- tion in the Haicheng River basin in Northeast China显示文摘 | Bu H M Meng W Zhang Y | 2011 | Science of the Total Environment2011，409，： | 1 |
| 19 | Human papillomavirus type 16 E7 DNA vaccine: mutation in the open reading frame of E7 enhances specific cytotoxic T-lymphocyte induction and antitumor activity显示文摘 | Shi W Bu P Liu J | | 0，，： | 1 |
| 20 | Multiple ways of tar- geting APOBEC3-virion infectivity factor interactions for anti-HIV-1 drug development显示文摘 | Smith JL Bu W Burdick RC | 2009 | Trends Pharmacol Sci2009，30，12： | 1 |
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