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| 1 | Flow frequency responses to grass conversion and subsequent succession显示文摘 | Burt T P Swank W T | 1992 | Hydrological Processes1992，6，2： | 1 |
| 2 | Quantum chemical studies of a model for peptide bond formation: formation of formamide and water from ammonia and formic acid显示文摘 | Loew G H Burt S K | 1982 | J Am Chem Soc1982，104，： | 1 |
| 3 | Stream nitrate levels in a small catchment in Southwest England over a period of fifteen years显示文摘 | Burt T P Arkell B P Trudgill S T | 1988 | Hydrological Processes1988，2，： | 1 |
| 4 | Hydraulic conductivity in frozen soils 显示文摘 | BURT T P WILLIAMS P J | 1976 | Earth Surf Processes1976，1，： | 1 |
| 5 | Topographic controls of soil moisture distributions 显示文摘 | Burt T P Butcher D P | 1985 | Journal of Soil Science1985，36，3： | 1 |
| 6 | Variation in WNT genes is associated with non - syndromic cleft lip with or without cleft palate显示文摘 | CHIQUET B T BLANTON S H BURT A | 2008 | Hum Mol Genet2008，17，14： | 1 |
| 7 | Neuropsychiatric applications of transcranial magnetic stimulation:A meta analysis显示文摘 | Burt T Lisanby SH Sackeim HA | 2002 | Int J Neuropsychopharmacol2002，5，： | 1 |
| 8 | Irrigation perform measures: Efficiency and uniformity显示文摘 | BURT C M CLEMMENS A J STRELKOFF T S | 1997 | Journal of Irrigation and Drainage Engineering1997，123，6： | 1 |
| 9 | The laplacian pyramid as a compact image code显示文摘 | BURT P ADELSON T | 1983 | IEEE Transactions on Communication1983，31，4： | 1 |
| 10 | Irrigation performance measures: efficiency and uniformity 显示文摘 | Burt C M Clemmens A J Strelkoff T S | 1997 | Journal of Irrigation and Drainage Engineering ASCE1997，123，6： | 1 |
| 11 | Introduction-terminology classification and composition of skam deposit 显示文摘 | Einaudi M T Burt D M | 1982 | Econ Geol1982，77，： | 1 |
| 12 | A protective association between the HLA-A2 antigen and nasopharyngeal carcinoma in US Causians显示文摘 | Burt R D Vaughan T L Nisperos B | 1994 | Int J Cancer1994，56，4： | 1 |
| 13 | Irrigation performance measures: efficiency and uniformity显示文摘 | Burt C M Clemmens A J Strelkoff T S | 1997 | Journal of Irrigation and Drainage Engineering ASCE1997，123，6： | 1 |
| 14 | The vertical component of a fish's spatial map显示文摘 | BURT de PERERA T de VOS A GUILFORD T | 2005 | Anim Behav2005，70，2： | 1 |
| 15 | 1998, A univariate model of river water nitrate time series 显示文摘 | Worrall F Burt T P | 1998 | Journal of Hydrology1998，214，： | 1 |
| 16 | Synoptic climatology of air pollution in Moscow显示文摘 | SHAHGEDANOVA M BURT T P DAVIES T D | 1998 | The or Appl Climatol1998，61，： | 1 |
| 17 | The laplacian pyramid as a compact image code显示文摘 | Burt P T Adelson E H | 1983 | IEEE Transactions on Communication1983，31，4： | 1 |
| 18 | The Laplacian Pyramid as A Compact Image Code显示文摘 | Burt P T Andelson E H | | 0，，： | 1 |
| 19 | Comparing the immunogenicity of glycosidase-directed resiquimod prodrugs mediated by cancer cell metabolism显示文摘We have recently developed an enzyme-directed immunostimulant(EDI)prodrug motif,which is metabolized to active immunostimulant by cancer cells and,following drug efflux,activates nearby immune cells,resulting in immunogenicity.In this study,we synthesized several EDI prodrugs featuring an imidazoquinoline immunostimulant resiquimod(a Toll-like receptor 7/8 agonist)covalently modified with glycosidase enzyme-directing groups selected from substrates of β-glucuronidase,α-mannosidase,or β-galactosidase.We compared the glycosidase-dependent immunogenicity elicited by each EDI in RAW-Blue macrophages following conversion to active immunostimulant by complementary glycosidase.At a cellular level,we examined EDI metabolism across three cancer cell lines(B16 melanoma,TC2 prostate,and 4T1 breast cancer).Comparing the relative immunogenicity elicited by each EDI/cancer cell combination,we found that B16 cells produced the highest EDI prodrug immunogenicity,achieving>95% of that elicited by unmodified resiquimod,followed by TC2 and 4T1 cells(40% and 30%,respectively).Immunogenicity elicited was comparable for a given cell type and independent of the glycosidase substrate in the EDIs or differences in functional glycosidase activity between cell lines.Measuring drug efflux of the immunostimulant payload and efflux protein expression revealed that EDI/cancer cell-mediated immunogenicity was governed by efflux potential of the cancer cells.We determined that,following EDI conversion,immunostimulant efflux occurred through both P-glycoprotein-dependent and P-glycoprotein-independent transport mechanisms.Overall,this study highlights the broad ability of EDIs to couple immunogenicity to the metabolism of many cancers that exhibit drug efflux and suggests that designing future generations of EDIs with immunostimulant payloads that are optimized for drug efflux could be particularly beneficial. | Austin T Ryan Anunay J Pulukuri Maryam Davaritouchaee Armina Abbasi Aaron T Hendricksen Larissa K Opp Anthony J Burt Amy E Nielsen Rock J Mancini | 2020 | Acta Pharmacologica Sinica2020，41，7： | 1 |
| 20 | The laplacian pyramid as a compact image code显示文摘 | BURT P T ADELSON E H | 1983 | IEEE Transaction on Communications1983，31，4： | 1 |
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