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| 1 | Structure and function of aggrecan显示文摘Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure (via its interaction with hyaluronan and link protein) that endows the cartilage with load-bearing properties. It is also crucial in chondroskeletal morphogenesis during development. Aggrecan is a multimodular molecule expressed by chondrocytes. Its core protein is composed of three globular domains (G1, G2, and G3) and a large extended region (CS) between G2 and G3 for glycosaminoglycan chain attachment. G1 comprises the amino terminus of the core protein. This domain has the same structural motif as link protein. Functionally, the G1 domain interacts with hyaluronan acid and link protein, forming stable ternary complexes in the extracellular matrix. G2 is homologous to the tandem repeats of G1 and of link protein and is involved in product processing. G3 makes up the carboxyl terminus of the core protein. It enhances glycosaminoglycan modification and product secretion. Aggrecan plays an important role in mediating chondrocyte-chondrocyte and chondrocyte-matrix interactions through its ability to bind hyaluronan. | CHRIS KIANI, LIWEN CHEN, YAO JIONG WU, ALBERT J YEE, BURTON B YANG, Sunnybrook and Women’s College Health Sciences Centre and Department of Laboratory Medicine and Patobiology, 2 Department of Surgeny, Faculty of Medicine, University of Toronto, Canada | 2002 | Cell Research2002，12，1： | 27 |
| 2 | Friend or foe: the role of microRNA in chemotherapy resistance显示文摘 | Haoran LI Burton B YANG | 2013 | Acta Pharmacologica Sinica2013，34，7： | 12 |
| 3 | The CELLULOSE-SYNTHASE LIKE C (CSLC) Family of Barley Includes Members that Are Integral Membrane Proteins Targeted to the Plasma Membrane显示文摘纤维素象 SYNTHASE 一样 C (CSLC ) 家庭是在被认为在苔藓和脉管的植物的分叉前产生了的 CELLULOSE SYNTHASE/CELLULOSE 象 SYNTHASE 一样(CESA/CSL ) 多糖 synthase 总科以内的一个古老的系。作为在 flowering 植物的研究, Arabidopsis 建议了合成( 1,4 )-- xyloglucan ( XyG )的 glucan 脊梁,,拴住邻近的纤维素 microfibrils 到对方的墙多糖为 CSLC 的可能的功能, CSLC 功能在大麦( Hordeum vulgare L.)被调查,有在它的墙中的 XyG 的低数量的种。四大麦 CSLC 基因被识别(指明的 HvCSLC14 ) 。种系发生的分析在 flowering 植物揭示 CSLC 的三很好支持的 clades,与有在二这些 clades 的代表的大麦。四大麦 CSLC 在各种各样的纸巾被表示,与,包括有主要、第二等的房间墙的房间在在所有房间检测抄本的 situ PCR coleoptile 和根打字。合作表示分析证明 HvCSLC3 并列地与通常认为的 XyG xylosyltransferase 基因被表示。两免疫 -- 他们和膜分别证明 HvCSLC2 位于大麦的血浆膜暂停有教养的房间并且不在象 endoplasmic 那样的内部膜蜂窝胃或 Golgi 仪器。基于我们多糖合成的亚 cellular 地点的当前的知识,我们断定 CSLC 家庭可能包含多糖 synthase 的超过一种类型。 | Fenny M. Dwivany Dina Yulia Rachel A, Burton Neil J. Shirley Sarah M. Wilson Geoffrey B, Fincher Antony Bacic Ed Newbigin Monika S. Doblin | 2009 | Molecular Plant2009，2，5： | 2 |
| 4 | Anticancer activity of Hemsleya am-abilis extract显示文摘 | Wu J Wu Y J Burton B Y | 2002 | Life Sciences2002，71，： | 1 |
| 5 | Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasis显示文摘 | BJORNDAHL M A CAO R BURTON J B | 2005 | Cancer Res2005，65，20： | 1 |
| 6 | Follow-up of patients with short-chain acyl-CoA dehydrogenase and isobutyryl- CoA dehydrogenase deficiencies identified through newborn screening: one center's experience 显示文摘 | Pena L Angle B Burton B | 2012 | Genet Med2012，14，3： | 1 |
| 7 | In vitro eytocidal effect of novel lyric peptides on plasmodium faleiparum and trypanosom a cruzfi显示文摘 | JAYNES J M BURTON C A BARR S B | 1989 | The FASEB Journal1989，2，12： | 1 |
| 8 | Transforming growth factor-beta-induced transcription of the Alzheimer beta-amyloid precursor protein gene involves interaction between the CTCF-complex and Smads显示文摘 | Burton T Liang B Dibrov A | 2002 | Biochem Biophys Res Commun2002，295，3： | 1 |
| 9 | Expanding the role of the stroke nurse: a , pragmatic clinical trial显示文摘 | Burton C Gibbon B | 2005 | J Adv Nurs2005，52，6： | 1 |
| 10 | Snail promotes cell migration through PI3K/AKT-dependent Racl activation as well as PI3K/ AKT-independent pathways during prostate cancer progression显示文摘 | Henderson V Smith B Burton LJ | 2015 | Cell Adh Migr2015，9，4： | 1 |
| 11 | Starch granule initiation and growth are altered in barly mutant that lack isoamylase activity显示文摘 | Jenner H Carrangis L Fahy B Fincher G B Hylton C Laurie D A Parker M Waite D Wagen S V Verhoeven T Denyer K | 2002 | The Plant Journal2002，31，1： | 1 |
| 12 | Space/time trade-offs in hash coding with allowable errors显示文摘 | BURTON H B | 1970 | Communications of the ACM1970，13，7： | 1 |
| 13 | 显示文摘 | Burton B P Cockayne E | 1999 | Physical Review B1999，60，12： | 1 |
| 14 | Texture Orientation and Anisotropy Calculation by Fourier Transform and Principal Component Analysis显示文摘 | Josso B Burton D R Lalor M J | 2005 | Mechanical Systems and Signal Processing2005，19，5： | 1 |
| 15 | Evidence for involvement of cyclic GMP phosphodiesterase in morphine tolerance 显示文摘 | Burton C K Ho I K Hoskins B | 1990 | J Pharmacol Exp Ther1990，252，1： | 1 |
| 16 | The Role of Bcl-2 Family Member Bnip3 in Cell Death and Disease: Nipping at the Heels of Cell Death显示文摘 | Burton T R Gibson S B | 2009 | Cell Death Differ2009，16，4： | 1 |
| 17 | An increased incidence of haemangiomas in infants born following chorionic villus sampling (CVS)显示文摘 | BURTON B K SCHULZ C J ANGLE B | 1995 | Prenat Diagn1995，15，3： | 1 |
| 18 | The human first trimester gestational sac limits rather facilitates oxygen transfer to the foetus-a review显示文摘 | JAUNIAUX E GULBIS B BURTON G J | | 0，，： | 1 |
| 19 | Evaluating a systemat- ic voiding programme for patients with urinary incontinence after stroke in secondary care using soft systems analysis and Normalisation Process Theory: findings from the ICONS case study phase显示文摘 | Thomas LH French B Burton CR | 2014 | IntJ Nurs Stud2014，51，10： | 1 |
| 20 | Root morphology and vigor effects on winter heading of established alfalfa显示文摘 | Perfect E Miller R D Burton B | 1987 | Agronomy Journal1987，79，6： | 1 |
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