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	题名	作者	年代	出处	被引量
1	4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells.	Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon	2017	Cellular & Molecular Immunology2017，14，9：	6
2	Experimental study on natural convection heat transfer from horizontal cylinders with longitudinal plate fins 显示文摘	HYUN J K BYOUNG H A JINIL P	2013	Mechanical Science and Technology2013，27，2：	1
3	Characteristics of HVOF-sprayed WC-Co cermet coatings affected by WC particle size and fuel/oxygen ratio显示文摘	Byoung K H Suhr D S	2001	Materials Transactions2001，42，5：	1
4	Automatic Federate Adjustment for Pocket Maching 显示文摘	Seok-Hyung B Keyhoon K Kim B H Byoung K C	2003	Computer-Aided Design2003，35，：	1
5	FSA-Based link assignment and routing in low-earth orbit satellite networks 显示文摘	Hong S C Byoung W K Chang G L	1998	IEEE Transactions on Vehicular Technology1998，47，3：	1
6	C-space approach to tool-path generation for die and mould machining 显示文摘	Choi Byoung K Kim Dae H Jerard Robert B	1997	Computer-Aided Design1997，29，9：	1
7	Fire detection based on vision sensor and support vector machines显示文摘	BYOUNG C K CHEONG K H NAM J Y		0，，01：	1
8	Cross-resistance Between Rifampicin and Rifabutin and Its Relationship with rpoB Gene Mutations in Clinically Isolated MDR-TB Strains 显示文摘	Byoung K Seung O Eun C Seung P	2006	Tuberc Respir Dis2006，60，2：	1
9	Application of neural network to the supervisory control of a reheating furnace in the steel industry显示文摘	Young I K Ki C M Byoung S K	1998	Control Engineering Practice1998，6，：	1
10	A new technology for preparation of PDMS pervaporation显示文摘	Hee J K Sung S N Byoung R M	2002	Advance in Environmental Research2002，6，：	1
11	UV curable polyurethane dispersions from polyisocyanate and organosilane显示文摘	BYOUNG U A SU K L SANG K L	2008	Progress in Organic Coatings2008，62，：	1
12	Effects of ceramic fillers on the electrical properties of (PEO)16LiClO4 electrolytes显示文摘	Young W K Kyoun H S	1997	J Power Sources1997，68，：	1
13	Surface properties offluorinated single-walled carbon nanotubes显示文摘	Young S L Tae H C Byoung K L	2003	Journal of Fluo-rine Chemistry2003，120，2：	1
14	Discrimination of Korean Rehmannia glutinosa from Chinese Rehmannia glutinosausing sequence-char- acterized amplified region marker 显示文摘	Young S K Jin A R Byoung S K	2012	Korean Soc Appl Biol Chem2012，55，：	1
15	HumanCentered Virtual Manufacturing Systems for Next Generation Manufacturing显示文摘	Choi Byoung K Kim Byoung H	1999	VMS1999，，1：	1
16	Preparation and Characterization of MgO-CeOz Mixed Oxide Catalysts by Modified Coprecipitation Using Ionic Liquids for Dimethyl Carbonate Synthesis显示文摘	HAZNAN A BYOUNG S A CHANG S K	2007	Industrial Engineering Chemistry Research2007，46，：	1
17	Optical frequency-domain reflectometry based on wavelength-swept mode-locked fiber laser显示文摘	MYOUNG S O HEE S P BYOUNG Y K	2003	IEEE Photonics Technology Letters2003，15，2：	1
18	Application of Neural Network to the Supervisory Control of a Reheating Furnace in the Steel Industry显示文摘	Young I K Ki C M Byoung S K	1998	Control Engineering Practice1998，6，：	1
19	Wear performance of the Fe-based alloy coatings produced by plasma transferred arc weld-surfacing process 显示文摘	Hyung J K Byoung H Y Chang H L	2002	Wear2002，249，78：	1
20	Time-domain reflection field analysis for ultrasonic evaluation of thin layered media显示文摘	Byoung G K Sekyung L Kishi T	1996	NDT&E International1996，29，5：	1

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