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| 1 | Response to endoscopic therapy for biliary anastomotic strictures in deceased versus living donor liver transplantation显示文摘BACKGROUND:Endoscopic therapy has been successful in the management of biliary complications after both deceased donor liver transplantation(DDLT) and living donor liver transplantation(LDLT).LDLT is thought to be associated with higher rates of biliary complications,but there are few studies comparing the success of endoscopic management of anastomotic strictures between the two groups.This study aims to compare our experience in the endoscopic management of anastomotic strictures in DDLT versus LDLT.METHODS:This is a retrospective database review of all liver transplant patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) after liver transplantation.The frequency of anastomotic stricture and the time to develop and to resolve anastomotic stricture were compared between DDLT and LDLT.The response of anastomotic stricture to endoscopic therapy was also analyzed.RESULTS:A total of 362 patients underwent liver transplantation between 2003 and 2011,with 125 requiring ERCP to manage biliary complications.Thirty-three(9.9%) cases of DDLT and 8(27.6%) of LDLT(P=0.01) were found to have anastomotic stricture.When comparing DDLT and LDLT,there was no difference in the mean time to the development of anastomotic strictures(98±17 vs 172±65 days,P=0.11),likelihood of response to ERCP [22(66.7%) vs 6(75.0%),P=0.69],mean time to the resolution of anastomotic strictures(268±77 vs 125±37 days,P=0.34),and the number of ERCPs required to achieve resolution(3.9±0.4 vs 4.7±0.9,P=0.38).CONCLUSIONS:Endoscopic therapy is effective in the majority of biliary complications relating to liver transplantation.Anastomotic strictures occur more frequently in LDLT compared with DDLT,with equivalent endoscopic treatment response and outcomes for both groups. | Calvin HY Chan Fergal Donnellan Michael F Byrne Alan Coss Mazhar Haque Holly Wiesenger Charles H Scudamore Urs P Steinbrecher Alan A Weiss Eric M Yoshida | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 7 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | Kinetics of allergen-induced airway eosinophilic cytokine production and airway inflammation显示文摘 | GAUVREAU G M WATSON R M O'BYRNE P M | 1999 | Am J Respir Crit Care Med1999，160，2： | 1 |
| 4 | Soil parameters for deformation analysis of sand masses显示文摘 | Cheung H Yan L | 1987 | Canadian Geotechnical Journal1987，24，： | 1 |
| 5 | The role of the supplementary motor area in externally timed movement: the influence of predictability of movement timing显示文摘 | Thiekbroom GW Byrnes ML Saeeo P | 2000 | Brain Res2000，874，： | 1 |
| 6 | Seismic Response and Liq- uefaction of Sands显示文摘 | Finn W D Byrne P M Martin G R | 1976 | Journal 05 Geotechnical Engineering Di vision ASCE1976，102，8： | 1 |
| 7 | Temperature, but not pH, compromises sea urchin fertilization and early development under near-futurc climate change scenarios 显示文摘 | Byrne M Ho M Selvakumaraswamy P | 2009 | Proceedings of the Royal Society B : Biological Sciences2009，276，： | 1 |
| 8 | The laser drilling of multi-layer aerospace material systems显示文摘 | A Corcoran L Sexton B Seaman P Ryan G Byrne | 2002 | Journal of Materials Processing Tech2002，，1： | 1 |
| 9 | Evaluation of a three- dimensional method of slope stability analysis 显示文摘 | Hungr O Salgado F M Byrne P M | 1989 | Canadian Geotechnical Journal1989，26，： | 1 |
| 10 | Frequency selectivity, multistability, and oscillations emerge from models ofgenetic regulatory systems显示文摘 | SMOLEN P BAXTER D A BYRNE J H | 1998 | Amer J Phys1998，274，： | 1 |
| 11 | Quality Assurance of computed and digital radiography systems显示文摘 | Walsh C Gorman D Byrne P | 2008 | Radiation Protection Dosimetry2008，128，4： | 1 |
| 12 | Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate显示文摘 | Zhou P Byrne C Jacobs J | 1995 | Genes Dev1995，9，： | 1 |
| 13 | Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52)显示文摘 | Byrne J A Mattie M G Basset P | 1996 | Genomics1996，35，3： | 1 |
| 14 | Virtual laryngoscopy--preliminary experience显示文摘 | Byrne AT Walshe P McShane D | 2005 | Eur J Radiol2005，56，1： | 1 |
| 15 | Urinary pro- teases degrade albumin: implications for measurement of albuminuria in stored samples 显示文摘 | Kania K Byrnes EA Beilby J P | 2010 | Ann Clin Bio- chem2010，47，2： | 1 |
| 16 | Systemic disease involving an iridovirus-like agent in cultured tilapia,Oreochromis niloticus显示文摘 | McGrogan D G Ostland V E Byrne P J | 1998 | Journal of Fish Diseases1998，21，2： | 1 |
| 17 | The Efficacy and Loss of Fertilizer N in Lowland Rice 显示文摘 | VLEK P L G BYRNES B H | 1986 | Fetilizer Research1986，9，12： | 1 |
| 18 | Conditionals:A Theory of Meaning,Pragmatics,and Inference显示文摘 | BYRNE M J | 2002 | PsychologicalReview2002，109，4： | 1 |
| 19 | Increasing doses of inhaled corticosteroids compared to adding long-acting inhaled β2-agonists in achieving asthma control显示文摘 | Paul M O'Byrne Ian P | 2008 | Chest2008，134，： | 1 |
| 20 | Evaluation of a three dimensional method of slope-stability analysis显示文摘 | HUNGR O SALGADO F M BYRNE P M | 1989 | Canadian Geoteehnieal Journal1989，26，： | 1 |
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