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| 1 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020,26,34: | 5 |
| 2 | A crit- ical study of selected classification algorithms for Liver Disease Diagnosis 显示文摘 | Bendi V R Pmsad Babu M S Venkateswarlu N B | 2011 | International Journal of Database Management Systems(UDMS)2011,3,2: | 1 |
| 3 | Adventitial gene transfer of VEGFR-2 specific VEGF-E chimera induces MCP-1 expression in vascular smooth muscle cells and enhances neointimal formation显示文摘 | Bhardwaj S Roy H Babu M | 2011 | Atherosclerosis2011,219,1: | 1 |
| 4 | Integrating marker-assis- ted selection in crop breeding-prospects and challenges 显示文摘 | Babu R Nair S K Prasanna B M | 2004 | Cur- int Sci2004,87,: | 1 |
| 5 | Liquid-liquid extraction of brornelain and polyphenol oxidase using aqueous two-phase system显示文摘 | RAV1NDRA BABU B RASTOGI N K RAGHAVARAO K S M S | 2008 | Chemical Engineering and Processing2008,47,1: | 1 |
| 6 | An Efficient and Cost-effective Synthesis of 3-ethoxy-4-ethoxycarbonyl-phenylacetic Acid:A Key Acid Synthon of Repaglinide 显示文摘 | SALMAN M BABU S | 2002 | Organic Process Research & Development2002,6,: | 1 |
| 7 | A triphasic ceramic- coated porous bydroxyapatite for tissue engineering application 显示文摘 | Nair M B Suresh Babu S Varma H K | 2008 | Acta Biomater2008,4,1: | 1 |
| 8 | Liquid - liquid extraction of bromelain and polyphenol oxidase using aqueous two- phase system显示文摘 | Babu B R Rastogi N K Raghavarao K S M S | 2008 | Chemical Engineering and Processing2008,47,1: | 1 |
| 9 | Cerium (III)chloride promoted highly regioselective ring opening of ep-oxides and aziridines using NaN3 in acetonitrile : a facilesynthesis of 1,2-azidoaicohols and 1,2-azidoamines 显示文摘 | Sabitha G Babu R S Rajkumar M | 2002 | Org Lett2002,4,3: | 1 |
| 10 | Adventitial gene transfer of VEGFR-2 specific VEGF-E chimera induces MCP-1 expression in vascular smooth muscle cells and enhances neointimal formation显示文摘 | Bhardwaj S Roy H Babu M | 2011 | Atherosclerosis2011,219,123: | 1 |
| 11 | Cataract surgery in patients with Vogt - Koyanagi - Harada syndrome 显示文摘 | GANESH S K PADMAJA M S BABU K | 2004 | J Cata- ract Refract Surg2004,30,1: | 1 |
| 12 | Association of interleukin-10 gene promoter poIy- morphism in allergic patients显示文摘 | GADDAM S L PRIYA V H S BABU B M V S | 2012 | Genet Test Mol Bi- omarkers2012,16,: | 1 |
| 13 | Biology, ecology, silviculture and potential uses of Eucalyptus: An overview显示文摘 | Kandasamy O S Yassin M M Babu R C | 2000 | Journal of Medicinal and Aromatic Plant Sciences2000,22,18: | 1 |
| 14 | Microstructural evaluation of melt conditioned twin roll cast A1-Mg alloy显示文摘 | KUMAR S HARI BABU N SCAMANS G M FAN Z | 2011 | Materials Science and Technology2011,27,12: | 1 |
| 15 | Characterization of the mierostructure evolution in a nickel base superalloy during continuous cooling conditions 显示文摘 | Babu S S Miller M K Vitek J M | 2001 | Aeta Materialia2001,49,20: | 1 |
| 16 | Possible role of neonatal infection with the asymptomatic reassortant rotavirus (RV) strain I321 in the decrease in hospital admissions for RV diarrhea,Bangalore,India,1988-1999显示文摘 | Vethanayagam R R Ananda Babu M Nagalaxmi K S | 2004 | J Infect Dis2004,189,12: | 1 |
| 17 | Tumornecrosisfactoralpha(TNFGα)autoregulatesitsexpresGsionandinducesadhesionmoleculeexpressioninasthma显示文摘 | BABUS K PUDDICOMBE S M ARSHAD H H etal | 2011 | ClinImmunol2011,140,: | 1 |
| 18 | Effect of 30 T magnetic field on transformations in a novel bainitic steel显示文摘 | JaramiUo R A Babu S S Ludtka G M | 2006 | Scripta Materials2006,52,: | 1 |
| 19 | Atomic scale observations of bainite transformation in a high carbon high silicon steel 显示文摘 | Caballero F G Miller M K Babu S S | 2007 | Acta Materialia2007,55,1: | 1 |
| 20 | Collision Free Path Planning of Cooperative Crane Manipulators Using Genetic Algorithm显示文摘 | Deen Ali Ajmal M S Babu | 2005 | Journal of Computing in Civil Engineering2005,19,2: | 1 |