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| 1 | Epigenetic basis of hepatocellular carcinoma: A network-based integrative meta-analysis显示文摘AIM To identify the key epigenetically modulated genes and pathways in HCC by performing an integrative meta-analysis of all major, well-annotated and publicly available methylation datasets using tools of network analysis.METHODS Pub Med and Gene Expression Omnibus were searched for genome-wide DNA methylation datasets. Patient clinical and demographic characteristics were obtained. DNA methylation data were integrated using the Ingenuity Pathway Analysis, a software package for visualizing and analyzing biological networks. Pathway enrichment analysis was performed using IPA, which also provides literature-driven and computationallypredicted annotations for significant association of genes to curated molecular pathways.RESULTS From an initial 928 potential abstracts, we identified and analyzed 11 eligible high-throughput methylation datasets representing 354 patients. A significant proportion of studies did not provide concomitant clinical data. In the promoter region, HIST1H2AJ and SPDYA were the most commonly methylated, whereas HRNBP3 gene was the most commonly hypomethylated. ESR1 and ERK were central genes in the principal networks. The pathways most associated with the frequently methylated genes were G-protein coupled receptor and c AMP-mediated signalling. CONCLUSION Using an integrative network-based analysis approach of genome-wide DNA methylation data of both the promoter and body of genes, we identified G-protein coupled receptor signalling as the most highly associated with HCC. This encompasses a diverse range of cancer pathways, such as the PI3 K/Akt/m TOR and Ras/Raf/MAPK pathways, and is therefore supportive of previous literature on gene expression in HCC. However, there are novel targetable genes such as HIST1H2 AJ that are epigenetically modified, suggesting their potential as biomarkers and for therapeutic targeting of the HCC epigenome. | Venkat Bhat Sujitha Srinathan Elisa Pasini Marc Angeli Emily Chen Cristina Baciu Mamatha Bhat | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 2 | Extreme methane deuterium, nitrogen and helium enrichment in natural gas from the Homorod seep (Romania) 显示文摘 | Etiope G Baciu C L Schoell M | 2011 | Chemical Geology2011，280，1： | 1 |
| 3 | Hypothalarnic mechanisms of immunity显示文摘 | Baciu I Hriscu M Saulea G | 2003 | Int J Neurosci2003，113，2： | 1 |
| 4 | Methane emission from natural gas seeps and mud volcanoes in Transylvania (Romania) 显示文摘 | Spulber L Etiope G Baciu C | 2010 | Geofluids2010，10，1： | 1 |
| 5 | Image-based template generation of road networks for virtual maps 显示文摘 | Sun J Baciu G Yu X B | 2004 | International Journal of Image and Graphics2004，4，4： | 1 |
| 6 | Image-based collision detection for deformable cloth models 显示文摘 | Baciu G Wong W S -K | 2004 | IEEE Transactions on Visualization and Computer Graphics2004，10，6： | 1 |
| 7 | Central processing of rectal pain in patients with irritable bowel syndrome:an fMRI study显示文摘 | Bonaz B Baciu M Papillon E | 2002 | Am J Gastroenterol2002，97，3： | 1 |
| 8 | Retinal Pigment Epithelial Cell Death by the Alternative Complement Cascade: Role of Membrane Regulatory Proteins, Calcium, PKC and Oxidative Stress 显示文摘 | Yang P Baciu P Parker KB | 2014 | Invest Ophthalmol Vis Sci2014，55，5： | 1 |
| 9 | High glucose concentrations increase the tumor necrosis factor-alpha production capacity by human pe- ripheral blood mononuclear cells 显示文摘 | Hancu N Netea MG Baciu I | 1998 | Rom J Physiol1998，35，34： | 1 |
| 10 | No- nconvex sparse regularizer based speckle noise removal显示文摘 | Yu Han Xiang-Chu Feng George Baciu Wei-Wei Wang | 2013 | Pattern Recognition2013，46，3： | 1 |
| 11 | Variational and PCA based natural image segmentation 显示文摘 | Han Y Feng X C Baciu G | 2013 | Pattern Recognition2013，46，1： | 1 |
| 12 | Image-based techniques in a hybrid collision detector显示文摘 | Baciu G Wong W S K | 2003 | IEEE Transactions on Visualization and Computer Graphics2003，9，2： | 1 |
| 13 | Aspects concerning the perlite recovery in addition with polymeric additives for constructionsmaterials显示文摘 | Fiat D Lazar M Baciu V | 2010 | Materiale Plastice2010，47，1： | 1 |
| 14 | Recode: An Image - Based Collision Detection Algorithm显示文摘 | Baciu G Wong S Sun H | 1999 | Journal of Visualization and Computer Animation1999，10，4： | 1 |
| 15 | Image- based techniques in a hybrid collision detector 显示文摘 | Baciu G Wong S K | 2003 | IEEE Transactions on Visualization and Computer Graphics2003，15，6： | 1 |
| 16 | Equivalence between LDA/QR and direct LDA显示文摘 | Li Ronghua Liang Shuang Baciu George | 2011 | International Journal of Cognitive Informatics and Natural Intelligence2011，5，1： | 1 |
| 17 | Entropy-based motion extraction for motion capture animation显示文摘 | So Clifford K F Baciu George | 2005 | Computer Animation and Virtual Worlds2005，16，3： | 1 |
| 18 | Direct virtual-hand interface in robot assembly programming显示文摘 | SUN Hanqiu YUAN Xiaobu BACIU G | 1999 | Journal of Visual Languages and Computing1999，，10： | 1 |
| 19 | Categorical and coordinate spatial rela- tions: fMRI evidence for hemispheric specialization 显示文摘 | Baciu M Koenig O | 1999 | Neu- roreport1999，10，6： | 1 |
| 20 | Nonconvex sparse regularIzer based speckle noise removal 显示文摘 | Han Yu Feng Xianghu George Baciu | 2013 | Pattern Recogni- tion2013，46，3： | 1 |
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