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| 1 | Transcatheter embolization therapy in liver cancer:an update of clinical evidences显示文摘Transarterial chemoembolization(TACE) is a form of intra-arterial catheter-based chemotherapy that selectively delivers high doses of cytotoxic drug to the tumor bed combining with the effect of ischemic necrosis induced by arterial embolization.Chemoembolization and radioembolization are at the core of the treatment of liver hepatocellular carcinoma(HCC) patients who cannot receive potentially curative therapies such as transplantation,resection or percutaneous ablation.TACE for liver cancer has been proven to be useful in local tumor control,to prevent tumor progression,prolong patients' life and control patient symptoms.Recent evidence showed in patients with single-nodule HCC of 3 cm or smaller without vascular invasion,the5-year overall survival(OS) with TACE was similar to that with hepatic resection and radiofrequency ablation.Although being used for decades,Lipiodol~(Lipiodol~ Ultra Fluid~,Guerbet,France) remains important as a tumor-seeking and radio-opaque drug delivery vector in interventional oncology.There have been efforts to improve the delivery of chemotherapeutic agents to tumors.Drug-eluting bead(DEB) is a relatively novel drug delivery embolization system which allows for fixed dosing and the ability to release the anticancer agents in a sustained manner.Three DEBs are available,i.e.,Tandem~(CeloNova Biosciences Inc.,USA),DC-Beads~(BTG,UK) and HepaSphere~(BioSphere Medical,Inc.,USA).Transarterial radioembolization(TARE) technique has been developed,and proven to be efficient and safe in advanced liver cancers and those with vascular complications.Two types of radioembolization microspheres are available i.e.,SIR-Spheres~(Sirtex Medical Limited,Australia) and TheraSphere~(BTG,UK).This review describes the basic procedure of TACE,properties and efficacy of some chemoembolization systems and radioembolization agents which are commercially available and/or currendy under clinical evaluation.The key clinical trials of transcatheter arterial therapy for liver cancer are summarized. | Yi-Xiang J.Wang Thierry De Baere Jean-Marc Idee Sebastien Ballet | 2015 | Chinese Journal of Cancer Research2015，27，2： | 72 |
| 2 | Adipose-derived mesenchymal stromal/stem cells: An update on their phenotype in vivo and in vitro显示文摘Adipose tissue is a rich, ubiquitous and easily acces-sible source for multipotent stromal/stem cells and has, therefore, several advantages compared to other sourc-es of mesenchymal stromal/stem cells. Several studies have tried to identify the origin of the stromal/stem cell population within adipose tissue in situ. This is a complicated attempt because no marker has currently been described which unambiguously identifies native adipose-derived stromal/stem cells(ASCs). Isolated and cultured ASCs are a non-uniform preparation consisting of several subsets of stem and precursor cells. Cultured ASCs are characterized by their expression of a panel of markers(and the absence of others), whereas their in vitro phenotype is dynamic. Some markers were ex-pressed de novo during culture, the expression of some markers is lost. For a long time, CD34 expression was solely used to characterize haematopoietic stem and progenitor cells, but now it has become evident that it is also a potential marker to identify an ASC subpopula-tion in situ and after a short culture time. Nevertheless, long-term cultured ASCs do not express CD34, perhaps due to the artificial environment. This review gives an update of the recently published data on the origin and phenotype of ASCs both in vivo and in vitro. In addition, the composition of ASCs(or their subpopula-tions) seems to vary between different laboratories andpreparations. This heterogeneity of ASC preparationsmay result from different reasons. One of the main problems in comparing results from different laborato-ries is the lack of a standardized isolation and culture protocol for ASCs. Since many aspects of ASCs, suchas the differential potential or the current use in clinical trials, are fully described in other recent reviews, this review further updates the more basic research issues concerning ASCs' subpopulations, heterogeneity andculture standardization. | Patrick C Baer | 2014 | World Journal of Stem Cells2014，6，3： | 16 |
| 3 | 经皮射频消融术联合经皮肝静脉或门静脉阻断术治疗肝脏恶性肿瘤显示文摘目的前瞻性评价经皮射频消融术(radiofrequen-cy,RF)联合经皮暂时性球囊肝静脉或门静脉大分支阻断术治疗肝脏恶性肿瘤的可行性、有效性及并发症。 | T.de Baere F.Deschamps P.Briggs C.Dromain V.Boige L.Hechel-hammer 向贤宏 | 2008 | 国际医学放射学杂志2008，31，A06： | 9 |
| 4 | 门静脉栓塞术4种栓塞材料的对比:猪的实验性研究显示文摘对门静脉栓塞术(PVE)中不同栓塞材料进行评估。20只猪接受左、中PVE.按照栓塞材料分为4组,每组5只,栓塞材料分别为亲水磷酸胆碱、丁酰基氰基丙烯酸酯(NBCA)、亲水凝胶和聚乙烯醇(PVA)颗粒,后者大小50-150μm或700~900μm。在行PVE前、术后即刻及术后第7天行安乐死前对受试动物进行门静脉造影及门脉压力测定。获取楔形的栓塞组织和未栓塞的肝脏进行病理检查。在完全栓塞后7d。受试猪中应用亲水凝胶的1只和应用700~900μm PVA的1只. | T. de Baere A. Denys V. Paradis 郑昊宇(译) 刘筠(校) | 2009 | 国际医学放射学杂志2009，32，4： | 9 |
| 5 | Clinical practice of transarterial chemoembolization for hepatocellular carcinoma:consensus statement from an international expert panel of International Society of Multidisciplinary Interventional Oncology(ISMIO)显示文摘Importance:Transarterial chemoembolization(TACE)has been associated with a wide range of practice variations for hepatocellular carcinoma(HCC)between the East and the West.This considerable ambiguity may lead to the heterogeneous quality in treatment and have a negative impact on the role of TACE in the overall multidisciplinary HCC treatment system.Objective:It may be a good start to establish a guideline worldwide to have this consensus from experts who represent east and west,although it does not cover all aspects of TACE.Evidence Review:An international expert panel on TACE is convened to cluster the expert’s opinions and summary a standard consensus.This panel committee consist of leading physicians in TACE on HCC from USA,France,Japan,Singapore,Korea,China,and so on.The first-round face-to-face consensus meeting was held during in Nanjing,China in October 2019.The second-round conference for revision of the consensus was held during the Annual Meeting of Chinese College of Interventionalists in August 2020 by a hybrid format of a Webinar and roundtable meeting.After several on-line revisions,the final manuscript was approved by all members of the panel in June 2021.Findings:The consensus statements were organized into the following categories:patients’selection,performing the procedure,TACE outcomes,repeat TACE,TACE failure/refractory,and TACE-based combination treatments.Conclusions and Relevance for Reviews:More and more evidences have showed the better outcomes with strategy of combined TACE with other local therapies such as ablations.The most-recently developing strategy of combined TACE with PD-1/PD-L1 plus tyrosine kinase inhibitor(TKI)agents has shined a light to the HCC patients,especially to those with high risk of tumor recurrence after treatment or TACE failure/refractory. | Jian Lu Ming Zhao Yasuaki Arai Bin-Yan Zhong Hai-Dong Zhu Xiao-Long Qi Thierry de Baere Uei Pua Hyun Ki Yoon David C.Madoff Gao-Jun Teng International Society of Multidisciplinary Interventional Oncology(ISMIO) | 2021 | Hepatobiliary Surgery and Nutrition2021，10，5： | 9 |
| 6 | 初始场和长波辐射对气候模拟的影响显示文摘对CCM2 (T42L1 8)模式运行 1 0次 ,每次初始状态稍微变化。试验结果表明了CCM2模式对初始场的响应 ,1 0次运行长波辐射 (LWR)加热率的标准差在全球许多地方和谱的许多尺度上超过 1 0 %。相似的结果也可以从云和温度的计算结果中发现。从CCM 2算法的 1 0次运行和应用CCM 2、MOR和NMC三种不同的LWR算法的 3次运行的试验比较中发现 ,不同LWR算法模式运行之间的变率比没有LWR算法变化的初始场作用大得多。在CCM2模式中 ,比较应用CCM 2、MOR和NMC三种不同的LWR算法的气候模拟 ,我们发现CCM 2和MOR的算法比较接近 ,而和NMC的差别较大。但三种不同的LWR算法 3次运行积分结果的平均值和不同算法间的绝对差值在全球许多地方和不同尺度上的差别都超过 1 0 % ,远远大于初始场对气候模拟的作用。 | 沈元芳 F. Baer 王超 | 2003 | 应用气象学报2003，14，3： | 5 |
| 7 | 参与式管理解决冲突:遥感和GIS用作瑞典北部驯鹿业土地利用需求信息交流的工具显示文摘在解决复杂的土地管理问题时,对短缺或者有争执的资源进行地理评估有助于不同利益相关者之间沟通认识和增进理解。本文中,我们说明如何使用遥感和GIS收集和汇总瑞典北部驯鹿放牧者和其他土地使用者(林业、采矿业、旅游业等等)的土地使用活动及使用模式的信息。该项目主要基于最终的土地使用者,即驯鹿放牧者们所做的工作,体现了面向土地使用者的新的努力。发展驯鹿业的土地利用规划的基础有以下几个方面:收集并数字化传统的驯鹿栖息地生态学和景观信息;将这些信息与来自野外调查及基于人造卫星观测的植被分类结果整合;绘制其他土地使用者的活动情况图。最终的土地利用规划提供的信息有利于驯鹿放牧者与其他利益相关者之间的磋商,并有助于驯鹿管理实施。该项目可作为一种大众参与和计划编制的模式,从而使本土信息和先进的遥感技术融入一个交互式的过程中。 | Per Sandstrm Tina Granqvist Pahlén Lars Edenius Hans Tφmmervik Olle Hagner Leif Hemberg Hkan Olsson Karin Baer Thomas Stenlund Lars Gran Brandt Mikael Egberth 周立志 程利群 | 2003 | AMBIO-人类环境杂志2003，32，8： | 4 |
| 8 | 经导管动脉栓塞术治疗肝癌:最新临床证据显示文摘对不能接受根治性治疗如肝移植、肿瘤切除术或经皮射频消融术(radiofrequency ablation,RFA)的肝细胞肝癌(hepatocellular carcinoma,HCC)患者,经导管动脉化疗栓塞术(transarterial chemoembolization,TACE)或放疗栓塞术(transarterial radioembolization,TARE)是治疗的核心手段。近期研究证据显示:对于无血管侵犯、3 cm及以下单结节型HCC患者,TACE与肿瘤切除术及RFA后的5年总生存率相似。尽管已应用数十年,碘油(超液化碘油®,Lipiodol®Ultra Fluid,Guerbet,France)作为一种亲肿瘤性且不透射线的药物运输载体在肿瘤介入治疗中的地位依然重要。药物缓释微球(drug-eluting bead,DEB)是栓塞术中一种较新型的药物输送方式,既可维持药物浓度,也可持续释放抗癌药。现有三种DEB可供临床选择使用,即Tandem®(Celo Nova Biosciences Inc.),DC-Beads®(BTG,UK)和Hepa Sphere®(Bio Sphere Medical,Inc.,USA)。经动脉TARE已被证实可安全有效地运用于晚期肝癌及有肝血管侵犯的患者。两种放射性栓塞微粒可供临床选择使用,即SIR-Spheres®(Sirtex Medical Limited,Australia)和Thera Sphere®(BTG,UK)。本文总结肝癌经导管动脉治疗的关键临床试验。 | Yì-Xiáng J.Wáng Thierry De Baere Jean-Marc Idée Sébastien Ballet 邓敏 王毅翔 | 2015 | 临床与病理杂志2015，35，7： | 2 |
| 9 | 胰腺内分泌肿瘤:MRI哪些序列最有价值?显示文摘目的确定胰腺内分泌肿瘤(ETP)的MRI信号、强化特征及其显示病变的最佳序列。方法连续55例病人(68个ETP)行腹部1.5TMRI检查,序列包括T2WI序列。 | C.Caramella C Dromain T.De Baere B.Boulet M.Schlumberger M.Ducreux 程悦 | 2011 | 国际医学放射学杂志2011，，1： | 2 |
| 10 | 脑干躯体感觉系统的扩散张量纤维束成像:3.0T各向同性高空间分辨力成像表现的初探显示文摘由于既往无创性检查的敏感度及空间分辨力的不足,因此制约了对不同躯体感觉通路(内侧丘系和脊髓丘系)的显示。本研究采用各向同性高空间分辨力的扩散张量成像(DTI)和基于DTI的3D纤维束成像技术.探讨其是否可促进对健康成人脑干躯体感觉系统的解剖研究。5例健康男性(24~37岁)被纳入本研究,并获得知情同意。为对脑干内感觉传导通路进行描绘及定量分析.采用3.0TMR行高空间分辨力神经纤维连续追踪技术(FACT)的扩散张量纤维束成像(DTT), | T. de Baere A. Denys V. Paradis 郑昊宇(译) 刘筠(校) | 2009 | 国际医学放射学杂志2009，32，4： | 2 |
| 11 | Immunological aspects of recombinant adeno-associated virus delivery to the mammalian brain显示文摘 | Baer K Symes CW | 2002 | J Virol2002，76，16： | 1 |
| 12 | Analysis of the effect of a Rossby Wave on sound speed in the ocean显示文摘 | BAER R N JACOBSON M | 1974 | J Acoust Soc Am1974，55，6： | 1 |
| 13 | Hierarchical structure of the intervertebral disc显示文摘 | Cassidy JJ Hiltner A Baer E | 1989 | Connect Tissue Research1989，23，： | 1 |
| 14 | Single-frequency operation in solid-state laser materials with short absorption depths显示文摘 | Kintz G J Baer T | 1990 | IEEE Journal of Quantum Electronics1990，26，9： | 1 |
| 15 | Effective hardware-based data prefetching for high performance multiprocessors显示文摘 | Chen T F Baer J L | 1995 | IEEE Transactions on Computers1995，44，5： | 1 |
| 16 | Improving surface-analysis methods for characterization of advanced materials by development of standards, reference data, and interlaboratory comparisons 显示文摘 | Baer D R | 2007 | Suoeace and Interface Analysis2007，39，4： | 1 |
| 17 | The Brown Assessment of Be- liefs Scale: Reliability and validity显示文摘 | Eisen J L Phillips K A Baer L | 1998 | Am J Psychiatry1998，155，1： | 1 |
| 18 | Latent Class Analysis: A Method for Captu- ring Heterogeneity 显示文摘 | Rosato NS Baer JC | 2012 | Soc Work Res2012，36，1： | 1 |
| 19 | Reinforcement control of generalized imitation in young children 显示文摘 | Baer D M Sherman J A | 1964 | Journal of Experimental Child Psychology1964，1，1： | 1 |
| 20 | Surgically induced changes in corneal viscoelastic properties after 23-gauge pars plana vitrec- tomy using ocular response analyzer显示文摘 | Seymenolu G Uzun O Baer E | 2012 | Current Eye Research2012，38，1： | 1 |
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