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| 1 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 2 | Subtype-selective antagonists of lysophosphatidic acid receptors inhibit platelet activation triggered by the lipid core of atherosclerotic plaques显示文摘 | ROTHER E BRANDL R BAKER D L | 2003 | Circulation2003，108，6： | 2 |
| 3 | Comparison of reaction mechanism of epoxy resins undergoing thermal and microwave cure from insitu measurements of microwave dieltric properxties and infrared spectroscopy显示文摘 | Marand E Baker K R Graybeal J D | 1992 | Macromolecules1992，25，8： | 1 |
| 4 | Applications of chlorophyll fluorescence can improve crop production strategies: an examination of future possibilities 显示文摘 | Baker N R Rosenqvist E | 2004 | Journal of Experimental Botany2004，55，403： | 1 |
| 5 | The relationship be-tween the quantum yield of photosynthetic electron transportand quenching of chlorophyll fluorescence 显示文摘 | Genty B E Briantais M J Baker N R | 1989 | BiochemistryBiophysics Acta1989，990，： | 1 |
| 6 | The structure of glucose-fructose oxidoreductase from Zymomonas mobilis:an osmoprotective periplasmic enzyme containing non-dissociable NADP显示文摘 | KINGSTON R L SCOPES R K BAKER E N | 1996 | Structure1996，4，12： | 1 |
| 7 | Source apportionment of polycyclic aromatic hydrocarbons in the urban atmosphere:a comparison of three methods显示文摘 | Larsen R K Baker J E | 2003 | Environmental Science and Technology2003，37，9： | 1 |
| 8 | Autoradiographic study of the distribution and cellular uptake of ( ^14 C ) -streptozotocin in the rat 显示文摘 | KARUNANAYAKE E H BAKER J R CHRISTIAN R A | 1976 | Diabetologia1976，12，： | 1 |
| 9 | Debromination of polybrominated diphenyl ether congeners BDE 99 and BDE 183 in the intestinal tract of the common carp (Cyprinus car- pio) 显示文摘 | Stapleton H M Letcher R J Baker J E | 2004 | Environmental Science & Technology2004，38，4： | 1 |
| 10 | The effect of calcium on the fluidity and phase properties of microsomal membranes isolated from postclimacteric Golden Delicious apples显示文摘 | Legge R L Thompson J E Baker J E | 1982 | Plant and Cell Physiology1982，23，2： | 1 |
| 11 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 12 | Factors affecting Trichoderma hamatum applied to' seeds as a biocontrol agent显示文摘 | HARMAN G E CHET L BAKER R | 1981 | Phytopathology1981，71，6： | 1 |
| 13 | Creating something from nothing: Resource construction through entrepreneurial bricolage 显示文摘 | Baker T Nelson R E | 2005 | Administrative Science Quarterly2005，50，： | 1 |
| 14 | Tillage and soil carbon sequestration: what do we really know?显示文摘 | BAKER J M OCHSNER T E VENTEREA R T | 2007 | Agriculture Ecosystems & Environment2007，118，： | 1 |
| 15 | Subtype-selective an tagon is oflysophosphatidic Acid recep tors inhibit platelet activation triggered by thelipid core of atherosclerotic plaques显示文摘 | ROTHER E BRANDL R BAKER D L | 2003 | Circulation2003，108，3： | 1 |
| 16 | Tillage and soil carbon sequestration: What do we really know?显示文摘 | Baker J M Ochsner T E Venterea R T | 2007 | Agric Ecosyst Environ2007，118，14： | 1 |
| 17 | Subtype-selective antagonists of lysophosphatidic Acid receptors inhibit platelet activation triggered by the lipid core of atherosclerotic plaques 显示文摘 | Rother E Brandl R Baker DL | 2003 | Circulation2003，108，6： | 1 |
| 18 | Zinc ligands in the metal hyperaccumulation Thlaspi caerulescens as determined using X-ray absorption spectroscopy 显示文摘 | SALT D E PRINCE R C BAKER A J M | 1999 | Environmental Science & Technology1999，33，5： | 1 |
| 19 | Subtype-selective antagonists of lysophosphatidic Acid receptors inhibit platelet activation triggered by the lipid core of atherosclerotic plaques 显示文摘 | Rother E Brandl R Baker DL | 2003 | Circulation2003，108，6： | 1 |
| 20 | Reduction in natural death and failure from a systematic screening and treatment program in an Australian Aboriginal community 显示文摘 | Hoy W E Wang Z Baker P R et aI | 2003 | Kidney I nt Suppl2003，83，： | 1 |
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