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| 1 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 2 | The moderator-mediator vairable distinction in social psychological research:conceptual,strategic,and statistical considerations显示文摘 | BARON R M KENNY D A | 1986 | J Pers Soc Psychol1986，51，6： | 1 |
| 3 | The moderator - mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations 显示文摘 | Baron R M Kenny D A | 1986 | Journal of Personality and Social Psychology1986，51，： | 1 |
| 4 | The moderator-mediator variable distinction in social psychological research: Concep- tual, strategic, and statistical considerations 显示文摘 | Baron R M Kenny D A | 1986 | Journal of Personality and Social Psychology1986，51，6： | 1 |
| 5 | The moderator-mediator varia- ble distinction in social psychological research: Con- ceptual, strategic, and statistical considerations显示文摘 | Baron R M Kenny D A | 1986 | Journal of Personality and Social Psychology1986，51，6： | 1 |
| 6 | The Shang ring device for adult male circumcision: a proof of voncept study in Kenya显示文摘 | Barone M A Masson P Li P S | 2011 | J Acquir Immune DeficSyndr2011，57，1： | 1 |
| 7 | The Moderator-Mediator Variable Distinction in Social Psychological Research:Conceptual, Strategic ,and Statistical Considerations显示文摘 | Baron R M kenny D A | 1986 | Journal of Per- sonality and Social Psychology1986，51，6： | 1 |
| 8 | Opportunity recognition as the detection of meaningful patterns: Evidence from comparisons of novice and experienced entrepre- neurs显示文摘 | Baron R A Ensley M D | 2006 | Management Science2006，52，9： | 1 |
| 9 | The Moderator-mediator Variable Distinction in Social Psychological Research:Conceptual,Strategic,and Statistical Considerations显示文摘 | Baron R M David D A | 1986 | Journal of Personality and Social Psychology1986，51，6： | 1 |
| 10 | The moderator-mediator variable distinction in social psychological research: conceptual stragetic, and statistical considerations显示文摘 | BARON R M KENNY D A | 1986 | Journal of Personality and Social Psychology1986，51，6： | 1 |
| 11 | Hydrolysis and synthesis reactions catalysed by Thermomyces lanuginosa lipase in the AOT/Isooctane reversed micellar system 显示文摘 | Fernandes M L M Krieger N Baron A M | 2004 | J Mol Catal B : Enzym2004，30，1： | 1 |
| 12 | The Moderator Variable Distinction inSocial Psychological Research: Conceptual, Strategic, and StatisticalConsiderations 显示文摘 | BARON R M DAVID A K | 1999 | J Clin Psychy1999，60，9： | 1 |
| 13 | The Moderator - mediator Variable Distinction in Social Psychological Research:Conceptu- al, Strategic and Statistical Considerations显示文摘 | Baron R M Kenny D A | 1986 | Journal of Person- ality and Social Psychology1986，51，06： | 1 |
| 14 | The moderator-mediator variable distinc- tion in social psychological research: Conceptual, strategic, and sta- tistical considerations显示文摘 | Baron R M Kermy D A | 1986 | Journal of Personality and Social Psychol- ogy1986，51，6： | 1 |
| 15 | The moderator-mediator variable distinction in social psychological research Conceptual, strategic, and statistical considerations 显示文摘 | Baron R M Kenny D A | 1986 | Journal of Personality and Social Psychology1986，51，6： | 1 |
| 16 | The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations 显示文摘 | Baron R M Kenny D A | 1986 | Journal of Personality and Social Psychology1986，51，6： | 1 |
| 17 | The moderator-mediator variable distinction in social psychological research:conceptual,strategic,and statistical considerations显示文摘 | BARON R M KENNY D A | 1986 | Journal of Personality and Social Psychology1986，21，2： | 1 |
| 18 | Gastrointestinal adverse effects of short-term aspirin use:a meta-analysis of published randomized controlled trials显示文摘 | J A BARON S SENN M VOELLKER | 2013 | Drugs R D2013，13，1： | 1 |
| 19 | Treatment of severe chronic venous insufficiency using the subfascial endoscopic perforator vein procedure 显示文摘 | BARON H C WAYNE M G SANTIAGO C A | 2005 | Surg Endosc2005，19，1： | 1 |
| 20 | The Moderator-Mediator Variable Distinction in Social Psychological Research: Conceptual, Strategic and Statistical Considerations 显示文摘 | Baron R M Kenny D A | 1986 | Journal of Personality and Social Psychology1986，51，6： | 1 |
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