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| 1 | Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin,TGF-β1,IL-13 and oxidative stress显示文摘AIM To evaluate the therapeutic effects of bone marrowderived CD11b+CD14+ monocytes in a murine model of chronic liver damage. METHODS Chronic liver damage was induced in C57BL/6 mice by administration of carbon tetrachloride and ethanol for 6 mo. Bone marrow-derived monocytes isolated by immunomagnetic separation were used for therapy. The cell transplantation effects were evaluated by morphometry,biochemical assessment,immunohistochemistry and enzyme-linked immunosorbent assay. RESULTS CD11b+CD14+ monocyte therapy significantly reduced liver fibrosis and increased hepatic glutathione levels. Levels of pro-inflammatory cytokines,including tumor necrosis factor-α,interleukin(IL)-6 and IL-1β,in addition to pro-fibrotic factors,such as IL-13,transforming growth factor-β1 and tissue inhibitor of metalloproteinase-1 also decreased,while IL-10 and matrix metalloproteinase-9 increased in the monocytetreated group. CD11b+CD14+ monocyte transplantation caused significant changes in the hepatic expression of α-smooth muscle actin and osteopontin. CONCLUSION Monocyte therapy is capable of bringing about improvement of liver fibrosis by reducing oxidative stress and inflammation,as well as increasing antifibrogenic factors. | Veruska Cintia Alexandrino de Souza Thiago Almeida Pereira Valéria Wanderley Teixeira Helotonio Carvalho Maria Carolina Accioly Brelaz de Castro Carolline Guimaraes D’assuncao Andreia Ferreira de Barros Camila Lima Carvalho Virgínia Maria Barros de Lorena Vláudia Maria Assis Costa Alvaro Aguiar Coelho Teixeira Regina Celia Bressan Queiroz Figueiredo Sheilla Andrade de Oliveira | 2017 | World Journal of Gastroenterology2017，23，28： | 6 |
| 2 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 3 | Lower limb ischemia-reperfusion injury triggers a systemic inflammatory response and multiple organ dysfunction 显示文摘 | Yassin M M Harkin D W Barros D'Sa A A | 2002 | World JSurg2002，26，1： | 1 |
| 4 | Photosynthetic performance of two coffee species under drought显示文摘 | Matta F M D Maestri M Barros R S | 1998 | Photosyuthetica1998，，2： | 1 |
| 5 | Discretion and reputation in a model of monetary policy显示文摘 | Barro R J Gordon D R | 1983 | Journal of Monetary Economics1983，，12： | 1 |
| 6 | Rules discretion and reputation in a model of monetary policy显示文摘 | Barro R J Gordon D B | 1983 | Journal of Monetary Economics1983，，12： | 1 |
| 7 | Non-malignant central airway obstruction 显示文摘 | Barros Casas D FemOndez-Bussy S Folch E | 2014 | Arch Bronconeumol2014，50，8： | 1 |
| 8 | A positive theory of monetary policy in a national rate model显示文摘 | Barro R J Gordon D | 1983 | Journal of Monetary Economics1983，，19： | 1 |
| 9 | Cutaneous myiasis of the breast: mammographic and us features-report of five cases显示文摘 | de Barros N D'Avila MS de Pace Bauab S | 2001 | Radiology2001，218，2： | 1 |
| 10 | Dynamic grouping maintenance with time limited op- portunities 显示文摘 | VAN P D BARROS A B]RENGUER C | 2013 | Reliability Engineering and System Safety2013，120，： | 1 |
| 11 | Investigation of the genetic diversity of an invasive whitefly in China using both mitochondrial and nuclear DNA markers显示文摘 | Chu D Gao C S De Barro P J | 2011 | Bulletin of Entomological Research2011，101，： | 1 |
| 12 | The effect of RRA on the strength and SCC resistance on AA7050 and AA7150 aluminium alloys 显示文摘 | OLIVEIRA A F Jr de BARROS M C CARDOSO K R TRAVESSA D N | 2004 | Materials Science and Engineering A2004，379，12： | 1 |
| 13 | Design of a fuzzy controller in mobile robotics using genetic algorithms显示文摘 | M Mucientes D L Moreno S Barro | 2007 | Applied Soft Compu- ting2007，7，2： | 1 |
| 14 | Genetic algorithms applied to the selection of principal components显示文摘 | Barros A S Rutledge D N | 1998 | Chemometrics and intelligent laboratory systems1998，40，1： | 1 |
| 15 | Effects of the vitamin E in catalase activities in hippocampus after status epi- lepticus induced by pilocarpine in wistar rats显示文摘 | Barros D O Xavier S M L Barbosa C O etal | 2007 | Neuroscencei Letters2007，416，3： | 1 |
| 16 | Pulmonary involvement in ankylosing spondylitis显示文摘 | SAMPAIO - BARROS P D CERQUEIRA E M REZENDE S M | 2007 | Clin Rheumatol2007，26，2： | 1 |
| 17 | Frequency of 2,3,5 - triphenyltetrazolium chloride (TTC) non - reducing bacteria in pasteurized milk 显示文摘 | Beloti V BarroS M A F Freitas J C D | 1999 | Revista de Microbiologia1999，30，： | 1 |
| 18 | Lower limb ischemia-reperfusion injury triggers a systemic inflammatory response and mul-tiple organ dysfunction显示文摘 | Yassin MM Harkin DW Barros D'Sa AA | 2002 | World J Surg2002，26，1： | 1 |
| 19 | Description of the species of Eretmocerus Haldeman (Hymenoptera:Aphelinidae) parasitising Bemisia tabaci (Gennadius) ( Hemiptera: Aleyrodidae) and Trialeurodes vaporariorum ( Westwood) (Homoptera: Aleyrodidae) in Australia based on morphological and molecular data 显示文摘 | DE BARRO P J DRIVER F NAUMANN I D | 2000 | Austra J Entomol2000，39，： | 1 |
| 20 | Lower limb ischemia-reperfusion injury triggers a systemic inflammatory response and multiple organ dysfunction 显示文摘 | Yassin MM Harkin DW Barros D'Sa AA | 2002 | World J Surg2002，26，1： | 1 |
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