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| 1 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 2 | 难治性疼痛和高血压在急性B型主动脉夹层中的重要性:国际急性主动脉夹层登记的意见显示文摘急性B型主动脉夹层患者,可表现出对药物治疗无效的反复、难治性疼痛和(或)难治性高血压,当出现这些症状时有时可作为介入治疗的指征。研究者利用国际急性主动脉夹层登记(international registry of a-cute aortic dissection,IRAD)的资料调查难治性疼痛和(或)难治性高血压对急性B型主动脉夹层患者临床转归的影响。 | 张玲玉 叶鹏 Trimarchi S Eagle KA Nienaber CA Pyeritz RE Jonker FH Suzuki T O'Gara PT Hutchinson SJ Rampoldi V Grassi V Bossone E Muhs BE Evangelista A Tsai TT Froehlich JB Cooper JV Montgomery D Mein-hardt G Myrmel T Upchurch GR Sundt TM Issel-bacher EM | 2010 | 中华高血压杂志2010，18，12： | 4 |
| 3 | Surgical stress and cytoskeletal changes in lens epithelial cells following manual and femtosecond laser-assisted capsulotomy显示文摘AIM:To study the effect of mechanical stress on the cytoskeleton in lens epithelial cells following conventional phacoemulsification surgery(CPS)and femtosecond laserassisted cataract surgery(FLACS).METHODS:The cytoskeleton of the epithelial cells of the anterior lens capsules(ALC)removed by CPS and FLACS was examined by immunohistochemistry.Expression of the intermediate filament,glial fibrillary acidic protein(GFAP),and glutamine synthetase(GS)immunoreactivity were detected.In order to map the actin network of cells,fluorescently labeled phalloidin was used.The samples were examined using confocal laser scanning microscopy.RESULTS:GFAP expression was visible in a larger number of the epithelial cells after CPS compared to FLACS.In CPS sample’s epithelial cells,GFAP immunoreactivity indicated robust morphological change.Regarding the actin filaments,the presence of tubular elements connecting epithelial cells,regular actin pattern and marked cortical network after CPS were found.Following FLACS,the actin cytoskeleton of the epithelial cells remained densely structured,and the tubular elements were undetectable,however,the above-mentioned regular actin pattern and the marked cortical network were visible.CONCLUSION:The conventional removal of the ALC induces more robust changes of the cytoskeleton of the lens epithelial cells. | ANDrea Krisztina Sükosd Krisztina Szabadfi Edina Szabó-Meleg Beáta Gáspár Pavel Stodulka Gyorgy SétálóJr Róbert Gábriel Miklós Nyitrai Zsolt Biró Hajnalka Abrahám | 2020 | International Journal of Ophthalmology(English edition)2020，13，6： | 2 |
| 4 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 5 | Channel-mediated tonic GABArelease from glia显示文摘 | Lee S Yoon BE Berglund K | 2010 | Science2010，330，6005： | 1 |
| 6 | Managerial Shareownership, Voting Power, and Cash Dividend Policy显示文摘 | Eckbo BE Verma S | 1994 | Journal of Corporate Finance1994，1，1： | 1 |
| 7 | Outcome of second allogeneic transplants using reduced-intensity conditioning following relapse of haematological malignancy after an initial allogeneic transplant显示文摘 | Shaw BE Mufti GJ Mackinnon S | | 0，，12： | 1 |
| 8 | Ultralight- weight and flexible silylated nanocellulose sponges for the selective removal of oil from water 显示文摘 | ZHANG Z S BE G RENTSCH D | 2014 | Chem Ma- ter2014，26，8： | 1 |
| 9 | Effectiveness and Reliability of Selected Site Pacing for Avoidance of Phrenic Nerve Stimulation in CRT Patients with Quadripolar LV Leads:The Efface Q Study显示文摘 | Oswald H Asbach S Kbe J3 | 2015 | Pacing Clin Electrophysiol2015，38，8： | 1 |
| 10 | Merger negotiations and thetoehold puzzle显示文摘 | Betton S Eckbo BE Thorburn KS | 2009 | Journal of Financial Economics2009，91，： | 1 |
| 11 | A phase IIb dose- ranging study of the oral JAK inhibitor tofacitinib(CP-690, 550 ) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone显示文摘 | Kremer JM Cohen S Wilkinson BE | 2012 | Arthritis Rheum2012，64，4： | 1 |
| 12 | Satisfaction survey in gener- al hospital personnel involved in blood transfusion: implementation of the ISO 9001:2000 standard 显示文摘 | Chord-Auger S Tron BE Moll MC | 2004 | Transfus Clin Biol2004，11，4： | 1 |
| 13 | A phase ?b dose-ranging study of the oral JAK inhibitor tofacitinib(CP-690 550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone显示文摘 | Kremer JM Cohen S Wilkinson BE | 2012 | Arthritis Rheum2012，64，4： | 1 |
| 14 | Rapid identifica- tion, virulence analysis and resistance profiling of Staphylococcus aureus bygene segment-based DNA microarrays: application to blood culture post-processing 显示文摘 | Palka-Santini M Plitzfeld S Cleven BE | 2007 | J Microbiol Methods2007，68，3： | 1 |
| 15 | Turnover and nature of fecal bile acids in germ free and infected rats fed cholic acid 24-14; bile acids and steroids 41 显示文摘 | Gustafsson BE Bergstrom S Lindsted S | 1957 | Proc Soc Exp Biol Med1957，94，3： | 1 |
| 16 | Thmnfi)oelastometry: a contribution to perioperative free-flap management 显示文摘 | Wikner J Beck-Broichsitter BE Schlesinger S | 2015 | J Craniomaxillofac Surg2015，43，7： | 1 |
| 17 | Elevated levels of homocysteine increase IL-6 production in monocytic Mono Mac 6 cells 显示文摘 | van Aken BE Jansen J van Deventer S J | 2000 | Blood Coagul Fibrinolysis2000，11，2： | 1 |
| 18 | Combined effects of routine blood pressure lowering and intensive glucose control on macrovascular and microvascular outcomes in patients with type 2 diabetes: New results from the ADVANCE trial显示文摘 | Zoungas S de Galan BE Ninomiya T | 2009 | Diabetes Care2009，32，11： | 1 |
| 19 | Births: final data for 2001 显示文摘 | Martin JA Hamilton BE Ventura S J | 2002 | National Statistics Report2002，51，2： | 1 |
| 20 | Classification and surlical correction of gynecomastia显示文摘 | Simon BE Hoffman S Kahan S | 1973 | Plast Reconstr Surg1973，51，1： | 1 |
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