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25篇 您的检索式:作者名="Beling H"
    题名 作者 年代 出处 被引量
1Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension显示文摘AIM:To explore the role of heat shock protein-90 (HSP-90) for nitrergic vasorelaxation in the splanchnic circulation in rats with and without portal hypertension. METHODS: Neuronal nitric oxide synthase (nNOS) and HSP-90 were analyzed by immunofluorescence, western blotting and co-immunoprecipitation in the mesenteric vasculature and isolated nerves of portal-vein-ligated (PVL) rats and sham operated rats. In vitro perfused de-endothelialized mesenteric arterial vasculature was preconstricted with norepinephrine (EC80) and tested for nNOS-mediated vasorelaxation by periarterial nerve stimulation (PNS, 2-12 Hz, 45V) before and after incubation with geldanamycin (specific inhibitor of HSP-90 signalling, 3 μg/mL) or L-NAME (non-specific NOSblocker, 10-4 mol/L). RESULTS: nNOS and HSP-90 expression was significantly increased in mesenteric nerves from PVL as compared to sham rats. Moreover, nNOS and HSP-90 were visualized in mesenteric nerves by immunofluorescence and immunoprecipitation of nNOS co-immunoprecitated HSP-90 in sham and PVL rats. PNS induced a frequencydependent vasorelaxation which was more pronounced in PVL as compared to sham rats. L-NAME and geldanamycin markedly reduced nNOS-mediated vasorelaxation abrogating differences between the study groups. The effect of L-NAME and geldanamycin on nNOS-mediated vasorelaxation was significantly greater in PVL than in sham animals. However, no difference in magnitude of effect between L-NAME and geldanamycin was noted. CONCLUSION: HSP-90 acts as a signalling mediator of nNOS-dependent nerve mediated vascular responses in mesenteric arteries, and the increased nitrergic vasorelaxation observed in portal hypertension is mediated largely by HSP-90.Lukas Moleda Lars Jurzik Matthias Froh Erwin Gbele Claus Hellerbrand Rainer H Straub Jürgen Schlmerich Reiner Wiest 2010World Journal of Gastroenterology2010,16,15:4
2Critical comparison of emission spectroscopic determination of dissociation in hydrogen RF discharges显示文摘Gathen V S D(o)bele H F 1996Plasma Chem Plasma Proc1996,16,:1
3ADHD and comoribid disorders in relation to family environment and symptom severity 显示文摘Hurting T beling H Taanila A 2007Eur Child Adolesc Psychiatry2007,30,5:1
4Efficiency of Carbona-ceous Materials for Sorbing Polychlorinated Biphenyls FromAqueous Solution显示文摘BELES S B RIFAI H S RODRIGUES D F 2014Environmental Science & Technology2014,48,10:1
5Literacy through media:identity and discourse in the process of constructing a weh site显示文摘H e'ctor Del- Castillo A na Bele'n G arc'a- Varela Pilar Lacasa 2003International Journal of Educational Resea:h2003,,9:1
6Positronlifetime study of compensation defects in undoped semi-insulating InP显示文摘Beling C D Deng A H Shan Y Y etal 1998Phys Rev B1998,58,13:1
7United kingdom national paediatric bilateral cochlear implant audit:preliminary results显示文摘CULLINGTON H BELE D BRINTON J 2013Cochlear Implants Int2013,14,:1
8Design and fabrication of 60-Gb/s Inp-based monolithic photoreceiver OEICs and modules显示文摘Bach H G Beling S Mekonnen G G 2002IEEE Journal of Selected Topics in Quantum Electronics2002,8,6:1
9Positron- lifetime study of compensation defects in undoped semi-insulating InP 显示文摘Beling C D Deng A H Shah Y Y etal 1998Phys Rev B1998,58,13:1
10Experiments on robot-assisted navigated drilling and milling of bones for pedicle screw placement显示文摘Ortmaier T Weiss H Dbele S 2006Int J Med Robot2006,2,4:1
11Oxyconformity in the intertidal worm Sipunculus nudus: the nitochondrial background and energetic consequences 显示文摘Bucher T A bele D Portner H O 2001Comparative Biochemistry and Physioloy Part B2001,129,:1
12Microsatellite genetic map of the turbot (Scophthalmus maximus)显示文摘Carmen B Miguel H Bele'n G 2007Genetics2007,107,2:1
13Population aging and migrant workers: bottlenecks in tuberculosis control in rural China显示文摘Bele S Jiang W Lu H 2014PLoS One2014,9,2:1
14Experiences of returning to elite beach volleyball after shoulder injury 显示文摘Bele S Sstenberg A H Sjstrm R 2015J Exerc Reha- bil2015,11,4:1
15Design and fabrication of 60-Gb/s InP-based monolithic photoreceiver OEICs and modules显示文摘Bach H G Beling A Mekonnen G G 2002IEEE J Selected Topics in quantum electronics2002,8,6:1
16Semioonductor TiO2 Gas Sensor for Controlling Nitrocarburizing Proeeaaes显示文摘Klümper-Westkamp H Beling S Mehner A 2004Metal Science and Heat Treatment2004,46,7:1
17Positron-lifetime study of compensation defects in undopedsemi-insulating InP 显示文摘Beling C D Deng A H Shan Y Y 1998Phys Rev B1998,58,13:1
18Defects in ZnO nanorods prepared by a hydrothermal method 显示文摘TAM K H CHEUNG C K LEUNG Y H DJURISIC A B LING C C BELING C D FUNG S KWOK W M CHAN W K PHILLIPS D L DING L GE W K 2006Journal of Physics Chemical B2006,110,20:1
19Defects in ZnO Nanorods Prepared by a Hydrothermal Method显示文摘Tam K H Cheung C K Leung Y H Djurii6 A B Ling C D Beling C D Fung S Kwok W M Chart W K Philips D L Ding L Ge W K 2006The Journal of Physical Chemistry B2006,110,20:1
20High-power monolithieally integrated traveling wave photodiode array显示文摘BELING A CHEN H PAN H 2009IEEE Photonics Technology Letters2009,15,21:1
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