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| 1 | Percutaneous closure of secundum type atrial septal defects:More than 5-year follow-up显示文摘AIM: To investigate long-term efficacy of two different devices more than five years after percutaneous atrial septal defect(ASD) closure in adults.METHODS: All patients who underwent percutaneous closure of an ASD in the St. Antonius Hospital, Nieuwegein, The Netherlands, between February 1998 and December 2006 were included. Percutaneous closure took place under general anaesthesia and transesophageal echocardiographic moni toring. Transthoracic echocardiography(TTE) was performed 24 h post-procedure to visualize the device position and to look for residual shunting using color Doppler. All complications were registered. All patients were invited for an outpatient visit and contrast TTE more than 5-years after closure. Efficacy was based on the presence of a residual right-to-left shunt(RLS), graded as minimal, moderate or severe. The presence of a residual left-to-right shunt(LRS) was diagnosed using color Doppler, and was not graded. Descriptive statistics were used for patients' characteristics. Univariate analysis was used to identify predictors for residual shunting.RESULTS: In total, 104 patients(mean age 45.5 ± 17.1 years) underwent percutaneous ASD closure using an Amplatzer device(ASO) in 76 patients and a Cardioseal/Starflex device(CS/SF) in 28 patients. The mean follow-up was 6.4 ± 3.4 years. Device migration occurred in 4 patients of whom two cases occurred during the index hospitalization(1 ASO, 1 CS/SF). The other 2 cases of device migration occurred during the first 6 mo of follow-up(2 CS/SF). The recurrent thrombo-embolic event rate was similar in both groups: 0.4% per follow-up year. More than 12 mo post-ASD closure and latest follow-up, new-onset supraventricular tachyarrhythmia's occurred in 3.9% and 0% for the ASO and CS/SF group, respectively. The RLS rate at latest follow-up was 17.4%(minimal 10.9%, moderate 2.2%, severe 4.3%) and 45.5%(minimal 27.3%, moderate 18.2%, severe 0%) for the ASO- and CS/SF groups, respectively. There was no residual LRS in both groups.CONCLUSION: Percutaneous ASD closure has good long-term safety and efficacy profiles. The residual RLS rate seems to be high more than 5 years after closure, especially in the CS/SF. Residual LRS was not observed. | Roel JR Snijder Maarten J Suttorp Jurrien M Ten Berg Martijn C Post | 2015 | World Journal of Cardiology2015，7，3： | 6 |
| 2 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 3 | Pericytes synthesize renin显示文摘AIM: To investigate renin expression in pericytes during normal kidney development and after deletion of angiotensinogen, the precursor for all angiotensins.METHODS: We examined the distribution of renin expressing cells by immunoshistochemistry in the interstitial compartment of wild type(WT) and angiotensinogen deficient(AGT-/-) mice at different developmental stages from embryonic day 18(E18: WT, n = 4; AGT-/-, n = 5) and at day 1(P1: WT, n = 5; AGT-/-, n = 5), 5(P5: WT, n = 7; AGT-/-, n = 8), 10(P10: WT, n = 3; AGT-/-, n = 5), 21(P21: WT, n = 7; AGT-/-, n = 5), 45(P45: WT, n = 3; AGT-/-, n = 3), and 70(P70: WT, n = 2; AGT-/-, n = 2) of postnatal life. We quantified the number of pericytes positive for renin at all the developmental stages mentioned above and comparedthe results of AGT-/- mice to their WT counterparts.RESULTS: In WT mice, renal interstitial pericytes synthesize renin in early life supporting a lineage relationship with renin cells in the vasculature. The number of pericytes positive for renin per area of 0.32 mm2(density) in WT mice was maintained from fetal life till weaning age(E18 = 4.25 ± 0.63, P1 = 3.75 ± 0.48, P5 = 3.75 ± 0.48, P10 = 4 ± 0.71, P21 = 3.8 ± 0.58) and markedly decreased in adult life(P45 = 1.2 ± 0.37, P70 = 0.8 ± 0.20). On the other hand, in AGT-/- mice the density of pericytes expressing renin was not significantly different from WT mice at E18 and P1: E18 = 5.75 ± 0.50 vs 4.25 ± 0.63(P = 0.106), P1 = 9.25 ± 3.50 vs 3.75 ± 0.48(P = 0.175) but significantly increased from P5 till P70: P5 = 38.25 ± 5 vs 3.75 ± 0.48(P = 0.0004), P10 = 173 ± 7.50 vs 4 ± 0.70(P = 5.24567 × 10-7), P21 = 83 ± 6.70 vs 3.8 ± 0.58(P = 2.97358 × 10-6), P45 = 49 ± 3.50 vs 1.2 ± 0.37(P = 8.18274 x 10-7) and P70 = 17.8 ± 2.30 vs 0.8 ± 0.20(P = 3.51151 × 10-5). The AGT-/- mice showed a marked increase in the number of pericytes per field studied starting from P5, reaching its peak at P10, and then a gradually decreasing until P70. CONCLUSION: Interstitial pericytes synthesize renin during development and the number of renin-expressing pericytes increases in response to a homeostatic threat imposed early in life such as lack of angiotensinogen. | Alison C Berg Catalina Chernavvsky-Sequeira Jennifer Lindsey R Ariel Gomez Maria Luisa S Sequeira-Lopez | 2013 | World Journal of Nephrology2013，2，1： | 2 |
| 4 | Local dynamics in DNA by temperature-dependent stokes shifts of an intercalated dye 显示文摘 | Brauns E B Murphy C J Berg M A | 1998 | J Am Chem Soc1998，120，： | 1 |
| 5 | The variation of the Q angle with different positions of the foot显示文摘 | Olerud C Berg P | 1984 | Clin Orthop1984，191，： | 1 |
| 6 | Autophagosome-associated variant isoforms of cytosolic enzymes显示文摘 | Fengsrud M Raiborg C Berg TO Strmhaug PE Ueno T Erichsen ES Seglen PO | 2000 | Biochem J2000，352，3： | 1 |
| 7 | Growth parameters and meat quality of finishing hogs supplemented with creatine monohydrate and a high dlycemic carbohydrate for the last 30 days of production显示文摘 | Stahl C A Berg E P | 2003 | Meat Sci2003，64，： | 1 |
| 8 | Leading edge vortices in insect flight显示文摘 | Ellington C P van den Berg C Willmott A P | 1996 | Nature1996，347，： | 1 |
| 9 | Accuracy of abnormal karyotypes after the analysis of both short and long term culture of chofionic villi显示文摘 | van den Berg C Van Op staiD Brandenberg H | 2000 | Prenat Diagn2000，20，12： | 1 |
| 10 | NMR relaxometryand differential scanning calorimetry during meat cooking显示文摘 | BERTRAMH C WU ZHIYUN VAN DEN BERG F | 2006 | Meat Science2006，，74： | 1 |
| 11 | Motivation and satisfaction among polyclinic volunteers at the 2002 Winter Olympic and Paralympie Games 显示文摘 | Recscr J C Berg R L Rhea D | 2005 | British Journal of Sports Medicine2005，39，4： | 1 |
| 12 | Leading-edge vortices in insect flight显示文摘 | Ellington C P van den Berg C | 1996 | Nature1996，384，： | 1 |
| 13 | Identification, purification, and characterization of a thiol-activated hemolysin(suilysin) of Streptococcus suis 显示文摘 | JACOBS A A C LOEFFEN P L W BERG A J G | 1994 | Infect Immun1994，62，5： | 1 |
| 14 | Fast-growing, shallow-water ferromanganese nodules from the western Baltic Sea: origin and modes of trace element incorporation显示文摘 | HLAWATSCH S NEUMANN T Van den BERG C M G | 2002 | Marine Geology2002，182，： | 1 |
| 15 | The determination of purines in fresh and sea water by cathodic stripping vohammetry after complexation with copper( Ⅰ )显示文摘 | HOUSEHAM B C VAN DEN BERG C M G PILEY J P | 1987 | Anal Chim Acta1987，200，： | 1 |
| 16 | A comparison of SATORI and HB effectivemedium conductivity models 显示文摘 | Berg C R | 1998 | The Log Analyst1998，39，5： | 1 |
| 17 | Modeling directivity of heterogeneous earthquake rupture 显示文摘 | Bernard P Herrero A Berge C | 1996 | Bulletin of the Seismological Society of America1996，86，： | 1 |
| 18 | Amplification of an es terase gene is responsible for insecticide resistance in a California Culex mosquito显示文摘 | Mouches C Pasteur N Berge JB | 1986 | Science1986，233，： | 1 |
| 19 | Microencapsulation of emulsified oil droplets by in-situ vinyl polymerization显示文摘 | Berg J Sundberg D C Kronberg B J | | 0，，： | 1 |
| 20 | Oil-in-water emulsions for encapsulated delivery of reactive iron particles 显示文摘 | Berge N D Ramsburg C A | 2009 | Environmental Science & Technology2009，43，13： | 1 |
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