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| 1 | Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain显示文摘AIM: To systematically characterize specific pain patterns in the most frequent pancreatic diseases.METHODS: Pain in patients with chronic pancreatitis(n = 314), pancreatic cancer(n = 469), and other pancreatic tumors(n = 249) including mucinous(n = 20) and serous cystadenoma(n = 31), invasive(n = 37) and non-invasive intraductal papillary mucinous neoplasia(IPMN; n = 48), low stage(n = 18) and high stage neuroendocrine neoplasia(n = 44), and ampullary cancer(n = 51) was registered and correlated with clinicopathological data. Survival times were estimated by the Kaplan-Meier method. Patients alive at the follow-up time were censored. Survival curves were compared statistically using the log-rank test.RESULTS: Forty-nine point one percent of pancreatic cancer patients revealed no pain, whereas in chronic pancreatitis only 18.3% were pain free. In contrary, moderate/severe pain was registered in 15.1% in pancreatic cancer patients that was increased in chronic pancreatitis with up to 34.2%. Serous cystadenoma was asymptomatic in most cases(58.1%), whereas 78.9% of all mucinous cystadenoma patients suffered pain. In neuroendocrine neoplasia pain was not a key clinical symptom since 64% of low stage neuroendocrine neoplasia and 59% of high stage neuroendocrine neoplasia patients were pain free. Cancer localization in the pancreatic body and patients with malignant pancreatic neoplasms were associated with more severe pain. Tumor grading and stage did not show any impact on pain. Only in pancreatic cancer, pain was directly associated with impaired survival.CONCLUSION: Pancreatic pain depicts different patterns of abdominal pain sensation according to the respective pancreatic disorder and does not allow a unification of the term pancreatic pain. | Jan G D'Haese Mark Hartel Ihsan Ekin Demir Ulf Hinz Frank Bergmann Markus W Büchler Helmut Friess Güralp O Ceyhan | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 2 | Clinical evaluation of the BDProbe Tec ET system for rapid detection of My- cobacterium tuberculosis 显示文摘 | Bergmann JS Keating W E Woods GL | 2000 | J Clin Microbiol2000，38，2： | 1 |
| 3 | Downregulation of STAT3 signaling induces apoptosis but also promotes anti-apoptotic gene expression in human pancreatic cancer cell lines显示文摘 | Glienke W Hausmann E Bergmann L | 2011 | Tumour Biol2011，32，3： | 1 |
| 4 | Role of beta-catenin in adult cardiac remodeling显示文摘 | ZELLARAYAN L GEHRKE C BERGMANN M W | 2007 | Cell Cycle2007，6，17： | 1 |
| 5 | Fluorescence lifetime imaging by time-correlated single photon counting 显示文摘 | Becker W Bergmann A Hink M A | 2004 | Micr Res Techn2004，63，： | 1 |
| 6 | Isolation and characterization of an endopolygalacturonase from Cochliobolus sativus and a cytological study of fungal penetration of barley显示文摘 | CLAY R P BERGMANN C W FULLER M S | 1997 | Phytopathology1997，87，11： | 1 |
| 7 | Tibio-femoral loading during human gait and stair climbing显示文摘 | Taylor W Heller M Bergmann G | 2004 | J Orthop Res2004，22，3： | 1 |
| 8 | An Arabic optical character recognition system using recognition-based segmentation显示文摘 | Cheung A Bennamoun M Bergmann N W | 2001 | Pattern Recognition2001，34，： | 1 |
| 9 | Coherent Population Transfer Among Quantum States of Atoms and Molecules 显示文摘 | BERGMANN K THEUER H SHORE B W | 1998 | Rev Mod Phys1998，70，3： | 1 |
| 10 | Laser and eceltron - beam mehed amorphous layers显示文摘 | Bergmann H W Mordike B L | 1981 | Journal of Materials Science1981，16，： | 1 |
| 11 | Stomatal development and pattern controlled by a MAPKK kinase 显示文摘 | Bergmann D C Lukowitz W Somerville C R | 2004 | Science2004，304，5676： | 1 |
| 12 | Cerbral perfusion (HMPAO SPECT) in patients with depression and cognitive impairment versus those with mild cognitive impairment and dementia of Alzheimer's type:semiquantitative and automated evalution显示文摘 | Staffen W Bergmann J Schonauer U | 2009 | Eur J Nucl Med Mol Imaging2009，36，5： | 1 |
| 13 | Pinch plasma radiation sources for the extreme ultraviolet 显示文摘 | NEFF W BERGMANN K ROSIER O | 2001 | Contrib Plasma Phys2001，41，6： | 1 |
| 14 | Novel industrial wireless sensor networks for machine condition monitoring and fault diagnosis显示文摘 | HOU L BERGMANN N W | 2012 | IEEE Transactions on Instrumentation & Measurement2012，61，10： | 1 |
| 15 | In cardiomyocyte hypoxia,insulin-like growth factor-I-induced antiapoptotic signaling requires pbosphatidylinositol-3-OHkinase-dependent and mitogen-activated protein kinasedependent activation of the transcription factor cAMP response element-binding protein显示文摘 | Mehrhof F B Muller F U Bergmann M W | 2001 | Circulation2001，104，17： | 1 |
| 16 | and Grone I'Ll (2010) Reduction of circulating soluble Fit- 1 alleviates pre- eclampsia - like symptoms in a mouse model 显示文摘 | Bergmann A Ahmad S Cudmore M Gruber AD Wittschen P Lindenmaier W Christofori G Gross V Gonzalves A | 2010 | J Cell Mol Med2010，，： | 1 |
| 17 | Discovered on gastrointes-tinal stromal tumor 1 ( DOG1) is expressed in pancreatic centroacinarcells and in solid-pseudopapifiary neoplasms-novel evidence for a his-togenetic relationship显示文摘 | Bergmann F Andrulis M Hartwig W | 2011 | Hum Pathol2011，42，6： | 1 |
| 18 | Novel Industrial Wireless Sensor Networks for Machine Condition Monitoring and Fault Diagno sis显示文摘 | Liqun H Bergmann N W | 2012 | Instrumentation and Measurement IEEE Transactions on2012，10，61： | 1 |
| 19 | Decreased protamine-1 transcript levels in testes from infertile men显示文摘 | Steger K Fink L Failing K Bohle R M Kliesch S Weidner W Bergmann M | | 0，，06： | 1 |
| 20 | Nutrient recovery from swine lagoon water by Spirodela punctata显示文摘 | Cheng J Y Bergmann B A Classen J J Stomp A M Howard J W | 2002 | Bioresource Technology2002，81，： | 1 |
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