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210篇 您的检索式:作者名="Bernabeu"
    题名 作者 年代 出处 被引量
1A role for the Tgf-β/Bmp co-receptor Endoglin in the molecular oscillator that regulates the hair follicle cycle显示文摘The hair follicle is a biological oscillator that alternates growth,regression,and rest phases driven by the sequential activation of the proliferation differentiation programs of resident stem cell populations.The activation of hair follicle stem cell niches and subsequent entry into the growing phase is mainly regulated by Wnt/β-catenin signalling,while regression and resting phases are mainly regulated by Tgf-β/Bmp/Smad activity.A major question still unresolved is the nature of the molecular switch that dictates the coordinated transition between both signalling pathways.Here we have focused on the role of Endoglin(Eng),a key co-receptor for members of the Tgf-β/Bmp family of growth factors.Using an Eng haploinsufficient mouse model,we report that Eng is required to maintain a correct follicle cycling pattern and for an adequate stimulation of hair follicle stem cell niches.We further report thatβ-catenin binds to the Eng promoter depending on Bmp signalling.Moreover,we show thatβ-catenin interacts with Smad4 in a Bmp/Eng-dependent context and both proteins act synergistically to activate Eng promoter transcription.These observations point to the existence of a growth/rest switching mechanism in the hair follicle that is based on an Eng-dependent feedback cross-talk between Wnt/β-catenin and Bmp/Smad signals.Maria I.Calvo-Sanchez Sandra Fernandez-Martos Elisa Carrasco Gema Moreno-Bueno Carmelo Bernabeu Miguel Quintanilla Jesus Espada 2019Journal of Molecular Cell Biology2019,11,1:7
2CD105 and angiogenesis显示文摘Kumar p wang JK Bernabeu C 1996J Pathology1996,178,4:1
3Characterization of aberrated laser beams 显示文摘ALDA J ALONSO J BERNABEU E 1997J O S A1997,14,10:1
4Angiogenesis in breast cancer:the role of transforming growth factor beta and CD105 显示文摘Li C Guo B Bernabeu C et aI 2001Microsc Res Tech2001,52,4:1
5Hypo-pituitarism following traumatic brain injury:determining fac-tors for diagnosis显示文摘Femandez-Rodriguez E Bernabeu I Castro AI 2011Front Endocrinol(Lausanne)2011,2,:1
6Optical performance of monofocal and multifocal intraocular lenses in the human eye显示文摘Ortiz D Alio JL Bernabeu G 2008J Cataract Refract Surg2008,34,5:1
7Angiogenesis in breast cancer:the role of transforminggrowth factor beta and CD105显示文摘Li C Guo B Bernabeu C 2001Microse Res Tech2001,52,:1
8Characterization of aberrated laserbeams显示文摘ALDA J ALONSO J BERNABEU E 1997J Opt Soc Am A1997,14,10:1
9TGF -显示文摘Santibanez JF Quintanilla M Bernabeu C 2011Clin Sci ( Lond)2011,121,6:1
10TGF-β/TGF-13 receptor system and its role in physiological and pathological condition显示文摘Santibanez JF Quintanilla M Bernabeu C 2011Clin Sci (Lond)2011,121,6:1
11The transferrin receptor and the targeted delivery of therapeutic agents against cancer显示文摘Daniels TR Bernabeu E Rodríguez JA 2012Biochim Biophys Acta2012,1820,3:1
12Muhicopy blaOXA-58 gene as a source of high-level resistance to OXA-58 carbapenemsin Acinetobacter baumannii 显示文摘Bertini A Poirel L Bernabeu S 2007Antimicrob Agents Chemother2007,51,7:1
13TGF-beta/TGF-be- ta receptor system and its role in physiological and pathological conditions显示文摘Santibanez JF Quintanilla M Bernabeu G 2011Clin Sci (Lond)2011,121,6:1
14Neurogenesis following brain ischemia显示文摘Sharp FR Liu J Bernabeu R 2002Brain Res Dev Brain Res2002,134,12:1
15Premature rupture of membranes before 34 weeks managed expectantly: maternal and perinatal outcomes in singletons 显示文摘Goya M Bernabeu A Garcia N 2013J Matern Fetal Neonatal Med2013,26,3:1
16TGF-β/TGF-βreceptor system and its role in physiological and pathological conditions显示文摘Santibaez JF Quintanilla M Bernabeu C 2011Clin Sci(Lond)2011,121,6:1
17Shift and broadening of hyperfine components of the first doublet of cesium perturbed by foreign gases显示文摘BERNABEU E ALVARE J M 1980Pays Bev A1980,22,:1
18Premature rupture of membranes before 34 weeks managed expectantly:maternal and perinatal outcomes in singletons显示文摘Goya M Bernabeu A Garcia N 2013J Matern Fetal Neonatal Med2013,26,3:1
19Nicotine-conditioned place preference induced CREB phosphorylation and Fos expression in the adult rat brain显示文摘Pascual MM Pastor V Bernabeu RO 2009Psychopharmacology(Berlin)2009,207,:1
20TGF-β/TGF-β re ceptor system and its role in physiological and pathological con- ditions 显示文摘Santihanez JF Quintanilla M Bernabeu C 2011Clin Sci(Lond)2011,121,6:1
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