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| 1 | Endoscopic ultrasound-guided vs endoscopic retrograde cholangiopancreatography biliary drainage for obstructed distal malignant biliary strictures: A systematic review and meta-analysis显示文摘BACKGROUND For palliation of malignant biliary obstruction(MBO), the gold-standard method of biliary drainage is endoscopic retrograde cholangiopancreatography(ERCP)with the placement of metallic stents. Endoscopic ultrasound(EUS)-guided drainage is an alternative that is typically reserved for cases of ERCP failure.Recently, however, there have been robust randomized clinical trials(RCTs)comparing EUS-guided drainage and ERCP as primary approaches to MBO.AIM To compare EUS guidance and ERCP in terms of their effectiveness and safety in palliative biliary drainage for MBO.METHODS This was a systematic review and meta-analysis, in which we searched the MEDLINE, Excerpta Medica, and Cochrane Central Register of Controlled Trials databases. Only RCTs comparing EUS and ERCP for primary drainage of MBO were eligible. All of the studies selected provided data regarding the rates of technical and clinical success, as well as the duration of the procedure, adverse events, and stent patency. We assessed the risk of biases using the Jadad score and the quality of evidence using the Grading of Recommendations Assessment,Development and Evaluation criteria.RESULTS The database searches yielded 5920 records, from which we selected 3 RCTs involving a total of 222 patients(112 submitted to EUS and 110 submitted to ERCP). In the EUS and ERCP groups, the rate of technical success was 91.96%n and 91.81%, respectively, with a risk difference(RD) of 0.00%(95%CI:-0.07, 0.07;P = 0.97; I^2 = 0%). The clinical success was 84.81% and 85.53% in the EUS and ERCP groups, respectively, with an RD of-0.01%(95%CI:-0.12, 0.10; P = 0.90; I^2 =0%). The mean difference(MD) for the duration of the procedure was-0.12%(95%CI:-8.20, 7.97; P = 0.98; I^2 = 84%). In the EUS and ERCP groups, there were14 and 25 adverse events, respectively, with an RD of-0.06%(95%CI:-0.23, 0.12; P= 0.54; I^2 = 77%). The MD for stent patency was 9.32%(95%CI:-4.53, 23.18; P =0.19; I^2 = 44%). The stent dysfunction rate was significantly lower in the EUS t group(MD =-0.22%; 95 CI:-0.35,-0.08; P = 0.001; I^2 = 0%).CONCLUSION EUS represents an interesting alternative to ERCP for MBO drainage,demonstrating lower stent dysfunction rates compared with ERCP. Technical and clinical success, duration, adverse events and patency rates were similar. | Fernanda P Logiudice Wanderlei M Bernardo Facundo Galetti Vitor M Sagae Carolina O Matsubayashi Antonio C Madruga Neto Vitor O Brunaldi Diogo T H de Moura Tomazo Franzini Spencer Cheng Sergio E Matuguma Eduardo G H de Moura | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，4： | 6 |
| 2 | Pain treatment with high-dose, controlled-release oxycodone: an Italian perspective显示文摘 | Ferrarese F Becchimanzi G Bernardo M | 2008 | Ther Clin Risk Manag2008，4，4： | 1 |
| 3 | Molecular typing of Italian sweet chestnut cuhivars by random amplified polymorphic DNA analysis 显示文摘 | GALDERISI U CIPOLLARO M DI BERNARDO G DE MASI L | 1998 | Horticultural Science and Biotechnology1998，73，2： | 1 |
| 4 | High-dose carboplatin superselective intraarterial chemotherapy in advanced head and neck cancer 显示文摘 | Benazzo M Bernardo G Corbella F | 1996 | Acta Otorhinolaryngol Ital1996，16，1： | 1 |
| 5 | Dynamic contrast-en- hanced MRI of prostate cancer at 3 T: a study of pharmacokinetic parameters 显示文摘 | Ocak I Bernardo M Metzger G | 2007 | AJR2007，189，4： | 1 |
| 6 | Two-parameter discon-tinuity induced bifurcation curves in a ZAD-strategy-controlled DC-DC Buck converter 显示文摘 | ANGULO F OLIVAR G BERNARDO M | 2008 | IEEE Transactions on Circuits and SystemsI: Regular Papers2008，55，8： | 1 |
| 7 | Characterization and supercritical carbon dioxide extraction ofwalnut oil显示文摘 | Oliveira R Rodrigues M F Bernardo - Gil M G | 2002 | J Am Oil Chem Soc2002，79，3： | 1 |
| 8 | Prognostic value of podoplanin expression in intratumoral stro- ma and neoplastic cells of uterine cervical carcinomas 显示文摘 | Filomena M Carvalho Fabricia L Zaganelli Bernardo G L AImeida | 2010 | Clinics2010，65，12： | 1 |
| 9 | Bifurcations in non-smooth dynamical systems显示文摘 | di Bernardo M Budd C Champneys A R Kowalczyk P Nordmark A B Olivvar G Piiroinen P T | 2008 | SIAM Review2008，50，4： | 1 |
| 10 | First-linechemo therapy with vinorelbine, gemcitabine, and carboplatin in the treatmentof brain metastas esfrom non-small·-celllung can cer: a phase IIstudy显示文摘 | Bernardo G Cuzzoni Q Strada M R | 2002 | CancerInvest2002，20，3： | 1 |
| 11 | Molecular typing of Italian sweet chestnut cultivars by random amplified polymorphic DNA analysis显示文摘 | Galderis U Cipollaro M Bernardo G | 1998 | Hort Sci Biotech1998，73，2： | 1 |
| 12 | Contraction theory and masterstability function : linking two approaches to study synchro-nization of complex networks显示文摘 | Russo G di Bernardo M | 2009 | IEEE Transactions on Cir-cuits and Systems II:Express Briefs2009，56，2： | 1 |
| 13 | Dynamic contrast- enhanced MRI of prostate cancer at 3 T: a study of pharmacokinetic parameters 显示文摘 | Ocak I Bernardo M Metzger G | 2007 | AIR Am J Roemgenol2007，189，： | 1 |
| 14 | Dynamic contrast enhanced MRI of prostate cancer at 3T:a study of pharmacokinetic parameters显示文摘 | Ocak I Bernardo M Metzger G | 2007 | AJR2007，189，4： | 1 |
| 15 | A Review of Antarctic Surface Snow Isotopic Composition: Observations, Atmospheric Circulation, and Isotopic Modeling*显示文摘 | Masson-Delmotte V Hou S Ekaykin A Jouzel J Aristarain A Bernardo R T Bromwich D Cattani O Delmotte M Falourd S Frezzotti M Gallée H Genoni L Isaksson E Landais A Helsen M M Hoffmann G Lopez J Morgan V Motoyama H Noone D Oerter H Peti | 2008 | Journal of Climate2008，，13： | 1 |
| 16 | Incidence and outcome of De Novo malignancies after liver transplantation显示文摘 | M.L Galve V Cuervas-Mons J Figueras I Herrero M Mata G Clemente M Prieto C Margarit A Bernardos F Casafont | 1999 | Transplantation Proceedings1999，，1： | 1 |
| 17 | Comparision of methods for extraction of tobacco alkaloids显示文摘 | JONES N M BERNARDO GIL M G LOURENCO M G | 2001 | J AOAC2001，84，2： | 1 |
| 18 | Analysis andperformance of the control systems of the NASA 70-meterantennas 显示文摘 | Gawronski W Ahlstrom H G Bernardo A M | 2004 | ISA Transactions2004，43，4： | 1 |
| 19 | Identification of hazelnut(Corylus avellana)cultivars by RAPD analysis显示文摘 | GAIDERISI U GIPOLLARO M BERNARDO G D I | 1999 | Plant Gell Reports1999，17，78： | 1 |
| 20 | Pain treatment with high-dose,controlled-release oxycodone:an Italian perspective显示文摘 | Ferrarese F Becchimanzi G Bernardo M | 2008 | Ther Clin Risk Manag2008，，4： | 1 |
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