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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Bile leakage after loop closure vs clip closure of the cystic duct during laparoscopic cholecystectomy:A retrospective analysis of a prospective cohort显示文摘BACKGROUND Laparoscopic cholecystectomy(LC)is one of the most frequently performed surgical procedures.Cystic stump leakage is an underestimated,potentially life threatening complication that occurs in 1%-6%of the patients.With a secure cystic duct occlusion technique during LC,bile leakage becomes a preventable complication.AIM To investigate the effect of polydioxanone(PDS)loop closure of the cystic duct on bile leakage rate in LC patients.METHODS In this retrospective analysis of a prospective cohort,the effect of PDS loop closure of the cystic duct on bile leakage complication was compared to patients with conventional clip closure.Logistic regression analysis was used to develop a risk score to identify bile leakage risk.Leakage rate was assessed for categories of patients with increasing levels of bile leakage risk.RESULTS Of the 4359 patients who underwent LC,136(3%)underwent cystic duct closure by a PDS loop.Preoperatively,loop closure patients had significantly more complicated biliary disease compared to the clipped closure patients.In the loop closure cohort,zero(0%)bile leakage occurred compared to 59 of 4223(1.4%)clip closure patients.For patients at increased bile leakage risk(risk score≥1)rates were 1.6%and up to 13%(4/30)for clip closure patients with a risk score≥4.This risk increase paralleled a stepwise increase of actual bile leakage complication for clip closure patients,which was not observed for loop closure patients.CONCLUSION Cystic duct closure with a PDS loop during LC may reduce bile leakage in patients at increased risk for bile leakage. | Sandra C Donkervoort Lea M Dijksman Aafke H van Dijk Emile A Clous Marja A Boermeester Bert van Ramshorst Djamila Boerma | 2020 | World Journal of Gastrointestinal Surgery2020，12，1： | 4 |
| 3 | Computational models for sandwich panels and shells显示文摘 | Noor A K Burton W S Bert C W | 1996 | Applied Mechanics Reviews1996，4，3： | 1 |
| 4 | Material Damping: An Introductory Review of Mathematical Models, Measures and Exprimental Techniques显示文摘 | Bert C W | 1973 | Journal of Sound and Vibration1973，29，： | 1 |
| 5 | Raman spectroscopy employed for the determination of the intermediate phase in polyethylene显示文摘 | CHRISTOPHER C N ROBERT J M BERT J K et al | 1995 | Macromolecules1995，28，8： | 1 |
| 6 | The differential quadrature method in computational mechanics: A review显示文摘 | Bert C W Malik M | 1996 | Appl Mech Rev1996，，： | 1 |
| 7 | Differential quadrature analysis of deflection, buckling and vibration of beams and rectangular plates 显示文摘 | Wang X Bert C W Stirz A G | 1993 | Computers & Structures1993，48，3： | 1 |
| 8 | Vibration of thick rectangular plates of bimodulous composite material显示文摘 | Bert C W Reddy J N Chao W C | 1981 | Journal of Applied Mechanics1981，48，2： | 1 |
| 9 | Evaluating laboratory perform-ance on quality indicators with the six sigma scale 显示文摘 | NevalainenD Berte L Kraft C | 2000 | Arch PatholLab Med2000，124，4： | 1 |
| 10 | SIMULSERRE:an educational software simulating the greenhouse-crop systems显示文摘 | Gary C Tchamitchian M Bert in N | 1998 | Acta Horticulturae1998，45，6： | 1 |
| 11 | Implementting multiple boundary conditions in the DQ solution of hingher-order PDE's: application to free vibration of plates显示文摘 | Malik M Bert C W | 1996 | International Journal for Numerical Methods in Engineering1996，39，7： | 1 |
| 12 | Application ofseismic attributes at the 3D seismic interpretation显示文摘 | Bibiana Kytková Patrik Hutman Róbert Prochác | 2009 | Acta Geo-logica Slovaca2009，1，2： | 1 |
| 13 | Identification of PSE and OXA β-lactamase genes in Pseudomonas aeruginosa using PCR-restriction fragment length polymorphism显示文摘 | Bert F Branger C Lambert-Zechovsky N | 2002 | J Antimicrob Chemother2002，50，1： | 1 |
| 14 | Physical and bioticdrivers of plant distribution across estuarine salinity gradients显示文摘 | Crain C M Silliman B R Bertness S L | 2004 | Ecology2004，85，： | 1 |
| 15 | Tricuspid valve replacement: an analysis of 25 years of experience at a single center显示文摘 | Michel Carrier Yves Hébert Michel Pellerin Denis Bouchard Louis P Perrault Raymond Cartier Arsène Basmajian Pierre Pagé Nancy C Poirier | 2003 | The Annals of Thoracic Surgery2003，，1： | 1 |
| 16 | Differential quadrature solutions for steady-slate incompressible and compressible lubrication prob-lems显示文摘 | Malik M Bert C W | 1994 | Journal of Tribology1994，116，： | 1 |
| 17 | Improved technique for estimating buckling loads显示文摘 | BERT C W | 1984 | J Eng Mech1984，110，： | 1 |
| 18 | Differential Quadrature Method in Computational Mechanics : A Review 显示文摘 | Bert C W Malik M | 1996 | Applied Mechanics Reviews1996，49，： | 1 |
| 19 | Evaluating laboratoryperformance on quality indicators with the six scale 显示文摘 | Nevalainen D Berte L Kraft C | 2000 | Arch Pathol Lab Med2000，124，4： | 1 |
| 20 | Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL 10 expression显示文摘 | Chauveau C Remy S Royer P J Hill M Tanguy Royer S Hu- bert F X | 2005 | Blood2005，106，： | 1 |
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